ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Polymer and Materials Science  (21)
  • Life Sciences (General)  (6)
  • 1
    facet.materialart.
    Unknown
    Inhibited interferon production after space flight (1988)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: Several studies have been performed in our laboratories indicating that interferon production may be impaired in rodents after space flight. Using an antiorthostatic suspension model that simulates some of the effects of microgravity seen during space flight, we have shown that interferon-alpha/beta production was inhibited. The inhibition was not due solely to the stress of suspension. The inhibited interferon production was transient, as suspended animals returned to normal caging recovered the ability to produce interferon. Antiorthostatic suspension of mice also resulted in a loss of resistance to infection with the diabetogenic strain of encephalomyocarditis virus, which correlated with the drop in interferon production. In rats flown in US Space Shuttle mission SL-3, interferon-gamma production was inhibited severely when spleen cells were challenged with concanavalin-A upon return to earth. In contrast, interleukin-3 production by these cells was normal. These results suggest that immune responses may be altered after antiorthostatic modeling or space flight, and the resistance to viral infections may be especially affected.
    Keywords: Life Sciences (General)
    Type: Acta microbiologica Hungarica (ISSN 0231-4622); Volume 35; 4; 411-6
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 2
    facet.materialart.
    Unknown
    Oxidation of the skeletal muscle Ca2+ release channel alters calmodulin binding (1999)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: This study presents evidence for a close relationship between the oxidation state of the skeletal muscle Ca2+ release channel (RyR1) and its ability to bind calmodulin (CaM). CaM enhances the activity of RyR1 in low Ca2+ and inhibits its activity in high Ca2+. Oxidation, which activates the channel, blocks the binding of 125I-labeled CaM at both micromolar and nanomolar Ca2+ concentrations. Conversely, bound CaM slows oxidation-induced cross-linking between subunits of the RyR1 tetramer. Alkylation of hyperreactive sulfhydryls (〈3% of the total sulfhydryls) on RyR1 with N-ethylmaleimide completely blocks oxidant-induced intersubunit cross-linking and inhibits Ca2+-free 125I-CaM but not Ca2+/125I-CaM binding. These studies suggest that 1) the sites on RyR1 for binding apocalmodulin have features distinct from those of the Ca2+/CaM site, 2) oxidation may alter the activity of RyR1 in part by altering its interaction with CaM, and 3) CaM may protect RyR1 from oxidative modifications during periods of oxidative stress.
    Keywords: Life Sciences (General)
    Type: The American journal of physiology (ISSN 0002-9513); Volume 276; 1 Pt 1; C46-53
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 3
    facet.materialart.
    Unknown
    Effect of space flight on immune responses: bone marrow cell response to colony stimulating factor and leukocyte subsets (1992)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: No abstract available
    Keywords: Life Sciences (General)
    Type: The Physiologist (ISSN 0031-9376); Volume 35; 1 Suppl; S222-3
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 4
    facet.materialart.
    Unknown
    Effect of space flight on cytokine production and other immunologic parameters of rhesus monkeys (1996)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: During a recent flight of a Russian satellite (Cosmos #2229), initial experiments examining the effects of space flight on immunologic responses of rhesus monkeys were performed to gain insight into the effect of space flight on resistance to infection. Experiments were performed on tissue samples taken from the monkeys before and immediately after flight. Additional samples were obtained approximately 1 month after flight for a postflight restraint study. Two types of experiments were carried out throughout this study. The first experiment determined the ability of leukocytes to produce interleukin-1 and to express interleukin-2 receptors. The second experiment examined the responsiveness of rhesus bone marrow cells to recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF). Human reagents that cross-reacted with monkey tissue were utilized for the bulk of the studies. Results from both studies indicated that there were changes in immunologic function attributable to space flight. Interleukin-1 production and the expression of interleukin-2 receptors was decreased after space flight. Bone marrow cells from flight monkeys showed a significant decrease in their response to GM-CSF compared with the response of bone marrow cells from nonflight control monkeys. These results suggest that the rhesus monkey may be a useful surrogate for humans in future studies that examine the effect of space flight on immune response, particularly when conditions do not readily permit human study.
    Keywords: Life Sciences (General)
    Type: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research (ISSN 1079-9907); Volume 16; 5; 409-15
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 5
    facet.materialart.
    Unknown
    Experiment K-7-23: Effect of Spaceflight on Level and Function of Immune Cells (1994)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: Two different experiments were carried out in this segment of the immunology protocol for samples received from rats flown on Cosmos 2044. Control groups included vivarium, synchronous and antiorthostatically suspended rats. In the first experiment, rat bone marrow cells were examined in Moscow for their response to recombinant murine colony stimulating factor-granulocyte / monocyte (CSF-GM). In the second experiment, rat spleen and bone marrow cells were stained in Moscow with a variety of antibodies directed against cell surface antigenic markers. These cells were preserved and shipped to the United States for analysis on a flow cytometer. The results of the studies indicated that bone marrow cells from flown and suspended rats showed a decreased response to CSF-GM as compared to bone marrow cells from control rats. Spleen cells from flown rats showed increased percentages of suppressor-cytotoxic-T and helper-T cells amongst the entire cell population. Bone marrow cells showed an increase in the percentage of helper-T cells in the myelogenous population and increased percentages of anti-asialo GM-1 bearing, interleukin-2 receptor bearing, pan-T and helper-T cells in the lymphocytic population. Cell populations from rats suspended antiorthostatically did not follow the same pattern of distribution of leukocytes as cell populations for flown rats. These results are similar, but not identical to, earlier results from Cosmos 1887, and confirm that space flight can have profound effects on immune system components and activities.
