ISSN:
1432-0983
Keywords:
Key words[PSI+]
;
Prion
;
Translation termination
;
Yeast
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract The yeast non-Mendelian [PSI + ] determinant is presumed to be the manifestation of the aggregated prion-like state of the Sup35 protein. Plasmid-mediated amplification of the SUP35 gene greatly increases the frequency of Sup35p transition to this prion-like state. Here we show that the 3′-deletions of plasmid SUP35, leading to the C-terminal truncation of Sup35p, further increase the frequency of [PSI + ] induction despite a marked decrease in Sup35p expression levels. The data suggest that the presence of Sup35p N-terminal proteolytic fragments can cause [PSI + ] appearance in wild-type yeast cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002940050379
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