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  • 1
    Electronic Resource
    Electronic Resource
    Dynamics of neuronal intermediate filaments: A developmental perspective (1992)
    New York, NY : Wiley-Blackwell
    Cell Motility and the Cytoskeleton 22 (1992), S. 81-91 
    Details
    ISSN: 0886-1544
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cm.970220202
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  • 2
    Electronic Resource
    Electronic Resource
    Binding and activation of plasminogen on the surface of osteosarcoma cells (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 159 (1994), S. 1-10 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Plasmin (Pm) is a broad action serine protease implicated in numerous physiological functions. In bone, Pm may play a role in growth, resorption, metastasis, and the activation of growth factors. The various components of the Pm system are known to bind and function on the cell surface of various cell types, but no pertinent data are available describing membrane-bound Pm or its zymogen, plasminogen (Pg), in either normal or neoplastic bone cells. We report here that Pg binds to the surface of the human osteosarcoma cell line MG-63 and is activated to Pm by endogenous urokinase plasminogen activator (uPA). These conclusions are based on experiments utilizing radiolabeled compounds and a cell surface proteolytic assay measuring amidolytic activity of Pm. 125I-Pg binding to cells was time dependent, saturable, reversible, and specific. Binding was characterized by a relatively low affinity (Kd ∼0.9 μM) and a high capacity (∼7.5 x 106 sites/cell). The binding of 125I-Pg was associated with lysine binding sites of the plasminogen molecule. Activation of 125I-Pg to 125I-Pm occurred on the cell surface and was dependent upon cell bound uPA, as determined by inhibitory antibodies. Binding of Pg to MG-63 monolayers represented ∼80% bound specifically to the cell surface and the remainder to the surrounding extracellular matrix. Either co-incubation with uPA or pre-incubation with Pm resulted in increased 125I-Pg binding to osteosarcoma cells. Cell surface Pm proteolytic activity was confirmed by an amidolytic chromogenic assay. Both Pm and Pg bound to cells with Pg being activated by endogenous uPA. Plasmin activated on the cell surface was partially protected from inhibition by α2-antiPm (requiring Pm lysine binding site interaction) but inhibited by aprotinin, (interacting directly with the Pm catalytic site). Resistance of cell bound Pm to α2-antiPm inhibition suggests that cell surface proteolysis can occur in the presence of a soluble Pm inhibitor known to exist in the extracellular space. Based on these results, we speculate that the various bone physiological processes implicating Pm may occur at or near the bone cell surface. © 1994 wiley-Liss, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041590102
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  • 3
    Electronic Resource
    Electronic Resource
    Human senescence (1996)
    New York, NY : Wiley-Blackwell
    BioEssays 18 (1996), S. 1009-1016 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Human life expectancy has increased dramatically through improvements in public health, housing, nutrition and general living standards. Lifespan is now limited chiefly by intrinsic senescence and its associated frailty and diseases. Understanding the biological basis of the ageing process is a major scientific challenge that will require integration of molecular, cellular, genetic and physiological approaches. This article reviews progress that has been made to date, particularly with regard to the genetic contribution to senescence and longevity, and assesses the scale of the task that remains.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950181211
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  • 4
    Electronic Resource
    Electronic Resource
    N-Methyl-N-Diäthoxyphosphorylamideo-Dervite des Hexachlorocyclotriphosphazatriens. II. Die Ammonolyse der N-Methyl-N-deäthoxyphosphorylamido-chlorcocyclotriphosphazatriene (1975)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 416 (1975), S. 169-173 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: N-Methyl-N-Diethoxyphosphorylamido Derivatives of Hexachlorocyclotriphosphazatriene. II. Ammonoloyses of N-Methyl-N-Diethoxyphosphorylamido-ChlorocyclotriphosphazatrienesMonokis-[N-methyl-N-diethroxyphosphorylamido]-pentachloro-cyclotriphospha-zatriene and 2, 4-bis-[N-methyl-N-diethoxyphosphorylamido]-2, 4, 6, 6-tetrachloro-cyclotriphosphazatriene react with gaseous ammonia at room temperature to the corresponding diamino compounds, N3P3CL4-n[NCH3P(O)(OC2H5)2]n(NH2)2, (n = 1, 2). Total Exchange of the chlorine in the N-Methyl-Ndiethoxyphosphorylamido-derivatives, N3P3CL6-n[NCH3P(O)(OC2H5)2]n, (n = a, 2, 3), takes place during the reaction with liquid ammonia. Aminophosphazenes of the type N3P3[NCH3P(O)(OC2H5)2]n(NH2)6-n, (n = 1, 2, 3), are formed. The described aminocyclotriphosphazatrienes are characterized by their melting points, elementary analyses, molecular weights and the TLC-Rf-values.