    Keywords: Life Sciences (General)
    Type: US Experiments Flown on the Soviet Biosatellite Cosmos 2044; 193-206; NASA-TM-108802
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 6
    facet.materialart.
    Unknown
    Evaluation of NASA Foodbars as a Standard Diet for Use in Short-Term Rodent Space Flight Studies (2003)
    In:  CASI
    Details
    Publication Date: 2019-07-10
    Description: A standard rodent diet for space flight must meet the unique conditions imposed by the space environment and must be nutritionally adequate since diet can influence the outcome of experiments. This paper evaluates the use of National Aeronautics and Space Administration (NASA) developed Foodbars as a standard space flight diet for rats. The Foodbar's semi-purified formulation permits criteria such as nutrient consistency, high nutrient bioavailability and flexibility of formulation to be met. Extrusion of the semi-purified diet produces Foodbars with the proper texture and a non-crumbing solid form for use in space. Treatment of Foodbar with 0.1% potassium sorbate prevents mold growth. Irradiation (15-25 kGy) prevents bacterial growth and in combination with sorbate-treatment provides added protection against mold for shelf-stability. However, during the development process, nutrient analyses indicated that extrusion and irradiation produced nutrient losses. Nutrients were adjusted accordingly to compensate for processing losses. Nutrient analysis of Foodbars continues to be performed routinely to monitor nutrient levels. It is important that the standard rodent diet provide nutrients that will prevent deficiency but also avoid excess that may mask physiological changes produced by space flight. All vitamins levels in the Foodbars, except for vitamin K conformed to or exceeded the current NRC (1995) recommendations. All indispensable amino acids in Foodbar conformed to or exceeded the NRC nutrient recommendation for mice growth and rat maintenance. However, some indispensable amino acids were slightly below recommendations for rat reproduction/growth. Short-term (18-20 d) animal feeding studies indicated that Foodbars were palatable, supported growth and maintained health in rats. Results indicated that NASA rodent Foodbars meet both the physical and nutritional criteria required to support rodents in the space environment and thus, may be used successfully as a standard diet for short-term space flight studies. However, nutritional adequacy of NASA Rodent Foodbars as a standard diet on longer duration (〉20 d) space flight missions remains to be determined.
    Keywords: Life Sciences (General)
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 7
    Electronic Resource
    Electronic Resource
    The physical chemistry of polyelectrolyte solutionsPaper presented at the meeting of the GDCh-Fachgruppe “Makromolekulare Chemie” on “Polymers and Water” in Bad Nauheim (W-Germany) on April 2/3 1984. (1984)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 123 (1984), S. 63-83 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Some physical properties of aqueous solutions containing linear, flexible, polyelectrolytes are reviewed in order to emphasize the role of charge interactions in these systems which strongly depend on the charge of the macromolecular chain and the concentration of low molar mass electrolyte in solution. Particular emphasis is put on polyelectrolyte solutions containing an excess of added salt, which from a theoretical point of view are easier to understand. Both the dilute and the semi-dilute case will be discussed. In the former the problem of the electrostatic potential around the macromolecular chain is briefly reviewed as well as the use of a wormlike chain model to derive average dimensions of polyelectrolytes in solutions. In the latter the scaling approach to concentration effects in polyelectrolyte solutions is briefly discussed. The pecularities of the semi-dilute regime in polyelectrolyte solutions is illustrated with the help of results obtained with dynamic light scattering and the time dependent decay of electric birefringence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1984.051230103
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Das Mischzeitverhalten bei sehr geringen Konzentrationen (1993)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 65 (1993), S. 68-70 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330650111
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Dielectric properties of maleic acid-ethylene copolymer in salt-free aqueous solutions (1978)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 16 (1978), S. 641-651 
    Details
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The dielectric behavior of maleic acid-ethylene copolymer solutions has been investigated at different polymer concentrations and two degrees of neutralization α′. It is shown that this behavior is analogous to that of ordinary polyacids. Also the experimental data can be explained in terms of the van der Touw-Mandel theory, but at low α′ a possible contribution from motion of negative charges (in turn related to bound proton fluctuations) has to be taken into account. The dielectric results suggest that the formation of intramolecular hydrogen bonds has an influence on the change of the average dimensions of the chain with increasing α′. This seems to be confirmed by viscosity data.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1978.180160406
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    The conformational transition in partially esterified poly-(methacrylic acid) (1964)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 80 (1964), S. 141-148 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Die Konformationsumwandlung von teilweise veresterter Polymethacrylsüre wurde mit Hilfe der potentiometrischen Titration untersucht.Es wurde gefunden, daß die Stabilität der bei kleinem Dissoziationsgrad (α) vorliegenden Form nicht vermindert wird, wenn die Zahl jener Kettenglieder, die intramolekulare Wasserstoffbrücken ausbilden können, abnimmt. Es zeigt sich vielmehr, daß die Umwandlung mit der mittleren Ladung pro Struktureinheit zusammenhängt. Dies stützt die Hypothese, wonach die bei kleinen α-Werten stabile Form eine kompaktere Struktur besitzt, die möglicherweise durch VAN DER WAALsche Wechselwirkungen zwischen den  - CH3-Gruppen stabilisiert ist.
    Notes: The conformational transition of poly-(methacrylic acid), partially esterified with dimethyl sulfate, has been studied using potentiometric titration at constant temperature.It is found that the stability of the form existing at low values of dissociation (α) is not decreased by reducing the number of groups on the chain capable of establishing intramolecular hydrogen bonds. The transition is also shown to depend on the average charge per monomeric unit. This confirms the hypothesis that the stable form at low α-values is a compact structure stabilized probably by VAN DER WAALS attractions between  - CH3 groups.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1964.020800112
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...