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  • 1
    Electronic Resource
    Electronic Resource
    Genetic control of the enzymatic formation of cyclic monoterpenoids in Perilla frutescens
    Amsterdam : Elsevier
    Phytochemistry 31 (1991), S. 139-142 
    Details
    ISSN: 0031-9422
    Keywords: Labiatae ; Perilla frutescens ; chemotypes ; cyclic monoterpenoids ; cyclization ; genetic control. ; geranylpyrophosphate synthase ; limonene synthase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9422(91)83022-D
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  • 2
    Electronic Resource
    Electronic Resource
    Genetic control of the chemical composition of volatile oils in Perilla frutescens
    Amsterdam : Elsevier
    Phytochemistry 25 (1986), S. 859-863 
    Details
    ISSN: 0031-9422
    Keywords: Labiatae ; Perilla frutescens ; chemotype ; gene analysis ; hybridization ; multiple alleles. ; volatile oil
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9422(86)80017-6
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  • 3
    Electronic Resource
    Electronic Resource
    Genetic control of isoegomaketone formation in perilla frutescens
    Amsterdam : Elsevier
    Phytochemistry 25 (1986), S. 2656-2657 
    Details
    ISSN: 0031-9422
    Keywords: Labiatae ; Perilta frutescens ; chemotype ; gene analysis ; isoegomaketone. ; perillaketone ; volatile oil
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0031-9422(00)84531-8
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  • 4
    Electronic Resource
    Electronic Resource
    Genetic control of phenylpropanoids in Perilla frutescens
    Amsterdam : Elsevier
    Phytochemistry 25 (1986), S. 2085-2087 
    Details
    ISSN: 0031-9422
    Keywords: Labiatae ; Perilla frutescens ; chemotype ; dillapiole. ; elemicin ; gene analysis ; myristicin ; volatile oil
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9422(86)80070-X
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  • 5
    Electronic Resource
    Electronic Resource
    Genetic control of perillene accumulation in Perilla frutescens
    Amsterdam : Elsevier
    Phytochemistry 29 (1990), S. 2873-2875 
    Details
    ISSN: 0031-9422
    Keywords: Labiatae ; Perilla frutescens ; genetic analysis ; monoterpenoids ; perillene.
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9422(90)87094-B
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  • 6
    Electronic Resource
    Electronic Resource
    Genetic control of the enzymatic formation of cyclic monoterpenoids inPerilla frutescens
    Amsterdam : Elsevier
    Phytochemistry 31 (1992), S. 139-142 
    Details
    ISSN: 0031-9422
    Keywords: Labiatae ; Perilla frutescens ; chemotypes ; cyclic monoterpenoids ; cyclization ; genetic control ; geranylpyrophosphate synthase ; limonene synthase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0031-9422(91)83022-D
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  • 7
    Electronic Resource
    Electronic Resource
    Genetic analysis of essential oil variants inPerilla frutescens (1995)
    Springer
    Biochemical genetics 33 (1995), S. 341-348 
    Details
    ISSN: 1573-4927
    Keywords: Perilla frutescens ; Labiatae ; chemotypes ; genetic analysis ; essential oils
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A new chemotype (C type) ofPerilla frutescens (Labiatae) that accumulatestrans-citral as a main component of the essential oil in the leaf was crossed with five other chemotypes containing perillaldehyde (PA), elsholtziaketone (EK), perillaketone (PK), perillene (PL), and phenylpropanoid (PP) as their respective major components for comparison of genetic differences. The analyses of F1 and F2 progenies showed thattrans-citral is accumulated when its metabolism is blocked in the simultaneous absence of a dominant geneN, which is involved in the conversion oftrans-citral into naginataketone viacis-citral, and two polymeric genesFr 1 andFr 2 , which are involved in the conversion oftrans-citral into perillene. On the basis of new data obtained from various intercrosses involving the C type as one of the parents, the genotypes of different chemotypes as well as the sites of action of several genes controlling reaction steps in the biosynthesis of monoterpenes inPerilla have been revised.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02399932
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  • 8
    Electronic Resource
    Electronic Resource
    Genetic analysis of essential oil variants inPerilla frutescens (1995)
    Springer
    Biochemical genetics 33 (1995), S. 341-348 
    Details
    ISSN: 1573-4927
    Keywords: Perilla frutescens ; Labiatae ; chemotypes ; genetic analysis ; essential oils
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A new chemotype (C type) ofPerilla frutescens (Labiatae) that accumulatestrans-citral as a main component of the essential oil in the leaf was crossed with five other chemotypes containing perillaldehyde (PA), elsholtziaketone (EK), perillaketone (PK), perillene (PL), and phenylpropanoid (PP) as their respective major components for comparison of genetic differences. The analyses of F1 and F2 progenies showed thattrans-citral is accumulated when its metabolism is blocked in the simultaneous absence of a dominant geneN, which is involved in the conversion oftrans-citral into naginataketone viacis-citral, and two polymeric genesFr 1 andFr 2 , which are involved in the conversion oftrans-citral into perillene. On the basis of new data obtained from various intercrosses involving the C type as one of the parents, the genotypes of different chemotypes as well as the sites of action of several genes controlling reaction steps in the biosynthesis of monoterpenes inPerilla have been revised.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00553813
