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  • 1
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    Trophic conversion of an obligate photoautotrophic organism through metabolic engineering (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-06-16
    Description: Most microalgae are obligate photoautotrophs and their growth is strictly dependent on the generation of photosynthetically derived energy. We show that the microalga Phaeodactylum tricornutum can be genetically engineered to thrive on exogenous glucose in the absence of light through the introduction of a gene encoding a glucose transporter (glut1 or hup1). This demonstrates that a fundamental change in the metabolism of an organism can be accomplished through the introduction of a single gene. This also represents progress toward the use of fermentation technology for large-scale commercial exploitation of algae by reducing limitations associated with light-dependent growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zaslavskaia, L A -- Lippmeier, J C -- Shih, C -- Ehrhardt, D -- Grossman, A R -- Apt, K E -- New York, N.Y. -- Science. 2001 Jun 15;292(5524):2073-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Martek Biosciences Corp., 6480 Dobbin Road, Columbia, MD 21045, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11408656" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Transport ; Cell Line, Transformed ; Cell Membrane/metabolism ; Darkness ; Diatoms/*genetics/growth & development/*metabolism ; *Genetic Engineering ; Glucose/*metabolism ; Glucose Transporter Type 1 ; Glycolysis ; Green Fluorescent Proteins ; Humans ; Light ; Luminescent Proteins/genetics/metabolism ; Membrane Proteins/genetics/metabolism ; Microscopy, Confocal ; Molecular Weight ; Monosaccharide Transport Proteins/chemistry/*genetics/metabolism ; Photosynthesis ; Recombinant Fusion Proteins/metabolism ; Symporters ; Transformation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Women and AIDS (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-01-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chavkin, W -- Cohen, J -- Ehrhardt, A A -- Fullilove, M T -- Worth, D -- New York, N.Y. -- Science. 1991 Jan 25;251(4992):359-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1989069" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*epidemiology/prevention & control ; Female ; Humans ; United States/epidemiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-10-14
    Description: Schizophrenia is a complex illness characterized by multiple types of symptoms involving many aspects of cognition and emotion. Most efforts to identify its underlying neural substrates have focused on a strategy that relates a single symptom to a single brain region. An alternative hypothesis, that the variety of symptoms could be explained by a lesion in midline neural circuits mediating attention and information processing, is explored. Magnetic resonance images from patients and controls were transformed with a "bounding box" to produce an "average schizophrenic brain" and an "average normal brain." After image subtraction of the two averages, the areas of difference were displayed as an effect size map. Specific regional abnormalities were observed in the thalamus and adjacent white matter. An abnormality in the thalamus and related circuitry explains the diverse symptoms of schizophrenia parsimoniously because they could all result from a defect in filtering or gating sensory input, which is one of the primary functions of the thalamus in the human brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Andreasen, N C -- Arndt, S -- Swayze, V 2nd -- Cizadlo, T -- Flaum, M -- O'Leary, D -- Ehrhardt, J C -- Yuh, W T -- MH31593/MH/NIMH NIH HHS/ -- MH40856/MH/NIMH NIH HHS/ -- MHCRC 43271/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1994 Oct 14;266(5183):294-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mental Health Clinical Research Center, College of Medicine.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7939669" target="_blank"〉PubMed〈/a〉
    Keywords: Brain/pathology ; Female ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging/*methods ; Male ; Schizophrenia/*pathology ; Software ; Subtraction Technique ; Thalamus/*pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    RESEARCH ETHICS. Evidence gaps and ethical review of multicenter studies (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-11-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ervin, Ann-Margret -- Taylor, Holly A -- Meinert, Curtis L -- Ehrhardt, Stephan -- 1R01HG008558-01/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2015 Nov 6;350(6261):632-3. doi: 10.1126/science.aac4872.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. aervin@jhu.edu. ; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Johns Hopkins Berman Institute of Bioethics, Baltimore, MD, USA. ; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26542556" target="_blank"〉PubMed〈/a〉
    Keywords: Clinical Trials as Topic/*standards ; Ethical Review/*standards ; Ethics Committees, Research/*standards ; Evidence-Based Medicine/*standards ; Humans ; Multicenter Studies as Topic/*ethics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Effects of prenatal sex hormones on gender-related behavior (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-20
    Description: Gender identity depends largely on postnatal environmental influences, while sex-dimorphic behavior and temperamental sex differences appear to be modified by prenatal sex hormones. A role of the prenatal endocrine milieu in the development of erotic partner preference, as in hetero-, homo-, or bisexual orientation, or of cognitive sex differences has not been conclusively demonstrated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ehrhardt, A A -- Meyer-Bahlburg, H F -- New York, N.Y. -- Science. 1981 Mar 20;211(4488):1312-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209510" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adrenal Hyperplasia, Congenital/metabolism/psychology ; Adult ; Androgens/pharmacology ; Behavior/drug effects ; Child ; Cognition/drug effects ; Embryo, Mammalian/drug effects ; Estrogens/pharmacology ; Female ; *Gender Identity ; Gonadal Steroid Hormones/*pharmacology ; Humans ; *Identification (Psychology) ; Male ; Pregnancy ; Pregnancy Complications/drug therapy ; Progestins/pharmacology/therapeutic use ; Sexual Behavior/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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