Publication Date:
1997-10-10
Description:
Substance P is released in the spinal cord in response to painful stimuli, but its role in nociceptive signaling remains unclear. When a conjugate of substance P and the ribosome-inactivating protein saporin was infused into the spinal cord, it was internalized and cytotoxic to lamina I spinal cord neurons that express the substance P receptor. This treatment left responses to mild noxious stimuli unchanged, but markedly attenuated responses to highly noxious stimuli and mechanical and thermal hyperalgesia. Thus, lamina I spinal cord neurons that express the substance P receptor play a pivotal role in the transmission of highly noxious stimuli and the maintenance of hyperalgesia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mantyh, P W -- Rogers, S D -- Honore, P -- Allen, B J -- Ghilardi, J R -- Li, J -- Daughters, R S -- Lappi, D A -- Wiley, R G -- Simone, D A -- MH56368/MH/NIMH NIH HHS/ -- NS23970/NS/NINDS NIH HHS/ -- NS31223/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1997 Oct 10;278(5336):275-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Neurobiology Laboratory (151), Veterans Administration Medical Center, Minneapolis, MN 55417, USA. manty001@maroon.tc.umn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9323204" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Capsaicin
;
Cell Membrane/metabolism
;
Cells, Cultured
;
Fluorescent Antibody Technique
;
Hyperalgesia/physiopathology/*therapy
;
*Immunotoxins
;
Injections, Spinal
;
*N-Glycosyl Hydrolases
;
Neurons/cytology/*metabolism
;
Pain/physiopathology
;
*Pain Management
;
Pain Measurement
;
Plant Proteins/metabolism/pharmacology
;
Rats
;
Rats, Sprague-Dawley
;
Receptors, Neurokinin-1/biosynthesis/*metabolism
;
Ribosome Inactivating Proteins, Type 1
;
Signal Transduction
;
Spinal Cord/*cytology/metabolism
;
Substance P/*metabolism/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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