Publication Date:
1988-01-15
Description:
A crucial question in the study of immunological reactions in the central nervous system (CNS) concerns the identity of the parenchymal cells that function as the antigen-presenting cells in that organ. Rat bone marrow chimeras and encephalitogenic, major histocompatability--restricted T-helper lymphocytes were used to show that a subset of endogenous CNS cells, commonly termed "perivascular microglial cells," is bone marrow-derived. In addition, these perivascular cells are fully competent to present antigen to lymphocytes in an appropriately restricted manner. These findings are important for bone marrow transplantation and for neuroimmunological diseases such as multiple sclerosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hickey, W F -- Kimura, H -- KO7-NS0087/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1988 Jan 15;239(4837):290-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6079.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3276004" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigen-Presenting Cells/*immunology
;
Astrocytes/immunology
;
Bone Marrow/*immunology
;
Bone Marrow Transplantation
;
Central Nervous System/blood supply/*immunology/pathology
;
Chimera
;
Encephalomyelitis, Autoimmune, Experimental/immunology/pathology
;
Endothelium/immunology
;
Graft vs Host Disease/immunology
;
Histocompatibility Antigens/analysis/immunology
;
Immunohistochemistry
;
Multiple Sclerosis/immunology/pathology
;
Neuroglia/*immunology
;
Rats
;
Rats, Inbred Lew
;
T-Lymphocytes/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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