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  • 1
    Electronic Resource
    Electronic Resource
    Human genetics: The molecular challenge (1987)
    New York, NY : Wiley-Blackwell
    BioEssays 7 (1987), S. 41-45 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The 1986 Cold Spring Harbor Symposium was on the subject of human genetics; it was the first symposium at Cold Spring Harbor on this topic since 1964. In the opening remarks for the conference, Walter F. Bodmer first summarized the progress in this field since 1964. He then described what is presently known about the functional complexity of the human genome and discussed the case for a definitive characterization and sequencing of the human genome. The following is an abridged and slightly adapted version of this talk; it is reproduced courtesy of the Cold Spring Harbor Laboratory © 1987.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950070109
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  • 2
    Electronic Resource
    Electronic Resource
    On the evolutionary relationships of Drosophila melanogasterBased on a lecture delivered in September 1983, at the International Conference in Biochemical and Developmental Genetics, Kos, Greece. (1983)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 4 (1983), S. 295-312 
    Details
    ISSN: 0192-253X
    Keywords: alcohol dehydrogenase ; Drosophila ; evolution ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The gene coding for alcohol dehydrogenase (Adh) in Drosophila melanogaster maps to 2:50.1 on chromosome arm 2L. It is expressed in both larvae and adults, coding for an abundant enzyme that plays a role in the detoxification of primary and secondary alcohols. In larvae the gene is most abundantly expressed in the fat body and gut. We have recently shown [49] that the major Adh transcripts differ in larvae and adults, the major adult transcript being initiated from a promotor several hundred pairs 5′ to the promotor from which the major larval transcript is initiated. However the coding region of the “larval and adult” mRNA are identical. We discuss recent studies of the transcriptional organization Adh and compare the structure of this gene in D. melanogaster with that in other species of Drosophila. The entire Adh gene and its surrounds has been sequenced from four species of Drosophila [45,48]. This data has been used not only for the study of phylogenetic relationships, but also of the types of sequence variation seen between species. The constraints on mutational change, especially with respect to codons, will be discussed.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020040407
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  • 3
    Electronic Resource
    Electronic Resource
    How many signals does it take? (1995)
    New York, NY : Wiley-Blackwell
    BioEssays 17 (1995), S. 754-757 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Although the genetics of dorsal-ventral polarity which leads to mesoderm formation in Drosophila are understood in considerable detail, subsequent molecular mechanisms involved in patterning the mesoderm primordium into individual mesodermal subtypes are poorly understood. Two papers published recently (1,2) suggest strongly that an inductive signal from dorsal ectoderm is involved in subdividing the underlying mesoderm, and present evidence that one of the signalling factors is Decapentaplegic (Dpp), a member of the bone morphogenetic protein subgroup of the Transforming Growth Factor-β (TGF-β) super family of proteins.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950170904
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