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  • Articles  (408)
  • Inorganic Chemistry  (213)
  • Rats  (195)
  • 1980-1984  (362)
  • 1935-1939  (46)
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  • Articles  (408)
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  • 1
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    Epidermal growth factor immunoreactive material in the central nervous system: location and development (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-08
    Description: Epidermal growth factor (EGF) is a potent mitogen with hormonal activity in the gastrointestinal tract. Material cross-reacting with EGF was detected in the central nervous system of the developing and adult albino rat by the indirect immunofluorescence technique. High concentrations of EGF-cross-reacting material were identified in forebrain and midbrain structures of pallidal areas of the brain. These include the globus pallidus, ventral pallidum, entopeduncular nucleus, substantia nigra pars reticulata, and the islands of Calleja . Thus, EGF may represent another gut-brain peptide with potential neurotransmitter-neuromodulator functions in pallidal structures of the extrapyramidal motor systems of the brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fallon, J H -- Seroogy, K B -- Loughlin, S E -- Morrison, R S -- Bradshaw, R A -- Knaver, D J -- Cunningham, D D -- GM31609/GM/NIGMS NIH HHS/ -- NS16017/NS/NINDS NIH HHS/ -- NS19964/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1107-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6144184" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/growth & development/*physiology ; Epidermal Growth Factor/*physiology ; Fluorescent Antibody Technique ; Globus Pallidus/physiology ; Mitogens/physiology ; Neurotransmitter Agents/physiology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Hypoxic coordinate regulation of mitochondrial enzymes in mammalian cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-02-17
    Description: The effect of hypoxic exposure on various mitochondrial enzymes and on cell mitochondrial genomic content was studied in two types of mammalian cells. Hypoxia depressed the activity of six enzymes to the same degree. The kinetics of depression and of recovery during reexposure to normoxia were statistically similar for three marker enzymes. Despite the global and symmetrical decrease in enzyme activities, mitochondrial DNA remained constant. This suggests either symmetrical loss of mitochondrial enzymes from all mitochondria or complete loss of enzymes from a subpopulation of mitochondria with retention of an intact mitochondrial genome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, B J -- Robin, E D -- Tapper, D P -- Wong, R J -- Clayton, D A -- 5 R01 HL23701-14/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Feb 17;223(4637):707-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6320368" target="_blank"〉PubMed〈/a〉
    Keywords: Aerobiosis ; Anaerobiosis ; Animals ; Anoxia/physiopathology ; Citrate (si)-Synthase/genetics/*metabolism ; DNA, Mitochondrial/*genetics ; Electron Transport Complex IV/genetics/*metabolism ; Macrophages/*enzymology ; Mice ; Mitochondria/*enzymology ; Mitochondria, Muscle/*enzymology ; Oxidoreductases/genetics/*metabolism ; Oxo-Acid-Lyases/*metabolism ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Sustained intracerebroventricular infusion of brain fuels reduces body weight and food intake in rats (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: Long-term infusion of glucose, beta-hydroxybutyrate, and glycerol into the third ventricle of the rat brain caused a stabilization of body weight at a lower than normal level. Among the glucose- and glycerol-treated animals this weight loss was caused in part by temporary hypophagia. Among the animals treated with beta-hydroxybutyrate the weight loss was unaccompanied by a reduction in food intake. The results are consistent with the view that the systems controlling food intake and body weight are sensitive to the availability of brain fuels. They are not consistent however, with the view that these control systems monitor calories independently of their source.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, J D -- Wirtshafter, D -- Asin, K E -- Brief, D -- AM 26030/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):81-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7193909" target="_blank"〉PubMed〈/a〉
    Keywords: 3-Hydroxybutyric Acid ; Animals ; *Appetite Regulation/drug effects ; *Body Weight/drug effects ; Brain/drug effects/*physiology ; Circadian Rhythm ; Drinking/drug effects ; *Eating/drug effects ; Glucose/*pharmacology ; Glycerol/*pharmacology ; Hydroxybutyrates/administration & dosage/*pharmacology ; Hypothalamus/drug effects ; Injections, Intraventricular ; Male ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Hyperglycemia of diabetic rats decreased by a glucagon receptor antagonist (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-26
