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  • METEOROLOGY AND CLIMATOLOGY  (1)
  • adenine nucleotides  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Molecular and cellular biochemistry 70 (1986), S. 89-96 
    ISSN: 1573-4919
    Keywords: α-difluoromethylornithine ; S-adenosylmethionine ; adenine nucleotides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary Depletion of the putrescine and spermidine content of Ehrlich ascites tumor cells by α-difluoromethylornithine (DFMO) treatment results in at least a 1500-fold increase in the decarboxylated S-adenosylmethionine (deSAM) content. The accumulation of this adenine nucleoside occurs because of the absence of putrescine and spermidine to act as aminopropyl group acceptors in the spermidine and spermine synthase reactions and because of an increase in S-adenosylmethionine decarboxylase activity. The fact that the synthesis of deSAM continues in DFMO-treated cells makes the pathway an adenine trap. This prompted a study of the adenine nucleotide pools. High-performance liquid chromatographic analysis showed that the total adenine nucleotide pool increased, rather than decreased, as a result of DFMO treatment; the major contributors to the increase being ATP and ADP, which increased 2.6 and 1.9 times, respectively. The cellular content of other ribonucleotides increased as well, particularly that of UTP and CTP. When putrescine was added together with DFMO, the increases in cellular ribonucleotide contents were prevented, showing that they were indeed caused by polyamine depletion.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2019-07-13
    Description: Two East-Coast snowstorms of the early twentieth century, which generated massive accumulations over portions of the Atlantic coastal plain, are described. The 'Christmas Storm' of December 25-26, 1909 produced snowfalls of greater than 25 cm over most of the Northeast Corridor from Maryland to southern New England, while the 'Knickerbocker Storm' of January 27-29, 1922 produced a total of 71 cm at Washington, DC. The storms are examined by constructing surface-weather analyses based on original data; surface observations for the continental United States at 0100 and 1300 UTC are obtained from the National Climatic Data Center (NCDC), ship reports from American vessels are taken from the NCDC archives, and the 1300 UTC data is supplemented by Canadian observations and European ship reports. In spite of the vast differences in the evolutions of the storms, it is found that both produced similarly massive snowfalls, therefore, it is concluded that a wide range of synoptic conditions can give rise to major snowstorms along the East Coast.
    Keywords: METEOROLOGY AND CLIMATOLOGY
    Type: Conference on Weather Analysis and Forecasting; Oct 02, 1989 - Oct 06, 1989; Monterey, CA; United States
    Format: text
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