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  • Antibodies, Monoclonal/*immunology/therapeutic use  (1)
  • LDL  (1)
  • 1985-1989  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Lack of primary effect of sulphonylurea (glipizide) on plasma lipoproteins and insulin action in former Type 2 diabetics with attenuated insulin secretion (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 279-282 
    Details
    ISSN: 1432-1041
    Keywords: glipizide ; plasma lipoproteins ; HDL ; LDL ; cholesterol ; triglycerides ; blood glucose ; Type 2 diabetes ; insulin-dependent diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A double-blind, placebo-controlled investigation has been made into the effects of 8 weeks of glipizide treatment in diabetics previously classified as Type 2 but with subsequent attenuation of insulin secretion and thence maintained on exogenous insulin. Although all patients were exposed to therapeutic plasma concentrations of glipizide, fasting blood glucose, haemoglobin A1 and plasma lipoproteins (HDL, LDL, total cholesterol and triglycerides) did not show any consistent improvement following this treatment. It appears unlikely that SU (glipizide) has any primary effect on insulin action or on plasma lipoproteins. Its primary action is to augment insulin release and availability, so, its use should be restricted to Type 2 diabetics who retain insulin secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637562
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    Paper (German National Licenses)
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    Human monoclonal antibodies to Pf 155, a major antigen of malaria parasite Plasmodium falciparum (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-01-03
    Description: Pf 155, a protein of the human malaria parasite Plasmodium falciparum, is strongly immunogenic in humans and is believed to be a prime candidate for the preparation of a vaccine. Human monoclonal antibodies to Pf 155 were obtained by cloning B cells that had been prepared from an immune donor and transformed with Epstein-Barr virus. When examined by indirect immunofluorescence, these antibodies stained the surface of infected erythrocytes, free merozoites, segmented schizonts, and gametocytes. They bound to a major polypeptide with a relative molecular weight of 155K and to two minor ones (135K and 120K), all having high affinity for human glycophorin. The antibodies strongly inhibited merozoite reinvasion in vitro, suggesting that they might be appropriate reagents for therapeutic administration in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Udomsangpetch, R -- Lundgren, K -- Berzins, K -- Wahlin, B -- Perlmann, H -- Troye-Blomberg, M -- Carlsson, J -- Wahlgren, M -- Perlmann, P -- Bjorkman, A -- New York, N.Y. -- Science. 1986 Jan 3;231(4733):57-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3510452" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/*immunology/therapeutic use ; Antigens, Protozoan/analysis/*immunology ; Humans ; Plasmodium falciparum/*immunology ; Vaccines/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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