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  • 1
    Electronic Resource
    Electronic Resource
    Spectroscopic detection of a tungsten-carbene complex derived from the tungsten hexachloride/tetramethyltin metathesis catalyst system in CD2Cl2 (1987)
    Basel : Wiley-Blackwell
    Die Makromolekulare Chemie, Rapid Communications 8 (1987), S. 269-271 
    Details
    ISSN: 0173-2803
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/marc.1987.030080603
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  • 2
    Electronic Resource
    Electronic Resource
    The use of crossflow to improve nonwoven melt-blown fibers (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 44 (1992), S. 279-288 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A stream of unheated crossflow air has been used to make finer melt-blown fibers. Not only are smaller average fiber diameters obtained, but the variation in fiber diameter is smaller. The use of this technique can allow the production of melt-blown nonwovens, which have finer fibers and more uniform webs. Since unheated air is used in the crossflow jet, the fiber enhancement in terms of finer, stronger fibers can be achieved with an energy savings by substituting unheated crossflow air for a portion of the primary air.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1992.070440212
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  • 3
    Electronic Resource
    Electronic Resource
    Empirical models for melt blowing (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 58 (1995), S. 159-163 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A large data set obtained for melt blowing using a single hole die has been used to develop empirical models which express final average fiber diameter as a function of dimensionless independent variables. The resulting empirical models or equations have been compared to multihole melt-blowing die data. The conclusion of this investigation is that appropriate first-order variables have been identified and the dependence of average final fiber diameter on the independent variables has been established. The resulting model should prove very useful for use in melt-blowing process control and in the design of melt-blowing equipment for polypropylene with an MFR between 500 and 900. © 1995 John Wiley & Sons, Inc.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1995.070580117
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  • 4
    Electronic Resource
    Electronic Resource
    Thermal transitions in reduced wool fibers (1968)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 12 (1968), S. 1992-1996 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1968.070120821
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  • 5
    Electronic Resource
    Electronic Resource
    The search for correlation between electrokinetic phenomena and blood thrombus formation on implant materials (1968)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 2 (1968), S. 51-79 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Bioelectric charge transfer at the blood-wall interface may be a crucial factor affecting thrombosis on implant materials. A program of studies was conducted to determine the electrokinetic and other physical properties of a wide spectrum of materials including organic polymers, metals, inorganics, heterogeneous compounds, and animal tissue. From these tests, materials were selected for in-vivo cannulation experiments. In this manner, a search was made to find a correlation between surface charge characteristics and thrombosis on cardiovascular implant materials. It was found that materials exhibiting a substantial positive charge were prone to rapid thrombosis. No clear correlation can be stated, as yet, regarding the thrombogenecity of highly charged negative surfaces or slightly charged surfaces. However, many heterogeneous materials have exhibited prolonged in-vivo patency. It appears necessary to isolate surface effects from volumetric effects to seek the role of bioelectric charge transfer in blood thrombus formation.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820020105
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  • 6
    Electronic Resource
    Electronic Resource
    The search for the nonthrombogenic property of colloidal graphiteThis work was supported by a grant from The John A. Hartford Foundation, Inc. (1970)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 4 (1970), S. 121-138 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The nonthrombogenic property of the graphite-Benzalkonium-heparin surface has not been consistently attained by those using this coating. In addition, there is mounting evidence that this property is not dependent entirely on the presence of heparin. A series of tests were conducted to further define the properties of colloidal graphite materials, methods of control and possible relationships to thrombus formation. These tests included electrokinetic investigations, dielectric measurements and other physical/chemical property evaluations. It was found that the colloidal graphite coating approximates many properties which are characteristic of animal tissue. However, considerable scatter in the duplication of these properties was encountered. The properties which seemed to separate the Acheson Colloids Company DAG-35 coating from other graphite products were those of porosity and permeability. Control of these parameters may be critical to achieving consistent uniform success.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820040111