    Notes: Monokis-[N-methyl-N-diäthoxyphorylamido]-pentachloro-cyclotriphosphazatrien und 2, 4-Bis-[N-methyl-N-diäthoxyphosphorylamido]-2,4,6,6-tetrachlorocyclotriphosphazatrien reagieren mit gasförmigem Ammoniak bei Raumtemperatur zu den entsprechenden diaminoverbindungen, N3P3CL4-n[NCH3P(O)(OC2H5)2]n(NH2)2, (n = 1, 2). Vollständiger Austausch des Chlors in den N-Methyl-N-diäthoxyphosphorylamido-Derivaten, S3P3CL6-n[NCH3P(O). (OC2H5)2]n, (n = 1, 2, 3). findet bei der Umsetzung mit flüssigem ammonial Statt. Es werden dabei Aminocyclophosphazene des Typs N3P[NCH33P(O)(OC2H5)2]n(NH2)6-n, (n = 1. 2. 3) gebildet, Die beschriebenen Aminocyclophosphazatriene werden durch ihre Schmelzpunkte, Elementaranalysen, Molmassen und die dünnschichtchromatographischen Rf-Werte charakterisiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19754160208
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  • 5
    Electronic Resource
    Electronic Resource
    N-Methyl-N-diäthoxyphosphorylamido-Derivate des Hexachlorocyclotriphosphazatriens. III. NMR-spektroskopische Untersuchungen zur Konstitution der N-Methyl-N-diäthoxyphosphorylamido-chloro-cyclotriphosphazatriene (1975)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 418 (1975), S. 171-178 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: N.M.R. Spectroscopic Investigations of N-Methyl-N-diethoxyphosphorylamido-chloro-cyclotriphosphazatrienesThe high resolution 31P-n.m.r. spectroscopy provides essential informations about the molecular structure of N-methyl-N-diethoxyphosphorylamido derivatives of the hexachlorocyclotriphosphazatriene. Whereas the compound N3P3Cl4[NCH3P(O)(OC2H5)2]2 possesses nongeminal structure, are the substituents in the compound N3P3Cl3[NCH3P(O)(OC2H5)2]3 geminally arranged. The calculated 31P spectra agrees closely with the observed.The interpretation of the 1H-n.m.r. spectra corresponds with that of the 31P-n.m.r. spectra.
    Notes: Die hochauflösende 31P-NMR-Spektroskopie liefert wesentliche Informationen über die Molekülstruktur von N-Methyl-N-diäthoxyphosphorylamido-Derivaten des Hexachlorocyclotriphosphazatriens. Während die Verbindung N3P3Cl4[NCH3P(O)(OC2H5)2]2 nichtgeminale Struktur besitzt, erweist sich die Verbindung N3P3Cl3[NCH3P(O)(OC2H5)2]3 als geminales Substitutionsprodukt. Die berechneten 31P-Spektren stimmen gut mit den experimentellen überein.Die Aussagen aus den 1H-NMR-Spektren stehen mit denen aus den 31P-NMR-Spektren in Einklang.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19754180213
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  • 6
    Electronic Resource
    Electronic Resource
    NMR-spektroskopische Untersuchungen an Mercaptophosphazenen. I. Verlauf der Reaktion von Natriumethylmercaptid mit Hexachlorocyclotriphosphazatrien bzw. Octachlorocyclotetraphosphazatetraen (1979)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 448 (1979), S. 100-106 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: N.M.R. Spectroscopic Investigations of Thiophosphazenes. I. Reactions of Sodium Ethylthiolate with Hexachlorocyclotriphosphazatriene and OctachlorocyclotetraphosphazatetraeneBy reactions of hexachlorocyclotriphosphazatriene with an excess of sodium ethylthiolate as a suspension in ether all of the possible geminal derivatives N3P3Cl6-n(SEt)n; n = 1-6, are formed in different quantities. Products from reactions of octachlorocyclotetraphosphazatetraene with sodium ethylthiolate, N4P4Cl8-n(SEt)n, likewise contain all of the geminally substituted derivatives up to n = 8 with the exception of the derivatives with n = 1 and n = 7. Compounds with n = 3, 4, or 5 exist in two geminal isomers respectively. Nongeminal ethylthiochlorophosphazenes were not found by any reaction. The formed compounds were isolated by chromatographic methods and studied by 31P n.m.r. spectroscopy.
