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  • 1
    Electronic Resource
    Electronic Resource
    Biliary excretion of diflunisal conjugates in patients with T-tube drainage (1988)
    Springer
    European journal of clinical pharmacology 34 (1988), S. 423-426 
    Details
    ISSN: 1432-1041
    Keywords: diflunisal ; glucuronide/sulphate conjugates ; T-tube patients ; biliary excretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The urinary and biliary excretion of diflunisal and its glucuronide and sulphate conjugates were studied in 10 patients following cholecystectomy. Total urinary excretion (0–24 h) was 36.6±16.4% of the 250 mg dose. Biliary excretion (0–24 h) was restricted to the phenolic and acyl glucuronides and accounted for 3.7±2.3% of the dose. An inverse relationship existed between urinary and biliary excretion of diflunisal and its conjugates. The data indicate that the reduced plasma clearance of diflunisal in patients with renal failure may, at least in part, be due to increased biliary excretion of diflunisal glucuronides followed by hydrolysis in the gut and reabsorption of diflunisal i.e. enterohepatic cycling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542448
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  • 2
    Electronic Resource
    Electronic Resource
    Adventitious shoot formation in cultures of 30-year-old Larix decidua, L. leptolepis, L. eurolepis, and L. laricina trees (1991)
    Springer
    Plant cell, tissue and organ culture 26 (1991), S. 45-51 
    Details
    ISSN: 1573-5044
    Keywords: Larch ; Larix decidua ; L. eurolepis ; L. laricina ; L. leptolepis ; mature trees ; micropropagation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Primordial shoot explants excised from buds of one Larix decidua tree, about 30 years old, produced more adventitious buds, elongating into shoots, when grown on half strength Litvay medium than when grown on other basal media. Thidiazuron and N6-benzyladenine (BA) were equally effective in adventitious bud induction. In a comparative study of 30-year-old L. decidua, L. leptolepis, L. eurolepis, and L. laricina trees, explants from L. eurolepis and L. decidua produced a high number of cultures with adventitious buds that elongated into shoots; those from L. leptolepis were less productive, and those from L. laricina failed to form adventitious buds. The highest response was obtained with material collected in August and September, and in March and April; the lowest response occurred in explants from the October collection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00116609
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