ISSN:
1573-904X
Keywords:
Kmeria duperreana
;
Magnoliaceae
;
cytotoxicity test
;
isolation
;
kmeriol
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The CHCl3-soluble fraction of a crude extract of Kmeria duperreana exhibited cytotoxic activity when tested in both KB and P388 tumor-cell cultures. Bioassay-directed fractionation led to the isolation of a cytotoxic alkaloid, liriodenine (1). Other constituents obtained from the extract included scopoletin (2), (–)-3,4,5-trimethoxyphenyl β-D-glucopyranoside (3), (+ )-syringaresinol β-D-glucopyranoside (4), and a new phenylpropanol, kmeriol (5), whose chemical structure was established through spectroscopic analysis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015969902200
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