    Description: The glucagon analog [l-N alpha-trinitrophenylhistidine, 12-homoarginine]-glucagon (THG) was examined for its ability to lower blood glucose concentrations in rats made diabetic with streptozotocin. In vitro, THG is a potent antagonist of glucagon activation of the hepatic adenylate cyclase assay system. Intravenous bolus injections of THG caused rapid decreases (20 to 35 percent) of short duration in blood glucose. Continuous infusion of low concentrations of the inhibitor led to larger sustained decreases in blood glucose (30 to 65 percent). These studies demonstrate that a glucagon receptor antagonist can substantially reduce blood glucose levels in diabetic animals without addition of exogenous insulin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, D G -- Goebel, C U -- Hruby, V J -- Bregman, M D -- Trivedi, D -- AM21085/AM/NIADDK NIH HHS/ -- AM25318/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Feb 26;215(4536):1115-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6278587" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Diabetes Mellitus, Experimental/*drug therapy ; Glucagon/*analogs & derivatives/*antagonists & inhibitors/therapeutic use ; Hyperglycemia/*drug therapy ; Male ; Rats ; Receptors, Cell Surface/*drug effects ; Receptors, Glucagon ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Progesterone administration in vivo stimulates release of luteinizing hormone-releasing hormone in vitro (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-30
    Description: The release of luteinizing hormone-releasing hormone (LHRH) from tissue from the mediobasal hypothalamic-anterior hypothalamic-preoptic area of prepuberal female rats was measured in a perfusion system. Measurements were also made of the concentrations of LHRH in these tissue fragments and of luteinizing hormone in serum obtained when the rats were killed. Four groups of immature rats were studied: intact, ovariectomized, ovariectomized and implanted with estradiol-containing capsules, and ovariectomized rats primed with estradiol and injected with progesterone. The release of LHRH from the tissue of ovariectomized animals was significantly less than that of intact females and was not modified when the ovariectomized rats received estradiol. However, there was a four- to fivefold increase in LHRH release from tissue of ovariectomized rats primed with estradiol when they were killed 6 hours after they received an injection of progesterone. The concentrations of LHRH in tissue and of luteinizing hormone in serum varied among groups and with the time of day that the animals were killed. The interactions among luteinizing hormone, gonadal steroids, and the photoperiod seem to set the appropriate conditions for neural processes triggering a complete and normal release of luteinizing hormone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ramirez, V D -- Dluzen, D -- Lin, D -- New York, N.Y. -- Science. 1980 May 30;208(4447):1037-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6990489" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Castration ; Circadian Rhythm ; Estradiol/pharmacology ; Female ; Gonadotropin-Releasing Hormone/*metabolism ; Hypothalamus/*metabolism ; Hypothalamus, Anterior/metabolism ; Light ; Luteinizing Hormone/blood ; Preoptic Area/metabolism ; Progesterone/*pharmacology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Electronic Resource
    Electronic Resource
    Spirocyclische Titanamide mit der Diphenylsila-titanadiazacyclobutan- Baueinheit. Kristall- und Molekülstruktur von Ti[(NSiMe3)2SiPh2]2 [1]Professor Marianne Baudler zum 60. Geburtstage am 27. April 1981 gewidmet (1981)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 475 (1981), S. 56-66 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch Umsetzung der N-lithiierten Silylamine Ph2Si(NHR)2 mit SiCl4 bzw. TiBr4 wurden die spirocyclischen Amide B (R = Me, Et, i-Pr) und C (R = i-Pr, Me3Si) dargestellt und ihre Konstitution durch Analysen, 1H- und 29Si-NMR-Spektren gesichert. Von C, R = Me3Si, wurde an einem Einkristall eine Röntgenstrukturanalyse durchgeführt. Wichtige Strukturdaten sind: TiN 1,918(2) Å, SiN endocycl. 1,750(2) Å, exocycl. 1,738(2) Å, ∢ SiNTi 90,3(1)°.Spirocyclic Titanium Amides Containing the Diphenylsila-titana-diazacyclobutane Fragment. Crystal and Molecular Structure of Ti[(NSiMe3)2SiPh2]2By reaction of the N-lithiated silylamines Ph2Si(NHR)2 with SiCl4 and TiBr4, the spirocyclic amides B (R = Me, Et, i-Pr) and C (R = i-Pr, Me3Si) respectively have been prepared. Their constitutions have been confirmed by elemental analyses and by 1H and 29Si nmr spectroscopy. C, R = Me3Si, has been investigated by a single crystal x-ray structure analysis. Important structural parameters are: TiN 1.918(2) Å, SiN endocycl. 1.750(2) Å, exocycl. 1.738(2) Å, ∢ SiNTi 90.3(1)°.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19814750408
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  • 7
    Electronic Resource
    Electronic Resource
    Röntgenographische Untersuchungen an Titan(III)-Fluorverbindungen mit pyrochloverwandten Strukturen (1980)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 467 (1980), S. 187-196 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: X-Ray Studies on Titanium(III) Fluoro Compounds with Pyrochlore-related StructuresThe cubic compounds (a/pm) CsMIITiIIIF6, MII = Mg (1041.6), Ni (1043.9), Zn (1049.8), Co (1051.7), V (1052.6), Fe (1055.3), Mn (1064.9) and CsM0,5ITi1,5IIIF6, MI = K (1074.6), Rb (1080.6) were prepared. They crystallize in the modified pyrochlore structure of the RbNiCrF6 type, which is confirmed once more at single crystals of an oxide fluoride phase CsTi2X6 (X6 between O2F4 and O3F3): Space group Fd3m, a = 1028.8 pm, R = 2.6% (126 independent reflections). Further compounds CsM0,5ITi1,5IIIF6 according to their powder diagrams are orthorhombic (MI = NH4: a = 764.1, b = 767.5, c = 1087.5 pm) or monoclinic (Na: a = 737.0, b = 758.0, c = 1061.8 pm, β = 91.1°, Li: a = 1466, b = 1479, c = 1041 pm, β = 93.3°) with related, but not exactly know structures.