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  • 7
    Electronic Resource
    Electronic Resource
    Some observations on the dielectric properties of cardiovascular implant materials (1973)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 7 (1973), S. 445-470 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Bioelectric charge transfer between blood and the vascular wall appears to play a significant role in maintaining vascular homeostasis. Since the surface charge characteristics of the vessel wall are a function of the dielectric properties of the material, a study was made of the dielectric characteristics of various ion permeable materials and their relationship to electrokinetic phenomena and thrombogenicity. The dielectric properties of the ion permeable materials and of animal tissue were determined and found to be strikingly similar. Several models of electrodiffusion phenomena are reviewed with respect to dielectric properties. The electro-osmotic characteristics of animal tissue and ion permeable materials were investigated, and it was found that animal tissue exhibited electro-osmotic characteristics to a greater degree than did any other man-made materials. The propensity of a material to electro-osmose could not be predicted from the dielectric properties. In addition, no correlation could be found between thrombogenicity and dielectric properties. Dielectric relaxation phenomena is reviewed, and its possible contribution to nonthrombogenicity through the generation of a uniform, constant wall surface charge is presented. It is concluded that to mimic the ion content and mobility characteristics of animal tissue, as determined by dielectric properties, is insufficient to preclude thrombus formation.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820070507
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  • 8
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    Identification of a serotonin/glutamate receptor complex implicated in psychosis (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-02-26
    Description: The psychosis associated with schizophrenia is characterized by alterations in sensory processing and perception. Some antipsychotic drugs were identified by their high affinity for serotonin 5-HT2A receptors (2AR). Drugs that interact with metabotropic glutamate receptors (mGluR) also have potential for the treatment of schizophrenia. The effects of hallucinogenic drugs, such as psilocybin and lysergic acid diethylamide, require the 2AR and resemble some of the core symptoms of schizophrenia. Here we show that the mGluR2 interacts through specific transmembrane helix domains with the 2AR, a member of an unrelated G-protein-coupled receptor family, to form functional complexes in brain cortex. The 2AR-mGluR2 complex triggers unique cellular responses when targeted by hallucinogenic drugs, and activation of mGluR2 abolishes hallucinogen-specific signalling and behavioural responses. In post-mortem human brain from untreated schizophrenic subjects, the 2AR is upregulated and the mGluR2 is downregulated, a pattern that could predispose to psychosis. These regulatory changes indicate that the 2AR-mGluR2 complex may be involved in the altered cortical processes of schizophrenia, and this complex is therefore a promising new target for the treatment of psychosis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743172/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743172/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gonzalez-Maeso, Javier -- Ang, Rosalind L -- Yuen, Tony -- Chan, Pokman -- Weisstaub, Noelia V -- Lopez-Gimenez, Juan F -- Zhou, Mingming -- Okawa, Yuuya -- Callado, Luis F -- Milligan, Graeme -- Gingrich, Jay A -- Filizola, Marta -- Meana, J Javier -- Sealfon, Stuart C -- G9811527/Medical Research Council/United Kingdom -- P01 DA012923/DA/NIDA NIH HHS/ -- P01 DA012923-06A10004/DA/NIDA NIH HHS/ -- T32 DA007135/DA/NIDA NIH HHS/ -- T32 DA007135-25S1/DA/NIDA NIH HHS/ -- T32 GM062754/GM/NIGMS NIH HHS/ -- England -- Nature. 2008 Mar 6;452(7183):93-7. doi: 10.1038/nature06612. Epub 2008 Feb 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA. javier.maeso@mssm.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18297054" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/cytology/metabolism ; Cell Line ; Cells, Cultured ; Down-Regulation ; Hallucinogens/metabolism/pharmacology ; Humans ; Mice ; Models, Molecular ; Multiprotein Complexes/chemistry/genetics/metabolism ; Protein Binding ; Protein Structure, Tertiary ; Psychotic Disorders/drug therapy/genetics/*metabolism ; Receptor, Serotonin, 5-HT2A/analysis/deficiency/genetics/*metabolism ; Receptors, Metabotropic Glutamate/analysis/antagonists & ; inhibitors/genetics/*metabolism ; Schizophrenia/metabolism ; Signal Transduction/drug effects ; Up-Regulation
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 9
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    TRPC channel activation by extracellular thioredoxin (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-01-04
