Publication Date:
1979-01-19
Description:
Intact male rats exhibited more grooming in unfamiliar testing chambers than in their home cages. Hypophysectomized rats showed a much reduced increase in grooming in these testing chambers. Intraventricular injections of antiserum to adrenocorticotropic hormone to intact rats decreased the grooming usually observed in the novel situation, whereas a similar injection of control serum did not produce this effect. Peripheral injections of the antiserum did not affect grooming. Since intraventricularly injected adrenocorticotropic hormone induces excessive grooming, these results suggest that the increased grooming observed in the novel environment may be at least partly due to the release of this hormone directly into the cerebral ventricular system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dunn, A J -- Green, E J -- Isaacson, R L -- New York, N.Y. -- Science. 1979 Jan 19;203(4377):281-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/216073" target="_blank"〉PubMed〈/a〉
Keywords:
Adrenocorticotropic Hormone/*cerebrospinal fluid/immunology/pharmacology
;
Animals
;
Antigen-Antibody Reactions
;
Grooming/drug effects/*physiology
;
Humans
;
Hypophysectomy
;
Male
;
Rats
;
Stress, Psychological
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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