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  • Man/System Technology and Life Support  (4)
  • Homeostasis  (2)
  • 2005-2009  (6)
  • 2009  (6)
  • 1
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    The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-12-08
    Description: The molecular mechanisms that achieve homeostatic stabilization of neural function remain largely unknown. To better understand how neural function is stabilized during development and throughout life, we used an electrophysiology-based forward genetic screen and assessed the function of more than 250 neuronally expressed genes for a role in the homeostatic modulation of synaptic transmission in Drosophila. This screen ruled out the involvement of numerous synaptic proteins and identified a critical function for dysbindin, a gene linked to schizophrenia in humans. We found that dysbindin is required presynaptically for the retrograde, homeostatic modulation of neurotransmission, and functions in a dose-dependent manner downstream or independently of calcium influx. Thus, dysbindin is essential for adaptive neural plasticity and may link altered homeostatic signaling with a complex neurological disease.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063306/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063306/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dickman, Dion K -- Davis, Graeme W -- NS39313/NS/NINDS NIH HHS/ -- R01 NS039313/NS/NINDS NIH HHS/ -- R01 NS039313-12/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2009 Nov 20;326(5956):1127-30. doi: 10.1126/science.1179685.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965435" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/metabolism ; Calcium Channels/genetics/metabolism ; Carrier Proteins/genetics ; Drosophila Proteins/genetics/metabolism ; Drosophila melanogaster/*genetics/*physiology ; Dystrophin-Associated Proteins ; Genes, Insect ; Glutamic Acid/metabolism ; Homeostasis ; Humans ; Mutation ; Neuromuscular Junction/physiology ; Neuronal Plasticity ; Schizophrenia/genetics ; Synapses/*physiology/ultrastructure ; *Synaptic Transmission ; Synaptic Vesicles/metabolism ; Transgenes
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Proteasomal regulation of the hypoxic response modulates aging in C. elegans (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-04-18
    Description: The Caenorhabditis elegans von Hippel-Lindau tumor suppressor homolog VHL-1 is a cullin E3 ubiquitin ligase that negatively regulates the hypoxic response by promoting ubiquitination and degradation of the hypoxic response transcription factor HIF-1. Here, we report that loss of VHL-1 significantly increased life span and enhanced resistance to polyglutamine and beta-amyloid toxicity. Deletion of HIF-1 was epistatic to VHL-1, indicating that HIF-1 acts downstream of VHL-1 to modulate aging and proteotoxicity. VHL-1 and HIF-1 control longevity by a mechanism distinct from both dietary restriction and insulin-like signaling. These findings define VHL-1 and the hypoxic response as an alternative longevity and protein homeostasis pathway.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737476/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737476/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mehta, Ranjana -- Steinkraus, Katherine A -- Sutphin, George L -- Ramos, Fresnida J -- Shamieh, Lara S -- Huh, Alexander -- Davis, Christina -- Chandler-Brown, Devon -- Kaeberlein, Matt -- 1R01AG031108-01/AG/NIA NIH HHS/ -- P30AG013280/AG/NIA NIH HHS/ -- R01 AG031108/AG/NIA NIH HHS/ -- R01 AG031108-01A1/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2009 May 29;324(5931):1196-8. doi: 10.1126/science.1173507. Epub 2009 Apr 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Washington, Seattle, WA 98195, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19372390" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/*physiology ; Amyloid beta-Peptides/toxicity ; Animals ; Caenorhabditis elegans/genetics/metabolism/*physiology ; Caenorhabditis elegans Proteins/genetics/*metabolism ; Caloric Restriction ; Cullin Proteins/genetics/*metabolism ; Female ; Fertility ; Gene Expression Regulation ; Homeostasis ; Insulin/metabolism ; Longevity/physiology ; Male ; Models, Animal ; Oxygen/*physiology ; Peptides/toxicity ; Proteasome Endopeptidase Complex/*metabolism ; RNA Interference ; Receptor, Insulin/genetics/metabolism ; Signal Transduction ; Transcription Factors/genetics/*metabolism ; Ubiquitination
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Hypervelocity Impacts on ISS Handrails and Evaluation of Alternative Materials to Prevent Extravehicular Mobility Unit (EMU) Glove Damage During EVA (2009)
    In:  Other Sources
    Details
    Publication Date: 2019-07-19
    Description: During post-flight processing of STS-116, damage to crewmember Robert Curbeam's Phase VI Glove Thermal Micrometeoroid Garment was discovered. This damage consisted of: loss of RTV-157 palm pads on the thumb area on the right glove, a 0.75 inch cut in the Vectran adjacent to the seam and thumb pad (single event cut), constituting the worst glove damage ever recorded for the U.S. space program. The underlying bladder and restraint were found not be damaged by this event. Evaluation of glove damage found that the outer Vectran fibers were sliced as a result of contact with a sharp edge or pinch point rather than general wear or abrasion (commonly observed on the RTV pads). Damage to gloves was also noted on STS-118 and STS-120. One potential source of EMU glove damages are sharp crater lips on external handrails, generated by micrometeoroid and orbital debris (MMOD) impacts. In this paper, the results of a hypervelocity impact (HVI) test program on representative and actual ISS handrails are presented. These tests were performed in order to characterize impact damage profiles on ISS handrails and evaluate alternatives for limiting risk to future missions. It was determined that both penetrating and non-penetrating MMOD impacts on aluminum and steel ISS handrails are capable of generating protruding crater profiles which exceed the heights required for EMU glove abrasion risk by an order of magnitude. Testing demonstrated that flexible overwraps attached to the outside of existing handrails are capable of limiting contact between hazardous crater formations and crewmember gloves during extravehicular activity (EVA). Additionally, replacing metallic handrails with high strength, low ductility, fiber reinforced composite materials would limit the formation of protruding crater lips on new ISS modules.
