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  • Life and Medical Sciences  (2)
  • 1
    Electronic Resource
    Electronic Resource
    The role of actin polymerization in Amoebal Chemotaxis (1986)
    New York, NY : Wiley-Blackwell
    BioEssays 5 (1986), S. 208-211 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: A very rapid cellular event that follows chemotactic stimulation of leucocyte and cellular slime mould amoebae is a massive polymerization of G to F actin and its association with the cytoskeleton. In the cellular slime moulds this event occurs within 3-5 sec of cell surface binding of chemoattractants. It is correlated with rapid pseudopodium extension and may be a cell orientation mechanism. Curiously, before an amoebae moves away in the direction of its new pseudopodium it rounds up or “cringes” for 10-20 sec, an event correlated with a massive actin depolymerization. Transduction of the chemotactic signal involves Ca2+ release from internal stores by inositol trisphosphate.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950050505
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  • 2
    Electronic Resource
    Electronic Resource
    Streamer F mutants and chemotaxis of Dictyostelium (1992)
    New York, NY : Wiley-Blackwell
    BioEssays 14 (1992), S. 473-479 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Streamer F mutants have been found to be useful tools for studying the pathway of signal transduction leading to chemotactic cell movement. The primary defect in these mutants is in the structural gene for the cyclic GMP specific phosphodiesterase. This defect allows a larger and prolonged peak of cyclic GMP to be formed in response to the chemotactic stimulus, cyclic AMP. This characteristic aberrant pattern of cyclic GMP accumulation in the streamer F mutants has been correlated with similar patterns of changes in the influx of calcium from the medium, myosin II association with the cytoskeleton, myosin phosphorylation and a decrease in speed of movement of the amoebae. From these studies a sequence of events can be deduced that leads from cell surface cyclic AMP stimulation to cell polarization prior to movement of the amoebae in response to the chemotactic stimulus.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950140708
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    Paper (German National Licenses)
    Fulltext
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