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  • 1
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    ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-11-23
    Description: Recruitment of neutrophils to sites of inflammation is mediated in part by endothelial leukocyte adhesion molecule-1 (ELAM-1), which is expressed on activated endothelial cells of the blood vessel walls. ELAM-1 is a member of the LEC-CAM or selectin family of adhesion molecules that contain a lectin motif thought to recognize carbohydrate ligands. In this report, cell adhesion by ELAM-1 is shown to be mediated by a carbohydrate ligand, sialyl-Lewis X (SLex; NeuAc alpha 2,3Gal beta 1,4(Fuc alpha 1,3)-GlcNAc-), a terminal structure found on cell-surface glycoprotein and glycolipid carbohydrate groups of neutrophils.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Phillips, M L -- Nudelman, E -- Gaeta, F C -- Perez, M -- Singhal, A K -- Hakomori, S -- Paulson, J C -- New York, N.Y. -- Science. 1990 Nov 23;250(4984):1130-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cytel Corp., La Jolla, CA 92037.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1701274" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/pharmacology ; Antigens, CD15/chemistry/*physiology ; Carbohydrate Conformation ; Carbohydrate Sequence ; Cell Adhesion/*physiology ; Cell Adhesion Molecules/immunology/*physiology ; Cell Line ; Cricetinae ; E-Selectin ; Glycosylation ; Humans ; Ligands ; Molecular Sequence Data ; Neuraminidase/pharmacology ; Neutrophils/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A glycolipid antigen associated with Burkitt lymphoma defined by a monoclonal antibody (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-29
    Description: The antigen defined by a rat monoclonal antibody directed to a Burkitt lymphoma cell line was identified as globotriaosylceramide [Gal alpha (1 leads to 4)-Gal beta (1 leads to 4)-Glc beta (1 leads to 1)-ceramide]. The antibody demonstrated a strict steric specificity since it did not react with globoisotriaosylceramide [Gal alpha (1 leads to 3)-Gal beta (1 leads to 4)-Glc beta (1 leads to 1)-ceramide], the positional isomer of the antigen associated with the Burkitt lymphoma. Chemical analysis of various Burkitt lymphoma cell lines revealed that the Burkitt lymphoma cells contained more than 100 times as much of the glycolipid antigen as was found in other human lymphoma and leukemia cell lines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nudelman, E -- Kannagi, R -- Hakomori, S -- Parsons, M -- Lipinski, M -- Wiels, J -- Fellous, M -- Tursz, T -- CA 19224/CA/NCI NIH HHS/ -- CA 20026/CA/NCI NIH HHS/ -- GM 23100/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):509-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836295" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/*immunology ; Antigens, Neoplasm/*immunology ; Burkitt Lymphoma/*immunology ; Cell Line ; Cell Transformation, Neoplastic/metabolism ; Erythrocytes/immunology ; Globosides/*immunology ; Glycosphingolipids/*immunology ; Humans ; Rabbits ; Rats ; *Trihexosylceramides
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    KINETIC STUDY OF THE REACTIONS OF2-AMINO-5-CHLOROBENZOPHENONE WITH HCl in MeOH-H2O (1997)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 10 (1997), S. 97-106 
    Details
    ISSN: 0894-3230
    Keywords: 2-amino-5-chlorobenzophenone ; hydrochloric acid ; kinetics ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: ---The reaction of 2-amino-5-chlorobenzophenone (1) with 0·5-2 M HCl was studied in 1:1 (v/v) MeOH-H2O at 60 and 80 °C. Products that were isolated were characterized as 2-(N-methylamino-5-chlorobenzophenone) (2), 2- amino-3,5-dichlorobenzophenone (3), 2-N-methylamino-3,5-dichlorobenzophenone (4), 2-(N,N)-dimethylamino-5- chlorobenzophenone (5), 2,4-dichloro-10-methyl-9,10-acridinone (6) and 2,4-dichloro-9,10-acridinone (7). The rates of reaction of 1 and the rates of formation of 2-5 were measured at several HCl concentrations. The methyl transfers, the chlorination and the cyclization reactions that give rise to 2-7 were unexpected under the present reaction conditions. A set of differential equations was proposed in order to calculate the rate constants for each step of this complex reaction. The proposed reaction scheme also takes into account the reaction 2→1 and permits the calculation of the rate constants for this reversible reaction. The experimental values of the rate constants for reaction of 1 were compared with those for 2 under the same reaction conditions, in order to evaluate the importance of the methyl group on the methyl transfer reactions; it was found that the methyl group is not required for the unexpected reaction to occur. © 1997 by John Wiley & Sons, Ltd.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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