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  • 1
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    Probing supersymmetry using event shape variables at the 8 TeV LHC (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-10-11
    Description: Author(s): Rajdeep M. Chatterjee, Monoranjan Guchait, and Dipan Sengupta We have revisited the prospects of supersymmetry searches at the LHC with 7 TeV energy along with the prediction of the discovery potential at 8 TeV energy assuming an integrated luminosity 5  fb -1 and 20  fb -1 with minimal supergravity/minimal supersymmetric standard model as a model framework. We ... [Phys. Rev. D 86, 075014] Published Wed Oct 10, 2012
    Keywords: Beyond the standard model
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    How constrained is the constrained MSSM? (2012)
    American Physical Society (APS)
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    Publication Date: 2012-09-11
    Description: Author(s): Diptimoy Ghosh, Monoranjan Guchait, Sreerup Raychaudhuri, and Dipan Sengupta We study the allowed parameter space of the constrained minimal supersymmetric Standard Model (cMSSM) in the light of direct searches, constraints from B -physics (including the recent measurement of the branching ratio for B s → μ + μ - ) and the dark matter relic density. For low or moderate values of tan... [Phys. Rev. D 86, 055007] Published Mon Sep 10, 2012
    Keywords: Beyond the standard model
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 3
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    Probing a mixed neutralino dark matter model at the 7 TeV LHC (2012)
    American Physical Society (APS)
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    Publication Date: 2012-02-23
    Description: Author(s): Monoranjan Guchait, D. P. Roy, and Dipan Sengupta We have analyzed the prospect of probing a nonuniversal gaugino mass model of mixed bino-Higgsino dark matter at the current 7 TeV run of LHC. It provides cosmologically compatible dark matter relic density over two broad bands of parameters, corresponding to m g ˜ 〈 m q ˜ and m g ˜ ∼ m q ˜ . The supersymmetr... [Phys. Rev. D 85, 035024] Published Wed Feb 22, 2012
    Keywords: Beyond the standard model
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    Event-shape selection cuts for supersymmetry searches at the LHC with 7 TeV energy (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-09-14
    Description: Author(s): Monoranjan Guchait and Dipan Sengupta We investigate the prospects of supersymmetry searches at the LHC with 7 TeV energy. A new set of selection cuts is proposed based on event shapes to control backgrounds. Our preliminary studies show that it is possible to minimize backgrounds to a significantly low level and a conservative estimate... [Phys. Rev. D 84, 055010] Published Tue Sep 13, 2011
    Keywords: Beyond the standard model
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 5
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    Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-12
    Description: Mouse primordial germ cells (PGCs) undergo sequential epigenetic changes and genome-wide DNA demethylation to reset the epigenome for totipotency. Here, we demonstrate that erasure of CpG methylation (5mC) in PGCs occurs via conversion to 5-hydroxymethylcytosine (5hmC), driven by high levels of TET1 and TET2. Global conversion to 5hmC initiates asynchronously among PGCs at embryonic day (E) 9.5 to E10.5 and accounts for the unique process of imprint erasure. Mechanistically, 5hmC enrichment is followed by its protracted decline thereafter at a rate consistent with replication-coupled dilution. The conversion to 5hmC is an important component of parallel redundant systems that drive comprehensive reprogramming in PGCs. Nonetheless, we identify rare regulatory elements that escape systematic DNA demethylation in PGCs, providing a potential mechanistic basis for transgenerational epigenetic inheritance.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847602/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847602/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hackett, Jamie A -- Sengupta, Roopsha -- Zylicz, Jan J -- Murakami, Kazuhiro -- Lee, Caroline -- Down, Thomas A -- Surani, M Azim -- 079249/Wellcome Trust/United Kingdom -- 083089/Wellcome Trust/United Kingdom -- 083563/Wellcome Trust/United Kingdom -- 092096/Wellcome Trust/United Kingdom -- RG44593/Wellcome Trust/United Kingdom -- RG49135/Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2013 Jan 25;339(6118):448-52. doi: 10.1126/science.1229277. Epub 2012 Dec 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23223451" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine/metabolism ; Animals ; CpG Islands ; Cytosine/*analogs & derivatives/metabolism ; *DNA Methylation ; DNA-Binding Proteins/genetics/metabolism ; Embryo, Mammalian/*metabolism ; Embryonic Development ; *Epigenesis, Genetic ; Female ; *Genomic Imprinting ; Germ Cells/*metabolism ; Germ Layers/cytology ; Male ; Mice ; Promoter Regions, Genetic ; Proto-Oncogene Proteins/genetics/metabolism ; RNA-Binding Proteins/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake (2012)
    Nature Publishing Group (NPG)
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    Publication Date: 2012-06-23
