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  • INSTRUMENTATION AND PHOTOGRAPHY  (3)
  • gamma-Aminobutyric Acid/pharmacology  (3)
  • GEOSCIENCES (GENERAL)  (2)
  • 1
    Publication Date: 1978-05-19
    Description: Barbiturate anesthetics, but not anticonvulsants, abolish the spontaneous activity of cultured spinal cord neurons; directly increase membrane conductance, an effect which is suppressed by the gamma-aminobutyric acid (GABA) antagonists picrotoxin and penicillin; and are more potent than anticonvulsants in augmenting GABA and depressing glutamate responses. Barbiturate anticonvulsants abolish picrotoxin-induced convulsive activity. These results indicate qualitative and quantitative differences between anesthetic and anticonvulsant barbiturates, which may explain their different clinical effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macdonald, R L -- Barker, J L -- New York, N.Y. -- Science. 1978 May 19;200(4343):775-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205953" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Cells, Cultured ; Electric Conductivity ; Glutamates/pharmacology ; Membrane Potentials/drug effects ; Neurons/*drug effects ; Pentobarbital/*pharmacology ; Phenobarbital/*pharmacology ; Picrotoxin/pharmacology ; Receptors, Neurotransmitter/drug effects ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-07-25
    Description: Intracellular recordings from voltage-clamped mouse spinal neurons in tissue culture were used to study the membrane mechanisms underlying inhibitory responses to gamma-aminobutyric acid and the (-) isomer of pentobarbital. Fluctuation analysis suggested that both substances activated ion channels in the membranes. However, the channels activated by pentobarbital remained open five times longer than those activated by gamma-aminobutyric acid.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mathers, D A -- Barker, J L -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):507-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6248961" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/drug effects/physiology ; Cells, Cultured ; Ion Channels/drug effects/*physiology ; Membrane Potentials/drug effects ; Mice ; Neurons/drug effects/*physiology ; Pentobarbital/*pharmacology ; Spinal Cord/*physiology ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 1981-03-27
    Description: The binding of [3H]diazepam to benzodiazepine receptors was studied in extensively washed membranes of rat cerebral cortex in the presence of the depressant barbiturate, pentobarbital. Pentobarbital, like the endogenous neurotransmitter gamma-aminobutyric acid (GABA), increased the basal binding and also potentiated the GABA-enhanced binding of [3H]diazepam to benzodiazepine receptors by increasing the apparent affinity of [3H]diazepam for the benzodiazepine receptor. The concentrations of pentobarbital necessary to elicit these effects in vitro are the same as those observed after treatment with pharmacologically relevant doses, suggesting that a common neurochemical association may exist between these types of compounds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Skolnick, P -- Moncada, V -- Barker, J L -- Paul, S M -- New York, N.Y. -- Science. 1981 Mar 27;211(4489):1448-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6258230" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebral Cortex/drug effects ; Chlorides/metabolism ; Diazepam/metabolism ; Male ; Pentobarbital/*pharmacology ; Rats ; Receptors, Drug/*drug effects/metabolism ; Receptors, GABA-A ; Stimulation, Chemical ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2014-09-17
    Description: Relative spectral response data for the LANDSAT-4 and LANDSAT-4 backup multispectral scanner subsystems (MSS), the protoflight and flight models are presented and compared to similar data for the LANDSAT 1, 2 and 3 scanners. Channel (six channels per band) outputs for soil and soybean targets were simulated and compared within each band and between scanners. The principal differences between the spectral responses of the LANDSAT-4 scanners and previous scanners are discussed. The simulated LANDSAT-4 scanner outputs were 3 to 10 percent lower in the red band and 3 to 11 percent higher in the first near-IR band than previous scanners for the soybeans targets. The LANDSAT-4 scanners were generally more uniform from channel to channel within bands than previous scanners. In the upper-band edge of the red band of the protoflight scanner, one channel was markedly different (12 nm) from the rest. For a soybeans target, this nonuniformity resulted in a within-band difference of 6.2 percent in simulated outputs between channels.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: LANDSAT-4 Sci. Invest. Summ., Including Dec. 1983 Workshop Results, Vol. 2; p 73-75
    Format: text
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  • 5
    Publication Date: 2014-09-12
    Description: The characterization of the relative radiometric calibration of the protoflight Thematic Mapper sensor (TM/PF) is considered with focus on the variability and uncertainty of TM relative radiometry, including total variability as well as its systematic and random components. Emphasis is placed on identifying the magnitude and types of systematic errors, since these have the potential for being reduced during ground processing. Estimates of innate random variability, such as the standard deviation of a signal or its signal to noise ratio, are also important. The processing effects of radiometry are explored. Recommendations are given for engineering characterization, flight segment operations and ground processing.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: LANDSAT-4 Sci. Invest. Summ., Including Dec. 1983 Workshop Results, Vol. 1; p 140-180
    Format: text
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  • 6
    Publication Date: 2014-09-12
    Description: From both scientific and applications perspectives, the usefulness of TM digital imagery is significantly determined by its radiometric characteristics. This includes both the accuracy to which the dynamic range is known and its radiometric reproducibility or precision. Results from several pre-launch tests with a 122-cm Integrating Sphere (IS) used as part of the absolute radiometric calibration experiments for the protoflight TM sensor carried on the LANDSAT-4 satellite are summarized and analyzed. Topics covered include TM radiometric calibration and sensitivity; the TM internal calibrator; and the dynamic range after calibration.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: LANDSAT-4 Sci. Invest. Summ., Including Dec. 1983 Workshop Results, Vol. 1; p 130-139
    Format: text
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  • 7
    Publication Date: 2019-07-13
    Description: A series of brief summaries of the results of individual investigations of LANDSAT 4 image data characteristics are presented. Topics are divided into MSS and TM investigations, and applications of the imaging techniques. Radiometric and geometric accuracy are emphasized.
    Keywords: GEOSCIENCES (GENERAL)
    Type: E84-10167 , NASA-CP-2326-VOL-2 , NAS 1.55:2326-VOL-2 , LANDSAT-4 Early Results Symposium; Feb 22, 1983 - Feb 24, 1983; Greenbelt, MD; United States
    Format: application/pdf
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  • 8
    Publication Date: 2019-07-13
    Description: A general overview of the LANDSAT 4 system with emphasis on the Thematic Mapper (TM) is presented. A variety of topics on the design, calibration, capabilities, and image processing techniques of the TM sensor are discussed in detail. The comparison of TM data with other MSS data is also investigated.
    Keywords: GEOSCIENCES (GENERAL)
    Type: E84-10166 , NASA-CP-2326-VOL-1 , NAS 1.55:2326-VOL-1 , LANDSAT Sci. Characterization Workshop; Dec 06, 1983|Proc. of LANDSAT-4 Early Results Symp.; Feb 22, 1983 - Feb 24, 1983; Greenbelt, MD; United States
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