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  • 1
    Publication Date: 2002-10-12
    Description: A goal in visual neuroscience is to reveal how the visual system reconstructs the three-dimensional (3D) representation of the world from two-dimensional retinal images. Although the importance of texture gradient cues in the process of 3D vision has been pointed out, most studies concentrate on the neural process based on binocular disparity. We report the neural correlates of depth perception from texture gradient in the cortex. In the caudal part of the lateral bank of intraparietal sulcus, many neurons were selective to 3D surface orientation defined by texture gradient, and their response was invariant over different types of texture pattern. Most of these neurons were also sensitive to a disparity gradient, suggesting that they integrate texture and disparity gradient signals to construct a generalized representation of 3D surface orientation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tsutsui, Ken-Ichiro -- Sakata, Hideo -- Naganuma, Tomoka -- Taira, Masato -- New York, N.Y. -- Science. 2002 Oct 11;298(5592):409-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, Nihon University School of Medicine, Tokyo 173-8610, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12376700" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping ; Cues ; Depth Perception/*physiology ; Electrophysiology ; Form Perception/*physiology ; Learning ; Macaca ; Male ; Neurons/*physiology ; Parietal Lobe/*physiology ; Pattern Recognition, Visual ; Photic Stimulation ; Task Performance and Analysis ; Vision Disparity ; Visual Pathways/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1999-05-15
    Description: The mammalian hippocampus contains the neural circuitry that is crucial for cognitive functions such as learning and memory. The development of such circuitry is dependent on the generation and correct placement of the appropriate number and types of neurons. Mice lacking function of the LIM homeobox gene Lhx5 showed a defect in hippocampus development. Hippocampal neural precursor cells were specified and proliferated, but many of them failed to either exit the cell cycle or to differentiate and migrate properly. Lhx5 is therefore essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhao, Y -- Sheng, H Z -- Amini, R -- Grinberg, A -- Lee, E -- Huang, S -- Taira, M -- Westphal, H -- New York, N.Y. -- Science. 1999 May 14;284(5417):1155-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10325223" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Patterning ; Cell Differentiation ; Cell Division ; Cell Movement ; Crosses, Genetic ; Dentate Gyrus/cytology/embryology ; Female ; Gene Deletion ; Gene Expression ; *Genes, Homeobox ; Hippocampus/*cytology/*embryology ; Homeodomain Proteins/*genetics/physiology ; Interneurons/cytology ; LIM-Homeodomain Proteins ; Male ; Mice ; Morphogenesis ; Nerve Tissue Proteins/*genetics/physiology ; Neuroglia/cytology ; Neurons/*cytology ; Pyramidal Cells/cytology ; Stem Cells/*cytology ; Transcription Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 1989-07-07
    Description: The insulin receptor has an intrinsic tyrosine kinase activity that is essential for signal transduction. A mutant insulin receptor gene lacking almost the entire kinase domain has been identified in an individual with type A insulin resistance and acanthosis nigricans. Insulin binding to the erythrocytes or cultured fibroblasts from this individual was normal. However receptor autophosphorylation and tyrosine kinase activity toward an exogenous substrate were reduced in partially purified insulin receptors from the proband's lymphocytes that had been transformed by Epstein-Barr virus. The insulin resistance associated with this mutated gene was inherited by the proband from her mother as an apparently autosomal dominant trait. Thus a deletion in one allele of the insulin receptor gene may be at least partly responsible for some instances of insulin-resistant diabetes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taira, M -- Hashimoto, N -- Shimada, F -- Suzuki, Y -- Kanatsuka, A -- Nakamura, F -- Ebina, Y -- Tatibana, M -- Makino, H -- New York, N.Y. -- Science. 1989 Jul 7;245(4913):63-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Second Department of Internal Medicine, Chiba University School of Medicine, Inohana, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2544997" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Alleles ; Amino Acid Sequence ; Base Sequence ; *Chromosome Deletion ; Diabetes Mellitus, Type 1/enzymology/*genetics ; Female ; *Genes ; Humans ; Insulin Resistance ; Male ; Molecular Sequence Data ; Mutation ; Pedigree ; Protein-Tyrosine Kinases/*genetics ; Receptor, Insulin/*genetics ; Restriction Mapping
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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