    Notes: Die kubischen verbindungen (a/pm) CsMIITiIIIF6, MII = Mg(1041,6), Ni(1043,9), Zn(1049,8), Co(1051,7), V(1052,6), Fe(1055,3), Mn(1064,9) und CsM0,5ITi1,5IIIF6, MI = K(1074,6), Rb(1080,6) wurden dargestellt. Sie kristallisieren in der modifizierten Pyrochlorstruktur des RbNiCrF6-Types, der an Einkristallen einer Oxidfluoridphase CsTi2X6 (X6 zwischen O2F4 und O3F3) erneut bestätigt wird: Raumgruppe Fd3m, a = 1028,8 pm, R = 2,6% (126 symmetrieunabhängige Reflexe). Weitere Verbindungen CsM0,5ITi1,5IIIF6 sind nach Pulveraufnahmen orthorhombisch (MI = NH4: a = 764,1, b = 767,5, c = 1087,5 pm) bzw. monoklin (Na: a = 737,0, b = 758,0, c = 1061,8 pm, β = 91,1°, Li: a = 1466, b = 1479, c = 1041 pm,β = 93,3°), mit verwandten, aber nicht genauer bekannten Strukturen.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19804670121
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  • 8
    Electronic Resource
    Electronic Resource
    Synthesis and Physicochemical Investigation of Nickel (II). Complexes with salicylaldehyde S-methylthiosemicarbazone (1984)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 512 (1984), S. 211-220 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Darstellung und physikochemische Untersuchung der Nickel (II)-Komplexe mit Salizylaldehyd-S-methylthiosemicarbazonSalizylaldehyd-S-methylthiosemicarbazon (H2L) bildet mit NiII in Gegenwart von NO3- und ClO4- paramagenetische bis-Ligand-Chelat-Komplexe und in Gegenwart von NCS-, CH3COO-, Py und γ-Picolin diamagnetische, quadratisch-planare mono-Ligand-Chelat-Komplexe. In den paramagnetischen Komplexen wird H2L als neutrale Molekel und auch als Monoanion (HL-) koordiniert, in diamagnetischen Komplexen ausschließlich als Monoanion, mit Ausnahme des Komplexes in Gegenwart von CH3COO-, wo sich Salizylaldehyd-S-methylthiose micarbazon als Dianion (L2-) koordiniert. Letztere Liganden entstehen infolge der Deprotonierung der NH2- neben der OH-Gruppe. Die Komplexe wurden durch Elementaranalyse, magnetische Messungen, IR, Elektronenspektren, molare Leitfähigkeit und TG-Analysen charakterisiert.
    Notes: Salicylaldehyde S-methylthiosemicarbazone (H2L) in the presence of ClO4- forms with NiII the paramagnetic octahedral bis(ligand) chelate complexes while in the presence of NCS-, CH3COO-, Py and γ-Pic it gives diamagnetic square planar mono(ligand) chelate complexes. In the paramagnetic complexes H2L is coordinated as a neutral molecule (H2L) and monoanion (HL-), and in diamagnetic ones only as a monoanion, except the complex obtained in the presence of CH3COO-, where it is coordinated as a dianion (L2-). The last form of the ligand is the result of deprotonation, besides OH-, the NH2-group. The complexes have been characterized by elemental analysis, magnetic measurements, i.r. and diffuse-reflection spectra, molar conductivity and TG analysis.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19845120522
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  • 9
    Electronic Resource
    Electronic Resource
    Bildung und Reaktionen Von Nickel(II)-Komplexen mit aminsubstituierten 1,2-Dioximen (1980)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 468 (1980), S. 153-164 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Formation and Reactions of Nickel(II) Complexes of Amine Substituted 1,2-DioximesIn solution nickel(II) with amine substituted 1,2-dioximes R2NDH2 forms neutral complexes Ni(R2NDH)2 ans cations [Ni(R2NHDH)2]2+ or (Ni(R2NDH)(R2NHDH)+. Well-crystallized salts are only obtained of the cations [Ni(R2NDH)2]2+ and anions like ClO4- and BPH4-. A red and an Orange isomere isomere of Ni(Me2NDH)2 are isolated. The reactions of the neutral species Ni(R2NDH)2 with BF3 or BEt3 yield the macrocyclic compounds [NiR2NHDBF2)2](BF4)2 or Ni(R2NDBEt2)2. Paramagnetic pyridine adducts are formed by the salts [Ni(R2NHDH)2](ClO4)2.On account of their colours and their chemical reactions the new complexes are classified into two groups differing by the stack of the individual, planar molecules in the crystal. The interdependence between the structure of the planar molecules and their stack in the crystal is discussed. The isomeres of Ni(Me2NDH)2 are assigned to different groups.