    Notes: Bei Umsetzungen von Hexachlorocyclotriphosphazatrien mit einem Überschuß an Natriumethylmercaptid in etherischer Suspension entstehen in unterschiedlichen Mengen alle denkbaren geminalen Substitutionsprodukte N3P3Cl6-n(SEt)n; n = 1-6. Im Reaktionsprodukt des Octachlorocyclotetraphosphazatetraens mit Natriumethylmercaptid, N4P4Cl8-n(SEt)n, lassen sich außer den Verbindungen mit n = 1 und n = 7 ebenfalls alle geminalen Substitutionsprodukte biz zu n = 8 nachweisen, wobei sich für die Verbindungen mit n = 3, 4, 5 jeweils beide geminalen Isomeren bilden. Nichtgeminale Mercaptochlorophosphazene waren bei keiner Umsetzung nachweisbar. Die entstandenen Verbindungen wurden säulenchromatographisch isoliert und 31P-NMR-spektroskopisch untersucht.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19794480111
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  • 7
    Electronic Resource
    Electronic Resource
    NMR-spektroskopische Untersuchungen an Mercaptophosphazenen. II. NMR-spektroskopische Untersuchungen an 15N-markierten Mercaptophosphazenen (1979)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 448 (1979), S. 107-114 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: N.M.R. Spectroscopic Investigations of Thiophosphazenes. II. N.M.R. Spectroscopic Investigations of 15N Labelled ThiophosphazenesCompletely 15N labelled compounds of the type 15N3P3Cl6-n(SR)n, R = Et or Ph; n = 0, 2, 4, or 6, and of the type 15N4P4Cl8-n(SR)n, R = Et; n = 0, 4, or 8, were prepared and investigated by means of both 31P n.m.r. spectroscopy and 15N n.m.r. spectroscopy respectively. The coupling constants 2JPP, in some cases only found by simulating the spectra, and the coupling constants 1JPN are given. The values of these coupling constants and their relation are discussed. The general tendency is visible, that with increasing coupling constant 1JPN the coupling constant 2JPP decreases. With increasing grade of substitution n the 15N chemical shifts are changed to higher fields.
    Notes: Vollständig 15N-markierte Verbindungen des Typs 15N3P3Cl6-n(SR)n, R = Et, Ph; n = 0, 2, 4, 6, und des Typs 15N4P4Cl8-n(SR)n, R = Et; n = 0, 4, 8, wurden synthetisiert und mit Hilfe der 31P-NMR-Spektroskopie und der 15N-NMR-Spektroskopie untersucht. Die Kopplungskonstanten 2Jpp, die in einigen Fällen nur auf dem Wege der Spektrensimulation gefunden werden, sowie die Kopplungskonstanten 1JPN werden angegeben und ihre jeweilige Änderung und ihr Verhältnis zueinander diskutiert. Es wird die allgemeine Tendenz sichtbar, daß bei zunehmender Kopplungskonstante 1JPN die Kopplungskonstante 2JPP abnimmt. Mit zunehmendem Substitutions-grad n ändern sich die 15N-chemischen Verschiebungen nach höherem Feld.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19794480112
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  • 8
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Temperaturabhängigkeit der 31P-chemischen Verschiebung in Trialkoxyphosphazen-N-phosphoryldialkylesternProfessor Hans-Albert Lehmann zum 60. Geburtstage am 1. Mai 1979 gewidmet (1979)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 451 (1979), S. 5-11 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Temperature Dependence Investigations of 31P Chemical Shifts of Trialkoxyphosphazene N-phosphoryldialkylestersThe 31P NMR spectra of a series of trialkoxyphosphazene-N-phosphoryldialkylesters, (RO)3P=N—P(O)(OR′)2, where R = R′ = Et; R = Et, R′ = Bu; R = Bu, R′ = Et; R = R′ = Bu; and R = R = R′ = Hex respectively, and of trichlorophosphazene-N-phosphoryldichloride were investigated at various temperatures. The temperature dependence of chemical shift of phosphorus belonging to the phosphazene group is multiplicately larger than that of phosphorus belonging to the phosphoryl group. This fact also could be confirmed for other simple phosphazene and phosphoryl compounds. As discussed this different temperature dependence of 31P chemical shift is not a consequence of the medium but of the molecular structure.
