ISSN:
1573-3904
Keywords:
complexation
;
functionalized N-alkyl residues
;
metal ions
;
MS
;
pseudotripeptides
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Seven pseudotripeptides with the common structure Bz-His-Ψ[CO-N(CH2)n-X]Gly-His-NH2 were synthesized on the solid phase using the Fmoc-strategy, trityl protection for both His residues and Boc- or -OBut-protection for N-aminoalkyl- and N-carboxyalkyl residues, respectively. Functionalized N-alkyl glycyl peptides were formed on the solid phase by amination of a bromoacetyl dipeptide. All seven pseudotripeptides are able to form chelate complexes with the metal ions Zn2+, Ni2+, Cu2+ and Co2+. The existence of monomeric 1:1 complexes for these pseudopeptides was calculated from the MW estimated by MALDI-MS and from the isotope distribution pattern estimated by ESI.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008967706734
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