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Homeotic duplication of the pelvic body segment in regenerating tadpole tails induced by retinoic acid (1996)

Müller, G. B. ; Streicher, Johannes ; Müller, Romana J.

Springer

Development genes and evolution 206 (1996), S. 344-348

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ISSN: 1432-041X

Keywords: Key words Regeneration ; Pattern formation ; Vitamin A ; Homeosis

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract Homeosis, the ectopic formation of a body part, is one of the key phenomena that prompted the identification of the essential selector genes controlling body organization. Shared elements of such homeotic genes exist in all studied animal classes, but homeotic transformations of the same order of magnitude as in insects, such as the duplication of the thorax in Drosophila mutants, have not been described in vertebrates. Here we investigate the capacity of retinoic acid to modify tail regeneration in amphibians. We show that retinoic acid causes the formation of an additional body segment in regenerating tails of Rana temporaria tadpoles. A second pelvic section, including vertebral elements, pelvic girdle elements and limb buds, forms at the mid-tail level. This is the first report of a homeotic duplication of a whole body segment in vertebrate axial regeneration.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s004270050062

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Novel model system to study the influence of rubber compound formulation on the structure and composition of the rubber-brass interphase (1995)

Holtkamp, D. ; Elschner, A. ; Müller, G. ; [et al.]

Chichester [u.a.] : Wiley-Blackwell

Surface and Interface Analysis 23 (1995), S. 155-162

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ISSN: 0142-2421

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Physics

Notes: A model system was developed to study the influence of the rubber formulation and/or the aging conditions on the adhesion between brass and rubber. The bonding compounds were vulcanized on thin, homogeneous brass layers that had been prepared by sputtering onto special polymeric substrates; some of these compounds were steam-aged under controlled conditions subsequently. After the separation of the polymeric film, combined analytical electron microscopy (transmission electron microscopy/energy dispersive spectroscopy; TEM/EDS) and sputter neutral mass spectrometry (SNMS) analyses were performed. While the TEM/EDS studies offer a detailed insight into the morphological structure of the interphase, the SNMS depth profiles allow a rapid and reliable differentiation between various rubber formulations. With these model samples the beneficial effect of boric acid esters on the adhesion of cobalt-containing bonding compounds, which is observed in a typical short-term adhesion test after steam-aging, can be explained: boric acid esters act with cobalt salts as corrosion inhibitors for brass, preventing the growth of a thick intermediate ZnO/Zn (OH)2 layer that is the starting point for delaminations.

Additional Material: 7 Ill.