ISSN:
1572-8773
Keywords:
Iron-upake
;
Siderophores
;
Ferrichrome
;
Biomimetic siderophores
;
Arthrobacter flavescens
;
Zea mays
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Summary Synthetic molecules that mimic the properties of the natural siderophores promise to become powerful tools in the exploration of microbial iron(III)-uptake phenomena. Such molecules can serve as probes to (i) establish the essential structural requirements for biological action, (ii) trace alternative reaction pathways and (iii) compare receptors of different biological origins. In this article a series of synthetic ferrichrome analogs will be described. The strategy adopted for the design and synthesis of these compounds will be outlined and their properties in vitro and in vivo examined. The growth promotion activity of these compounds inArthrobacter flavescens is used to map the ferrichrome receptor surface. Their activities towardsZea mays allow us to trace the plants' reductive iron(III) uptake routes. Potential applications of modified ferrichrome analogs for the isolation of ferrichrome receptors, the generation of fluorescent probes and ultimately new families of antibiotic or antifungal agents, will also be indicated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01142550
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