    Notes: Nickel(II) bildet in Lösung mit aminsubstituierten 1,2-Dioximen R2NDH2 Neutralkomplexe Ni(R2NDH)2 und Kationen [Ni(R2NHDH)2]2+ bzw. [Ni(R2NDH)(R2NHDH)]+. Nur die Kationen [Ni(R2NHDH)2]2+ ergeben mit Anionen wie ClO4- und BPH4 gut kristallisierende Salze. Die Reaktionen der Neutralkomplexe Ni(R2NDH)2 mit BF3 bzw. BEt3 führt zu den Makrocyclen [Ni(R2NHDBF2)2] (BF4)2 bzw. Ni(R2NDBEt2)2. Die Isolierung fester paramagnetischer Pyridinaddukte gelang im Fall der komplexen Salze [Ni(R2NHDH)2](ClO4)2.Auf Grund der Farbe und der chemischen Reaktionen werden die neuen Komplexe in zwei Gruppen eingeteilt, die sich in der Stapelfolge der planaren Einzelmoleküle Unterscheiden. Es werden die Zusammenhänge zwischen der Struktur der Einzelmoleküle und der Art der Stapelung im Kristall diskutiert. Die Isomeren des Ni(Me2NDH)2 (rot und gelb) gehören unterschiedlichen Gruppen an.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19804680119
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  • 10
    Electronic Resource
    Electronic Resource
    Kristallstrukturen von Säurehydraten und Oxoniumsalzen. XVI Zur Kenntnis der Verbindung H2TeI6 · 8 H2O (1980)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 461 (1980), S. 96-100 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Crystal Structures of Acid Hydrates and Oxonium Salts. XVI. On the Compound H2TeI6 · 8 H2OCrystals of H2TeI6 · 8H2O are obtained as dark-brown needles with a metallic lustre in incident light from solutions of tellurium iodides in concentrated hydroiodic acid on cooling. Under standard conditions the phase is stable only in contact with its saturated solution; decomposition by formation of HI, H2O, and TeI4 takes place in vacuo.H2TeI6 · 8 H2O is orthorhombic, space group Pnnm, Z = 2, with a = 12.672(15) Å, b = 10.825(14) Å, c = 8.322(8) Å. Structurally, the compound is to be described as bis(diaquooxonium)-hexaiodotellurate dihydrate, (H7O+3)2[TeI2-6] · 2 H2O. Isolated TeI2-6 octahedra are surrounded by a water structure which consists of disordered chains of hydrogen-bonded H2O and H7O+3 species.
    Notes: H2TeI6 · 8 H2O wird in Form dunkelbrauner im Auflicht metallisch glänzender Kristallnadeln aus Lösungen von Telluriodiden in konzentrierter Iodwasserstoffsäure beim Abkühlen erhalten. Unter Normalbedingungen ist die Phase nur im Kontakt mit ihrer Mutterlauge stabil; im Vakuum erfolgt quantitativ Zersetzung unter Abspaltung von HI und H2O und Bildung von TeI4.H2TeI6 · 8 H2O kristallisiert orthorhombisch, Raumgruppe Pnnm, Z = 2, mit a = 12,672(15) Å, b = 10,825(14) Å, c = 8,322(8) Å. Strukturchemisch ist die Verbindung als Bis(diaquooxonium)-hexaiodotellurat-dihydrat (H7O+3)2[TeI2-6] · 2 H2O zu beschreiben. Isolierte TeI2-6-Oktaeder sind in einer Wasserstruktur eingelagert, die aus fehlgeordneten Ketten von über Wasserstoffbrücken verknüpften H2O- und H7O+3-Spezies gebildet wird.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19804610115
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