Publication Date:
2012-07-25
Description:
There are several different mechanisms by which antioxidants induce DNA damage in cultured cells. In a Letter to the Editor, Kojo (1) suggests that one of these mechanisms, the generation of hydrogen peroxide (H2O2) resulting from the exposure of antioxidants to high levels of oxygen in cell culture media, could be primarily responsible for the DNA damage and cell death observed in in vitro studies using resveratrol, genistein, and baicalein (2). Thus, the author questions whether the three antioxidants could act as genotoxins (and by extension, chemotherapeutic agents) in vivo where oxygen concentrations are low. Although this is a valid...
Keywords:
Letters
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General
Permalink