    Keywords: Man/System Technology and Life Support
    Type: JSC-17548 , 5th European Conference on Space Debris; Mar 30, 2009 - Apr 02, 2009; Darmstadt; Germany
    Format: text
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  • 4
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    Auto-Generated Semantic Processing Services (2009)
    In:  CASI
    Details
    Publication Date: 2019-07-12
    Description: Auto-Generated Semantic Processing (AGSP) Services is a suite of software tools for automated generation of other computer programs, denoted cross-platform semantic adapters, that support interoperability of computer-based communication systems that utilize a variety of both new and legacy communication software running in a variety of operating- system/computer-hardware combinations. AGSP has numerous potential uses in military, space-exploration, and other government applications as well as in commercial telecommunications. The cross-platform semantic adapters take advantage of common features of computer- based communication systems to enforce semantics, messaging protocols, and standards of processing of streams of binary data to ensure integrity of data and consistency of meaning among interoperating systems. The auto-generation aspect of AGSP Services reduces development time and effort by emphasizing specification and minimizing implementation: In effect, the design, building, and debugging of software for effecting conversions among complex communication protocols, custom device mappings, and unique data-manipulation algorithms is replaced with metadata specifications that map to an abstract platform-independent communications model. AGSP Services is modular and has been shown to be easily integrable into new and legacy NASA flight and ground communication systems.
    Keywords: Man/System Technology and Life Support
    Type: KSC-13072 , NASA Tech Briefs, May 2009; 15
    Format: application/pdf
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  • 5
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    Space Flight Human System Standards (SFHSS) (2009)
    In:  CASI
    Details
    Publication Date: 2019-08-13
    Description: This viewgraph presentation reviews the standards for space flight hardware based on human capabilities and limitations. The contents include: 1) Scope; 2) Applicable documents; 3) General; 4) Human Physical Characteristics and Capabilities; 5) Human Performance and Cognition; 6) Natural and Induced Environments; 7) Habitability Functions; 8) Architecture; 9) Hardware and Equipment; 10) Crew Interfaces; 11) Spacesuits; 12) Operatons: Reserved; 13) Ground Maintenance and Assembly: Reserved; 14) Appendix A-Reference Documents; 15) Appendix N-Acronyms and 16) Appendix C-Definition. Volume 2 is supported by the Human Integration Design Handbook (HIDH)s.
    Keywords: Man/System Technology and Life Support
    Type: JSC-CN-18589 , NASA Advisory Council Meeting; Jul 14, 2009 - Jul 15, 2009; Washington, DC; United States
    Format: application/pdf
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  • 6
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    Oxygen Compatibility of Brass-Filled PTFE Compared to Commonly Used Fluorinated Polymers for Oxygen Systems (2009)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: Safe and reliable seal materials for high-pressure oxygen systems sometimes appear to be extinct species when sought out by oxygen systems designers. Materials that seal well are easy to find, but these materials are typically incompatible with oxygen, especially in cryogenic liquid form. This incompatibility can result in seals that leak, or much worse, seals that easily ignite and burn during use. Materials that are compatible with oxygen are easy to find, such as the long list of compatible metals, but these metallic materials are limiting as seal materials. A material that seals well and is oxygen compatible has been the big game in the designer's safari. Scientists at the Materials Combustion Research Facility (MCRF), part of NASA/Marshall Space Flight Center (MSFC), are constantly searching for better materials and processes to improve the safety of oxygen systems. One focus of this effort is improving the characteristics of polymers used in the presence of an oxygen enriched environment. Very few systems can be built which contain no polymeric materials; therefore, materials which have good impact resistance, low heat of combustion, high auto-ignition temperature and that maintain good mechanical properties are essential. The scientists and engineers at the Materials Combustion Research Facility, in cooperation with seal suppliers, are currently testing a new formulation of polytetrafluoroethylene (PTFE) with Brass filler. This Brass-filled PTFE is showing great promise as a seal and seat material for high pressure oxygen systems. Early research has demonstrated very encouraging results, which could rank this material as one of the best fluorinated polymers ever tested. This paper will compare the data obtained for Brass-filled PTFE with other fluorinated polymers, such as TFE-Teflon (PTFE) , Kel-F 81, Viton A, Viton A-500, Fluorel , and Algoflon . A similar metal filled fluorinated polymer, Salox-M , was tested in comparison to Brass-filled PTFE to demonstrate the importance of the metal chosen and relative percentage of filler. General conclusions on the oxygen compatibility of this formulation are drawn, with an emphasis on comparing and contrasting the materials performance to the performance of the current state-of-the-art oxygen compatible polymers.
    Keywords: Man/System Technology and Life Support
    Type: M09-0199 , 12th International Symposium on Flammability and Sensitivity on Materital in Oxygen Enriched Atmospheres; Oct 07, 2009 - Oct 09, 2009; Berlin; Germany
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