    Notes: Für eine Reihe von Trialkoxyphosphazen-N-phosphoryldialkylestern, (PO)3P=N—P(O)(OR′)2, wobei R = R′ = Et; R = Et, R′ = Bu; R = Bu, R′ = Et; R = R′ = Bu bzw. R = R′ = Hex waren, sowie für Trichlorphosphazen-N-phosphoryldichlorid wurden jeweils 31P-NMR-Spektren bei verschiedenen Temperaturen aufgenommen. Es zeigte sich, daß die Temperaturabhängigkeit der chemischen Verschiebung für den Phosphor der Phosphazen-Gruppierung um ein mehrfaches größer ist als die für den Phosphor der Phosphoryl-Gruppierung. Dies konnte auch allgemein für andere einfache Phosphazen- und Phosphoryl-Verbindungen bestätigt werden. Es wird diskutiert. daß diese unterschiedliche Temperaturabhängigkeit der 31P-chemischen Verschiebung nicht auf Medieneinflüsse, sondern auf die molekulare Struktur zurückzuführen ist.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19794510102
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  • 9
    Electronic Resource
    Electronic Resource
    NMR-spektroskopische Untersuchungen an 15N-markierten N-Phosphorylphosphazenen und Imidodiphosphorsäure-DerivatenProfessor Hans-Albert Lehmann zum 65. Geburtstage am 1. Mai 1984 gewidmet (1984)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 511 (1984), S. 7-18 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: N.M.R. Spectroscopic Studies of 15N Labelled N-Phosphorylphosphazenes and Imidodiphosphoric Acid Derivatives15N labelled compounds were prepared and investigated by means of 31P- and 15N-NMR spectroscopy. The chemical shift values δP and δN, and the coupling constants 1JPN and 2JPP are discussed and interpreted qualitatively by semiempirical quantumchemical calculations (CNDO/2) using POPLE'S ΔE-model.
    Notes: 15N-markierte Verbindungen der Substitutionsreihen wurden synthetisiert und mit Hilfe der 31P- und 15N-NMR-Spektroskopie untersucht. Die chemischen Verschiebungen δP und δN sowie die Kopplungskonstanten 1JPN und 2JPP werden diskutiert und qualitativ mit Hilfe halbempirischer quantenchemischer Rechnungen (CNDO/2) im Rahmen des POPLE-schen ΔE-Modells interpretiert.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19845110402
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  • 10
    Electronic Resource
    Electronic Resource
    NMR-spektroskopische Untersuchungen an 15N-markierten Oxocyclophosphazanen (1982)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 490 (1982), S. 121-128 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: NMR Spectroscopic Studies of 15N Labelled OxocyclophosphazanesThe completely 15N labelled cyclophosphazanes (15NMeP(OMe)O)3, (15NEtP(OEt)O)3, and (15NMeP(OMe)O)4 were prepared by rearrangement of the corresponding alkoxyphosphazenes and their 31P- and 15N-NMR spectra were investigated. On the case of the trimer compounds spectra of the ABB′XX′Y spin type were obtained; all coupling constants are relevant, and like the 15N chemical shifts they are found only by means of spectra simulations. The relative signs of the coupling constants 1JPN, 2JPP, 2JNN, and 3JPN were also obtained.
    Notes: Die vollständig 15N-markierten Cyclophosphazane (15NMeP(OMe)O)3, (15NEtP(OEt)O)3 und (15NMeP(OMe)O)4 wurden aus den entsprechenden Alkoxyphosphazenen dargestellt und sowohl 31P- als auch 15N-NMR-spektroskopisch untersucht. Bei den trimeren Verbindungen wurden Spektren vom Spintyp ABB'XX'Y erhalten; alle Kopplungskonstanten sind relevant, sie können wie die 15N-chemischen Verschiebungen nur auf dem Wege der Spektrensimulation erhalten werden. Es ergeben sich auch die relativen Vorzeichen für die Kopplungskonstanten 1JPN, 2JPP, 2JNN und 3JPN.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19824900114
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