ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Leucine Enkephalin  (2)
  • 2000-2004  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Coupling of iminodiacetic acid with amino acid derivatives in solution and solid phase (2000)
    Springer
    International journal of peptide research and therapeutics 7 (2000), S. 331-345 
    Details
    ISSN: 1573-3904
    Keywords: ACP (65-74) ; coupling reagents ; HATU ; HBTU ; HSTU ; iminodiacetic acid ; infrared studies ; Kyotorphin ; Leucine Enkephalin ; solution and solid phase peptide synthesis ; TCFH ; TFFH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The IR studies for the preactivation step of N-protected iminodiacetic acid with different coupling reagents (TCFH, TFFH, HATU, HBTU, HSTU) were reported here and showed the formation of an anhydride as an active intermediate in case of TCFH and TFFH. The formation of a mixture of an anhydride and an active ester (-OBt,-OAt or-OSu) were observed for HBTU, HATU or HSTU coupling reagent. Dependent on the coupling conditions, acylation of N-protected iminodiacetic acid with amino acid ester or amide derivatives in solution phase gave monoor di-substituted iminodiacetic acid derivatives. Coupling of N-protected iminodiacetic acid with an amino acid or peptide attached to a solid support (PAL-PEG-PS or Wang resin) gave only the monosubstituted iminodiacetic acid derivatives.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02443597
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Coupling of iminodiacetic acid with amino acid derivatives in solution and solid phase (2000)
    Springer
    International journal of peptide research and therapeutics 7 (2000), S. 331-345 
    Details
    ISSN: 1573-3904
    Keywords: ACP(65–74) ; coupling reagents ; HATU ; HBTU ; HSTU ; iminodiacetic acid ; infrared studies ; Kyotorphin ; Leucine Enkephalin ; solution and solid phase peptide synthesis ; TCFH ; TFFH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The IR studies for the preactivation step of N-protected iminodiacetic acid with different coupling reagents (TCFH,TFFH, HATU, HBTU, HSTU) were reported here and showed theformation of an anhydride as an active intermediate in caseof TCFH and TFFH. The formation of a mixture of an anhydrideand an active ester (–OBt, –OAt or –OSu) were observed forHBTU, HATU or HSTU coupling reagent. Dependent on the couplingconditions, acylation of N-protected iminodiacetic acid with amino acid ester or amide derivatives in solution phase gavemono- or di-substituted iminodiacetic acid derivatives. Couplingof N-protected iminodiacetic acid with an amino acid or peptideattached to a solid support (PAL-PEG-PS or Wang resin) gave onlythe monosubstituted iminodiacetic acid derivatives.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1013070110762
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...