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  • 9
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    Prostaglandin D2 as a mediator of allergic asthma (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-03-17
    Description: Allergic asthma is caused by the aberrant expansion in the lung of T helper cells that produce type 2 (TH2) cytokines and is characterized by infiltration of eosinophils and bronchial hyperreactivity. This disease is often triggered by mast cells activated by immunoglobulin E (IgE)-mediated allergic challenge. Activated mast cells release various chemical mediators, including prostaglandin D2 (PGD2), whose role in allergic asthma has now been investigated by the generation of mice deficient in the PGD receptor (DP). Sensitization and aerosol challenge of the homozygous mutant (DP-/-) mice with ovalbumin (OVA) induced increases in the serum concentration of IgE similar to those in wild-type mice subjected to this model of asthma. However, the concentrations of TH2 cytokines and the extent of lymphocyte accumulation in the lung of OVA-challenged DP-/- mice were greatly reduced compared with those in wild-type animals. Moreover, DP-/- mice showed only marginal infiltration of eosinophils and failed to develop airway hyperreactivity. Thus, PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matsuoka, T -- Hirata, M -- Tanaka, H -- Takahashi, Y -- Murata, T -- Kabashima, K -- Sugimoto, Y -- Kobayashi, T -- Ushikubi, F -- Aze, Y -- Eguchi, N -- Urade, Y -- Yoshida, N -- Kimura, K -- Mizoguchi, A -- Honda, Y -- Nagai, H -- Narumiya, S -- New York, N.Y. -- Science. 2000 Mar 17;287(5460):2013-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606-8501, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10720327" target="_blank"〉PubMed〈/a〉
    Keywords: Allergens/immunology ; Animals ; Asthma/immunology/metabolism/pathology/*physiopathology ; Bronchial Hyperreactivity ; Bronchoalveolar Lavage Fluid/cytology/immunology ; Crosses, Genetic ; Female ; Gene Targeting ; Humans ; Immunoglobulin E/blood ; Interferon-gamma/metabolism ; Interleukins/metabolism ; Lung/immunology/metabolism/pathology ; Lymphocytes/immunology ; Male ; Mast Cells/metabolism ; Mice ; Mice, Inbred C57BL ; Mucus/secretion ; Ovalbumin/immunology ; Prostaglandin D2/metabolism/*physiology ; *Receptors, Immunologic ; Receptors, Prostaglandin/genetics/metabolism/*physiology ; Respiratory Mucosa/secretion
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Regulation of spermatogenesis by testis-specific, cytoplasmic poly(A) polymerase TPAP (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-10
    Description: Spermatogenesis is a highly specialized process of cellular differentiation to produce spermatozoa. This differentiation process accompanies morphological changes that are controlled by a number of genes expressed in a stage-specific manner during spermatogenesis. Here we show that in mice, the absence of a testis-specific, cytoplasmic polyadenylate [poly(A)] polymerase, TPAP, results in the arrest of spermiogenesis. TPAP-deficient mice display impaired expression of haploid-specific genes that are required for the morphogenesis of germ cells. The TPAP deficiency also causes incomplete elongation of poly(A) tails of particular transcription factor messenger RNAs. Although the overall cellular level of the transcription factor TAF10 is unaffected, TAF10 is insufficiently transported into the nucleus of germ cells. We propose that TPAP governs germ cell morphogenesis by modulating specific transcription factors at posttranscriptional and posttranslational levels.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kashiwabara, Shin-Ichi -- Noguchi, Junko -- Zhuang, Tiangang -- Ohmura, Ko -- Honda, Arata -- Sugiura, Shin -- Miyamoto, Kiyoko -- Takahashi, Satoru -- Inoue, Kimiko -- Ogura, Atsuo -- Baba, Tadashi -- New York, N.Y. -- Science. 2002 Dec 6;298(5600):1999-2002.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Applied Biochemistry, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba Science City, Ibaraki 305-8572, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12471261" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Cytoplasm/enzymology ; Female ; Gene Expression Regulation, Developmental ; Gene Targeting ; In Situ Nick-End Labeling ; Male ; Mice ; Mice, Inbred C57BL ; Mutation ; Nuclear Proteins/genetics/metabolism ; Organ Size ; Poly A/metabolism ; Polynucleotide Adenylyltransferase/genetics/*metabolism ; Protein Biosynthesis ; RNA, Messenger/*metabolism ; Spermatids/physiology ; Spermatocytes/physiology ; *Spermatogenesis ; Spermatozoa/*physiology ; Testis/*enzymology/metabolism ; Transcription Factors/genetics/metabolism ; Transcription, Genetic ; mRNA Cleavage and Polyadenylation Factors/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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