    Description: Mammalian homologues of Drosophila melanogaster transient receptor potential (TRP) are a large family of multimeric cation channels that act, or putatively act, as sensors of one or more chemical factor. Major research objectives are the identification of endogenous activators and the determination of cellular and tissue functions of these channels. Here we show the activation of TRPC5 (canonical TRP 5) homomultimeric and TRPC5-TRPC1 heteromultimeric channels by extracellular reduced thioredoxin, which acts by breaking a disulphide bridge in the predicted extracellular loop adjacent to the ion-selectivity filter of TRPC5. Thioredoxin is an endogenous redox protein with established intracellular functions, but it is also secreted and its extracellular targets are largely unknown. Particularly high extracellular concentrations of thioredoxin are apparent in rheumatoid arthritis, an inflammatory joint disease that disables millions of people worldwide. We show that TRPC5 and TRPC1 are expressed in secretory fibroblast-like synoviocytes from patients with rheumatoid arthritis, that endogenous TRPC5-TRPC1 channels of the cells are activated by reduced thioredoxin, and that blockade of the channels enhances secretory activity and prevents the suppression of secretion by thioredoxin. The data indicate the presence of a previously unrecognized ion-channel activation mechanism that couples extracellular thioredoxin to cell function.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645077/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645077/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, Shang-Zhong -- Sukumar, Piruthivi -- Zeng, Fanning -- Li, Jing -- Jairaman, Amit -- English, Anne -- Naylor, Jacqueline -- Ciurtin, Coziana -- Majeed, Yasser -- Milligan, Carol J -- Bahnasi, Yahya M -- Al-Shawaf, Eman -- Porter, Karen E -- Jiang, Lin-Hua -- Emery, Paul -- Sivaprasadarao, Asipu -- Beech, David J -- 077424/Wellcome Trust/United Kingdom -- 083857/Wellcome Trust/United Kingdom -- 18475/Arthritis Research UK/United Kingdom -- BB/D524875/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- England -- Nature. 2008 Jan 3;451(7174):69-72. doi: 10.1038/nature06414.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18172497" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arthritis, Rheumatoid/metabolism/pathology ; Cell Line ; Disulfides/chemistry/metabolism ; Electric Conductivity ; Humans ; Oxidation-Reduction/drug effects ; Patch-Clamp Techniques ; Rabbits ; TRPC Cation Channels/*agonists/chemistry/*metabolism ; Thioredoxins/chemistry/*pharmacology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 10
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    Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-03-30
    Description: Blood lymphocyte numbers, essential for the development of efficient immune responses, are maintained by recirculation through secondary lymphoid organs. We show that lymphocyte trafficking is altered by the lysophospholipid sphingosine-1-phosphate (S1P) and by a phosphoryl metabolite of the immunosuppressive agent FTY720. Both species were high-affinity agonists of at least four of the five S1P receptors. These agonists produce lymphopenia in blood and thoracic duct lymph by sequestration of lymphocytes in lymph nodes, but not spleen. S1P receptor agonists induced emptying of lymphoid sinuses by retention of lymphocytes on the abluminal side of sinus-lining endothelium and inhibition of egress into lymph. Inhibition of lymphocyte recirculation by activation of S1P receptors may result in therapeutically useful immunosuppression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mandala, Suzanne -- Hajdu, Richard -- Bergstrom, James -- Quackenbush, Elizabeth -- Xie, Jenny -- Milligan, James -- Thornton, Rosemary -- Shei, Gan-Ju -- Card, Deborah -- Keohane, CarolAnn -- Rosenbach, Mark -- Hale, Jeffrey -- Lynch, Christopher L -- Rupprecht, Kathleen -- Parsons, William -- Rosen, Hugh -- New York, N.Y. -- Science. 2002 Apr 12;296(5566):346-9. Epub 2002 Mar 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology and Rheumatology, Merck Research Laboratories, Post Office Box 2000, Rahway, NJ 07065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11923495" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/drug effects/*physiology ; Binding, Competitive ; CHO Cells ; Calcium/metabolism ; Cricetinae ; Cyclic AMP/metabolism ; Fingolimod Hydrochloride ; Guanosine 5'-O-(3-Thiotriphosphate)/metabolism ; Humans ; Immunosuppressive Agents/metabolism/pharmacology ; Ligands ; Lymph Nodes/cytology/drug effects ; Lymphocyte Count ; Lymphopenia/chemically induced ; *Lysophospholipids ; Mice ; Organophosphates/chemical synthesis/chemistry/metabolism/*pharmacology ; Organophosphonates/chemical synthesis/chemistry/metabolism/*pharmacology ; Phosphorylation ; Propylene Glycols/*metabolism/pharmacology ; Rats ; Receptors, Cell Surface/*agonists/metabolism ; *Receptors, G-Protein-Coupled ; Receptors, Lysophospholipid ; Sphingosine/*analogs & derivatives/metabolism/*pharmacology ; Spleen/cytology/drug effects ; Stereoisomerism ; T-Lymphocytes/drug effects/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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