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  • 1
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    Obesity drug pipeline not so fat (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-02-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, Trisha -- New York, N.Y. -- Science. 2003 Feb 7;299(5608):849-52.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12574616" target="_blank"〉PubMed〈/a〉
    Keywords: Agouti-Related Protein ; Animals ; Anti-Obesity Agents/adverse effects/pharmacology/*therapeutic use ; Appetite/drug effects ; Arcuate Nucleus of Hypothalamus/metabolism ; Ciliary Neurotrophic Factor/therapeutic use ; Clinical Trials as Topic ; Cyclobutanes/adverse effects/therapeutic use ; Energy Intake ; Ghrelin ; Humans ; Hunger/drug effects ; Intercellular Signaling Peptides and Proteins ; Lactones/adverse effects/therapeutic use ; Leptin/metabolism/therapeutic use ; Mice ; Nerve Tissue Proteins/adverse effects/therapeutic use ; Neurons/metabolism ; Neuropeptide Y/metabolism/pharmacology ; Obesity/*drug therapy/metabolism ; Peptide Fragments ; Peptide Hormones/metabolism/pharmacology ; Peptide YY/metabolism/pharmacology ; Phentermine/adverse effects/therapeutic use ; Proteins/metabolism ; Receptors, Corticotropin/metabolism ; Receptors, Melanocortin ; Weight Loss ; alpha-MSH/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Obesity research. Pot-bellied mice point to obesity enzyme (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 2001 Dec 7;294(5549):2071-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11739926" target="_blank"〉PubMed〈/a〉
    Keywords: 11-beta-Hydroxysteroid Dehydrogenase Type 2 ; Abdomen ; Adipose Tissue/*enzymology/metabolism ; Animals ; Body Composition ; Diabetes Mellitus/enzymology/metabolism ; Enzyme Inhibitors/pharmacology ; Humans ; Hydrocortisone/blood/*metabolism ; Hydroxysteroid Dehydrogenases/antagonists & inhibitors/genetics/*metabolism ; Hypoglycemic Agents/pharmacology ; Male ; Metabolic Syndrome X ; Mice ; Mice, Transgenic ; Obesity/*enzymology/genetics/metabolism ; Skin
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Gene defect linked to Rett syndrome (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 1999 Oct 1;286(5437):27.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10532886" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Chromosomal Proteins, Non-Histone ; Chromosome Mapping ; DNA-Binding Proteins/*genetics ; Female ; *Gene Expression Regulation ; Humans ; Male ; Methyl-CpG-Binding Protein 2 ; Mice ; Mice, Knockout ; Mutation ; Repressor Proteins/*genetics ; Rett Syndrome/*genetics ; X Chromosome/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    How embryos may avoid immune attack (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-09-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 1998 Aug 21;281(5380):1122-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9735025" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Embryo, Mammalian/*immunology ; Enzyme Inhibitors/pharmacology ; Female ; Humans ; *Immune Tolerance ; Male ; Mice ; Placenta/enzymology ; Pregnancy ; T-Lymphocytes/*immunology/metabolism ; Trophoblasts/*enzymology ; Tryptophan/analogs & derivatives/*metabolism/pharmacology ; Tryptophan Oxygenase/antagonists & inhibitors/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Obesity research. New data on appetite-suppressing peptide challenge critics (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, Trisha -- New York, N.Y. -- Science. 2004 Nov 26;306(5701):1453-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15567820" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Appetite/*drug effects ; Appetite Depressants/administration & dosage/*pharmacology ; Body Weight/drug effects ; Dose-Response Relationship, Drug ; Gastric Emptying/drug effects ; Humans ; Macaca mulatta ; Peptide Fragments ; Peptide YY/administration & dosage/metabolism/*pharmacology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Obesity research. Labs fail to reproduce protein's appetite-suppressing effects (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-07-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, Trisha -- New York, N.Y. -- Science. 2004 Jul 9;305(5681):158-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15247441" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Appetite/*drug effects ; Appetite Depressants/administration & dosage/*pharmacology ; Clinical Trials as Topic ; Humans ; Peptide Fragments ; Peptide YY/administration & dosage/chemistry/*pharmacology/physiology ; Publishing ; Rats ; Reproducibility of Results ; Stress, Physiological ; Weight Gain/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Having it all (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-02-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, Trisha -- New York, N.Y. -- Science. 2003 Feb 7;299(5608):850.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12574617" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Obesity Agents/administration & dosage/metabolism/*pharmacology ; Clinical Trials as Topic ; Female ; Humans ; Male ; Mice ; Penile Erection/drug effects ; Peptides, Cyclic/administration & dosage/metabolism/*pharmacology ; Receptors, Corticotropin/*antagonists & inhibitors/*metabolism ; Receptors, Melanocortin ; Skin Pigmentation/drug effects ; alpha-MSH/administration & dosage/*analogs & derivatives/metabolism/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Rare diseases: Genomics, plain and simple (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-03-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, Trisha -- England -- Nature. 2012 Feb 29;483(7387):20-2. doi: 10.1038/483020a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22382959" target="_blank"〉PubMed〈/a〉
    Keywords: Amish/genetics ; Consanguinity ; Early Diagnosis ; Female ; *Founder Effect ; Genomics/trends ; Humans ; Infant ; Infant, Newborn ; Male ; Pennsylvania ; *Precision Medicine/methods/trends ; Rare Diseases/*diagnosis/*genetics/therapy
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 9
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    Estrogen: key player in heart disease among women (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-08-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 1995 Aug 11;269(5225):771-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7543696" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arteries/physiology ; Blood Coagulation ; Estrogen Replacement Therapy ; Estrogens/*physiology ; Female ; Heart Diseases/epidemiology/etiology/*prevention & control ; Humans ; Lipoproteins, HDL/blood ; Lipoproteins, LDL/blood ; Male ; Neovascularization, Pathologic ; Randomized Controlled Trials as Topic ; Sex Characteristics ; Vasodilation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Mouse model for pregnancy problem? (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-11-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 1996 Nov 8;274(5289):922.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8966572" target="_blank"〉PubMed〈/a〉
    Keywords: Angiotensin II/metabolism ; Angiotensinogen/genetics/metabolism ; Animals ; Blood Pressure ; Crosses, Genetic ; *Disease Models, Animal ; Female ; Humans ; *Hypertension/physiopathology ; Male ; Mice ; Mice, Transgenic ; Placenta/metabolism ; Pregnancy ; *Pregnancy Complications, Cardiovascular/physiopathology ; Renin/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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