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  • LUNAR AND PLANETARY EXPLORATION  (2)
  • *Cell Physiological Phenomena  (1)
  • 1
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    A magnetic nanoprobe technology for detecting molecular interactions in live cells (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-07-05
    Description: Technologies to assess the molecular targets of biomolecules in living cells are lacking. We have developed a technology called magnetism-based interaction capture (MAGIC) that identifies molecular targets on the basis of induced movement of superparamagnetic nanoparticles inside living cells. Efficient intracellular uptake of superparamagnetic nanoparticles (coated with a small molecule of interest) was mediated by a transducible fusogenic peptide. These nanoprobes captured the small molecule's labeled target protein and were translocated in a direction specified by the magnetic field. Use of MAGIC in genome-wide expression screening identified multiple protein targets of a drug. MAGIC was also used to monitor signal-dependent modification and multiple interactions of proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Won, Jaejoon -- Kim, Mina -- Yi, Yong-Weon -- Kim, Young Ho -- Jung, Neoncheol -- Kim, Tae Kook -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):121-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994554" target="_blank"〉PubMed〈/a〉
    Keywords: Caspase 3 ; Caspases/metabolism ; Cell Line ; *Cell Physiological Phenomena ; Cell Survival ; Endocytosis ; Fluorescein-5-isothiocyanate ; Fluorescent Dyes ; HeLa Cells ; Humans ; I-kappa B Proteins/metabolism ; *Magnetics ; Microscopy, Confocal ; *Molecular Probe Techniques ; *Molecular Probes ; NF-kappa B/metabolism ; *Nanostructures ; Oligopeptides/metabolism ; Phosphorylation ; Protein Binding ; Proteins/*metabolism ; Quantum Dots ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; Streptavidin ; Tacrolimus/metabolism ; Transcription Factor RelA ; Tumor Necrosis Factor-alpha/pharmacology ; beta-Transducin Repeat-Containing Proteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Densities and vibrational distribution of H(3+) in the Jovian auroral ionosphere (1992)
    In:  Other Sources
    Details
    Publication Date: 2019-08-28
    Description: The assumption that H(3+) is in LTE in the region of the Jovian ionosphere from which the emissions originate is tested by calculating the vibrational distribution of H(3+) over the altitude range of 350 to 1500 km above the methane cloud tops. A model of the Jovian auroral ionosphere is constructed in which the neutral temperatures are enhanced over those of the midlatitude ionosphere, as suggested by observations and models of the auroral region. The energy and energy flux were found to be less than those involved in the production of the UV aurora. A computation of the densities and vibrational distribution shows that the distribution of the six lowest states of H(3+) can be determined fairly well in spite of uncertainties in the atomic and molecular data. The computed altitude profiles and vibrational distributions of H(3+) and H2 are consistent with the observations of IR emission in the 2- and 4-micron regions.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Journal of Geophysical Research (ISSN 0148-0227); 97; E4 A
    Format: text
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    NASA TECHNICAL REPORTS
  • 3
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    The Jovian ionospheric E region (1991)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: A model of the Jovian ionosphere was constructed, that includes direct photoionization of hydrocarbon molecules. A high-resolution solar spectrum was synthesized from Hinteregger's solar maximum spectrum (F79050N), and high-resolution cross sections for photoabsorption by H2 bands in the range 842 to 1116 A were constructed. Two strong solar lines and about 30 percent of the continuum flux between 912 and 1116 A penetrate below the methane homopause despite strong absorption by CH4 and H2. It is found that hydrocarbons (mainly C2H2 are ionized at a maximum rate of 55/cu cm per sec at 320 km above the ammonia cloud tops. The hydrocarbon ions produced are quickly converted to more complex hydrocarbon ions through reactions with CH4, C2H2, C2H6, and C2H4. It is found that a hydrocarbon ion layer is formed near 320 km that is about 50 km wide with a peak density in excess of 10,000/cu cm.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Geophysical Research Letters (ISSN 0094-8276); 18; 123-126
    Format: text
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    NASA TECHNICAL REPORTS
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