    Description: How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to calorie restriction. Calorie restriction acts by reducing mechanistic target of rapamycin complex 1 (mTORC1) signalling in Paneth cells, and the ISC-enhancing effects of calorie restriction can be mimicked by rapamycin. Calorie intake regulates mTORC1 in Paneth cells, but not ISCs, and forced activation of mTORC1 in Paneth cells during calorie restriction abolishes the ISC-augmenting effects of the niche. Finally, increased expression of bone stromal antigen 1 (Bst1) in Paneth cells-an ectoenzyme that produces the paracrine factor cyclic ADP ribose-mediates the effects of calorie restriction and rapamycin on ISC function. Our findings establish that mTORC1 non-cell-autonomously regulates stem-cell self-renewal, and highlight a significant role of the mammalian intestinal niche in coupling stem-cell function to organismal physiology.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387287/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387287/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yilmaz, Omer H -- Katajisto, Pekka -- Lamming, Dudley W -- Gultekin, Yetis -- Bauer-Rowe, Khristian E -- Sengupta, Shomit -- Birsoy, Kivanc -- Dursun, Abdulmetin -- Yilmaz, V Onur -- Selig, Martin -- Nielsen, G Petur -- Mino-Kenudson, Mari -- Zukerberg, Lawrence R -- Bhan, Atul K -- Deshpande, Vikram -- Sabatini, David M -- 1F32AG032833-01A1/AG/NIA NIH HHS/ -- CA103866/CA/NCI NIH HHS/ -- CA129105/CA/NCI NIH HHS/ -- F32 AG032833/AG/NIA NIH HHS/ -- P30 AG038072/AG/NIA NIH HHS/ -- P30 DK043351/DK/NIDDK NIH HHS/ -- R01 CA103866/CA/NCI NIH HHS/ -- R01 CA129105/CA/NCI NIH HHS/ -- T32CA09216/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2012 Jun 28;486(7404):490-5. doi: 10.1038/nature11163.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22722868" target="_blank"〉PubMed〈/a〉
    Keywords: ADP-ribosyl Cyclase/metabolism ; Animals ; Antigens, CD/metabolism ; Caloric Restriction ; Cell Count ; Cell Division/drug effects ; Cyclic ADP-Ribose/metabolism ; Energy Intake/*physiology ; Female ; GPI-Linked Proteins/agonists/metabolism ; Intestines/*cytology ; Longevity/physiology ; Male ; Mice ; Multiprotein Complexes ; Paneth Cells/*cytology/drug effects/*metabolism ; Paracrine Communication ; Proteins/antagonists & inhibitors/*metabolism ; Regeneration/drug effects ; Signal Transduction ; Sirolimus/pharmacology ; Stem Cell Niche/drug effects/*physiology ; Stem Cells/*cytology/drug effects/*metabolism ; TOR Serine-Threonine Kinases
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 7
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    The Development of a Long-Term, Continually Updated Global Solar Resource at 10 km Resolution: Preliminary Results From Test Processing and Continuing Plans (2014)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: Background: Considering the likelihood of global climatic weather pattern changes and the global competition for energy resources, there is an increasing need to provide improved and continuously updated global Earth surface solar resource information. Toward this end, a project was funded under the NASA Applied Science program involving the National Aeronautics and Space Administration (NASA) Langley Research Center (LaRC), National Renewable Energy Laboratory (NREL), the State University of New York/Albany (SUNY) and the NOAA National Climatic Data Center (NCDC) to provide NREL with a global long-term advanced global solar mapping production system for improved depiction of historical solar resources and variability and to provide a mechanism for continual updates of solar resource information. This new production system is made possible by the efforts of NOAA and NASA to completely reprocess the International Satellite Cloud Climatology Project (ISCCP) data set that provides satellite visible and infrared radiances together with retrieved cloud and surface properties on a 3-hourly basis beginning from July 1983. The old version of the ISCCP data provided this information for all the world TMs available geosynchronous satellite systems and NOAA TMs AVHRR data sets at a 30 km effective resolution. This new version aims to provide a new and improved satellite calibration at an effective 10 km resolution. Thus, working with SUNY, NASA will develop and test an improved production system that will enable NREL to continually update the Earth TM solar resource. Objective and Methods: In this presentation, we provide a general overview of this project together with samples of the new solar irradiance mapped data products and comparisons to surface measurements at various locations across the world. An assessment of the solar resource values relative to calibration uncertainty and assumptions are presented. Errors resulting assumptions in snow cover and background aerosol amount are described. These uncertainties and the statistics of the agreement between the measurements and new satellite estimates are also reviewed and compared to other solar data sets. Findings and Conclusions: Preliminary results show that insolation values show an overall small bias (less than 1%) with a RMS of 25% relative to surface measurements. Exceptions at certain locations were found and will be discussed relative to the uncertainties identified above. Lastly, we will identify the next steps in the development and improvement of this production system including some accuracy goals in preparation for ultimate delivery to NREL.
    Keywords: Meteorology and Climatology
    Type: NF1676L-21915 , International Conference on Energy and Meteorology (ICEM) 2015; Jun 22, 2015 - Jun 26, 2015; Boulder, CO; United States
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    NASA TECHNICAL REPORTS
  • 8
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    Progress Towards Deriving an Improved Long-Term Global Solar Resource (2013)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: This paper describes an ongoing project to provide the National Renewable Energy Laboratory (NREL) with a global long-term advanced global solar mapping production system for improved depiction of historical solar resources and to provide a mechanism for continual updates. This new production system is made possible by the efforts of NASA and NOAA to completely reprocess the International Satellite Cloud Climatology Project (ISCCP) data set that provides satellite visible and infrared radiances together with retrieved cloud and surface properties on a 10 km, 3-hourly basis beginning July 1983. We provide a general overview of this project, samples of the new solar irradiance mapped data products, and comparisons to surface measurements. Samples of the use of the SUNY-Albany solar irradiance algorithm applied to the ISCCP data show very good agreement with high quality surface measurements. We identify the next steps in the production of the data set.
    Keywords: Meteorology and Climatology
    Type: NF1676L-16442 , SOLAR 2013; Apr 16, 2013 - Apr 20, 2013; Baltimore, MD; United States
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    NASA TECHNICAL REPORTS
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