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  • 1
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    Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-10-03
    Description: Intraspecific chemical communication is mediated by signals called pheromones. Caenorhabditis elegans secretes a mixture of small molecules (collectively termed dauer pheromone) that regulates entry into the alternate dauer larval stage and also modulates adult behavior via as yet unknown receptors. Here, we identify two heterotrimeric GTP-binding protein (G protein)-coupled receptors (GPCRs) that mediate dauer formation in response to a subset of dauer pheromone components. The SRBC-64 and SRBC-66 GPCRs are members of the large Caenorhabditis-specific SRBC subfamily and are expressed in the ASK chemosensory neurons, which are required for pheromone-induced dauer formation. Expression of both, but not each receptor alone, confers pheromone-mediated effects on heterologous cells. Identification of dauer pheromone receptors will allow a better understanding of the signaling cascades that transduce the context-dependent effects of ecologically important chemical signals.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448937/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448937/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, Kyuhyung -- Sato, Koji -- Shibuya, Mayumi -- Zeiger, Danna M -- Butcher, Rebecca A -- Ragains, Justin R -- Clardy, Jon -- Touhara, Kazushige -- Sengupta, Piali -- F32 GM077943/GM/NIGMS NIH HHS/ -- P30 NS045713/NS/NINDS NIH HHS/ -- P30 NS45713/NS/NINDS NIH HHS/ -- R01 CA024487/CA/NCI NIH HHS/ -- R01 CA24487/CA/NCI NIH HHS/ -- R01 GM056223/GM/NIGMS NIH HHS/ -- R01 GM56223/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2009 Nov 13;326(5955):994-8. doi: 10.1126/science.1176331. Epub 2009 Oct 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19797623" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis elegans/genetics/*growth & development/*physiology ; Caenorhabditis elegans Proteins/genetics/physiology ; Calcium/metabolism ; Cell Line ; Chemoreceptor Cells/metabolism ; Cyclic AMP/metabolism ; Cyclic GMP/metabolism ; GTP-Binding Protein alpha Subunits, Gi-Go/physiology ; Gene Expression Regulation, Developmental ; Genes, Helminth ; Guanylate Cyclase/antagonists & inhibitors/metabolism ; Hexoses/chemistry/physiology ; Humans ; Mutation ; Pheromones/*physiology ; Receptors, G-Protein-Coupled ; Reproduction ; Signal Transduction ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Overview of the Mars Science Laboratory Parachute Decelerator Subsystem (2007)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: In 2010 the Mars Science Laboratory (MSL) mission will deliver NASA's largest and most capable rover to the surface of Mars. MSL will explore previously unattainable landing sites due to the implementation of a high precision Entry, Descent, and Landing (EDL) system. The parachute decelerator subsystem (PDS) is an integral prat of the EDL system, providing a mass and volume efficient some of aerodynamic drag to decelerate the entry vehicle from Mach 2 to subsonic speeds prior to final propulsive descent to the sutface. The PDS for MSL is a mortar deployed 19.7m Viking type Disk-Gap-Band (DGB) parachute; chosen to meet the EDL timeline requirements and to utilize the heritage parachute systems from Viking, Mars Pathfinder, Mars Exploration Rover, and Phoenix NASA Mars Lander Programs. The preliminary design of the parachute soft goods including materials selection, stress analysis, fabrication approach, and development testing will be discussed. The preliminary design of mortar deployment system including mortar system sizing and performance predictions, gas generator design, and development mortar testing will also be presented.
    Keywords: Lunar and Planetary Science and Exploration
    Type: IEEE Aerospace Conference; Mar 03, 2007 - Mar 10, 2007; Big Sky, MT; United States
    Format: text
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    NASA TECHNICAL REPORTS
  • 3
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    Application of Stereo PIV on a Supersonic Parachute Model (2009)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The Mars Science Laboratory (MSL) is the next step in NASA's Mars Exploration Program, currently scheduled for 2011. The spacecraft's descent into the Martian atmosphere will be slowed from Mach 2 to subsonic speeds via a large parachute system with final landing under propulsive control. A Disk-Band-Gap (DBG) parachute will be used on MSL similar to the designs that have been used on previous missions, however; the DBG parachute used by MSL will be larger (21.5 m) than in any of the previous missions due to the weight of the payload and landing site requirements. The MSL parachute will also deploy at higher Mach number (M 2) than previous parachutes, which can lead to instabilities in canopy performance. Both the increased size of the DBG above previous demonstrated configurations and deployment at higher Mach numbers add uncertainty to the deployment, structural integrity and performance of the parachute. In order to verify the performance of the DBG on MSL, experimental testing, including acquisition of Stereo Particle Imaging Velocimetry (PIV) measurements were required for validating CFD predictions of the parachute performance. A rigid model of the DBG parachute was tested in the 10x10 foot wind tunnel at GRC. Prior to the MSL tests, a PIV system had never been used in the 10x10 wind tunnel. In this paper we discuss some of the technical challenges overcome in implementing a Stereo PIV system with a 750x400 mm field-of-view in the 10x10 wind tunnel facility and results from the MSL hardshell canopy tests.
    Keywords: Lunar and Planetary Science and Exploration
    Type: AIAA Paper 2007- 0070 , E-17866 , AIAA 47th Aerospace Sciences Meeting; Jan 05, 2009 - Jan 08, 2009; Orlando, FL; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 4
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    JPL Missions Overview (2006)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: This viewgraph reviews the current missions that JPL is managing for NASA. Specifically it reviews JPL's capabilities end-to-end to implement missions, development of research and technology. It includes information on JPL's vision for space exploration and JPL's current missions It reviews the recent scientific findings. Lastly, the presentation gives an overview of the Mars Science Laboratory Mission.
    Keywords: Lunar and Planetary Science and Exploration
    Type: 23rd American Society of Engineers of Indian Origin National Convention; Sep 08, 2006 - Sep 10, 2006; Cerritos, CA; United States
    Format: text
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    NASA TECHNICAL REPORTS
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