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  • Humans  (92)
  • Chemical Engineering  (88)
  • 1985-1989  (180)
  • 1985  (180)
  • 1
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    The neu gene: an erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-09-06
    Beschreibung: The neu oncogene, identified in ethylnitrosourea-induced rat neuroglioblastomas, had strong homology with the erbB gene that encodes the epidermal growth factor receptor. This homology was limited to the region of erbB encoding the tyrosine kinase domain. It was concluded that the neu gene is a distinct novel gene, as it is not coamplified with sequences encoding the EGF receptor in the genome of the A431 tumor line and it maps to human chromosome 17.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schechter, A L -- Hung, M C -- Vaidyanathan, L -- Weinberg, R A -- Yang-Feng, T L -- Francke, U -- Ullrich, A -- Coussens, L -- CA 39964-01/CA/NCI NIH HHS/ -- GM 26105/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1985 Sep 6;229(4717):976-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2992090" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antigens, Neoplasm/*genetics ; Chromosome Mapping ; Chromosomes, Human, 16-18 ; DNA, Neoplasm/*genetics ; Genes ; Genetic Linkage ; Humans ; Neoplasm Proteins/*genetics ; Neuroblastoma/genetics ; Neuroglia ; *Oncogenes ; Rats ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/*genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
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    Selective extraction of small and large molecules from the cerebrospinal fluid by Purkinje neurons (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-04-19
    Beschreibung: Cerebellar Purkinje neurons accumulated propidium iodide, granular blue, and horseradish peroxidase conjugated to wheat germ agglutinin but not unconjugated horseradish peroxidase, bisbenzimide, or Evans blue when these compounds were infused into the lateral cerebral ventricles of awake, unrestrained rats. Accumulation of propidium iodide by Purkinje neurons of the vermis was associated with a reproducible behavioral abnormality characterized by truncal tremor, ataxia, and nystagmus. Both the accumulation of propidium iodide in Purkinje cells and the behavioral abnormality were prevented by prior intracerebroventricular administration of ouabain or colchicine, drugs that block neuronal transport processes. The ability of cerebellar Purkinje neurons to extract small and large molecules from the cerebrospinal fluid has important implications for their physiology and pathology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Borges, L F -- Elliott, P J -- Gill, R -- Iversen, S D -- Iversen, L L -- New York, N.Y. -- Science. 1985 Apr 19;228(4697):346-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2580350" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Bisbenzimidazole/metabolism ; Cerebrospinal Fluid/*physiology ; Dendrites/physiology ; Evans Blue/metabolism ; Horseradish Peroxidase/metabolism ; Humans ; Male ; Propidium/metabolism/pharmacology ; Purkinje Cells/*metabolism/physiology ; Rats ; Rats, Inbred Strains ; Tremor/chemically induced/physiopathology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 3
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    Expression of Plasmodium falciparum circumsporozoite proteins in Escherichia coli for potential use in a human malaria vaccine (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-05-24
    Beschreibung: The circumsporozoite (CS) protein of the human malaria parasite Plasmodium falciparum may be the most promising target for the development of a malaria vaccine. In this study, proteins composed of 16, 32, or 48 tandem copies of a tetrapeptide repeating sequence found in the CS protein were efficiently expressed in the bacterium Escherichia coli. When injected into mice, these recombinant products resulted in the production of high titers of antibodies that reacted with the authentic CS protein on live sporozoites and blocked sporozoite invasion of human hepatoma cells in vitro. These CS protein derivatives are therefore candidates for a human malaria vaccine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Young, J F -- Hockmeyer, W T -- Gross, M -- Ballou, W R -- Wirtz, R A -- Trosper, J H -- Beaudoin, R L -- Hollingdale, M R -- Miller, L H -- Diggs, C L -- New York, N.Y. -- Science. 1985 May 24;228(4702):958-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2988125" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Antibody Formation ; Antigens, Surface/genetics/*immunology ; Carcinoma, Hepatocellular ; Cell Line ; Cloning, Molecular ; Cross Reactions ; DNA, Recombinant ; Escherichia coli/genetics ; Humans ; Liver Neoplasms ; Malaria/*prevention & control ; Mice ; Plasmodium/immunology ; Plasmodium falciparum/genetics/*immunology/physiology ; *Protozoan Proteins ; Vaccines/*immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-10-04
    Beschreibung: The T-cell tropic retrovirus of macaque monkeys STLV-III has morphologic, growth, and antigenic properties indicating that it is related to HTLV-III/LAV, the etiologic agent of the acquired immune deficiency syndrome (AIDS) in humans. Four of six rhesus monkeys died within 160 days of STLV-III inoculation with a wasting syndrome, opportunistic infections, a primary retroviral encephalitis, and immunologic abnormalities including a decrease in T4+ peripheral blood lymphocytes. These data show that an immunodeficiency syndrome can be produced experimentally in a nonhuman primate by an agent from the HTLV-III/LAV group of retroviruses. The STLV-III-macaque system will thus provide a useful model for the study of antiviral agents and vaccine development for human AIDS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Letvin, N L -- Daniel, M D -- Sehgal, P K -- Desrosiers, R C -- Hunt, R D -- Waldron, L M -- MacKey, J J -- Schmidt, D K -- Chalifoux, L V -- King, N W -- AI 20729/AI/NIAID NIH HHS/ -- CA 34979/CA/NCI NIH HHS/ -- CA 38205/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Oct 4;230(4721):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2412295" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*microbiology/pathology ; Animals ; Brain/pathology ; Deltaretrovirus ; *Disease Models, Animal ; Epitopes/analysis ; Humans ; Interleukin-2 ; Leukocyte Count ; Lymphocyte Activation ; Macaca mulatta ; Microscopy, Electron ; Pancreas/pathology ; *Retroviridae ; T-Lymphocytes/immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
    Digitale Medien
    Digitale Medien
    Turbulent flow in stirred tanks. Part I: Turbulent flow in the turbine impeller region (1985)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 31 (1985), S. 1113-1120 
    Details
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The concept of the trailing vortex introduced by van't Riet and Smith (1975) is used for evaluation of the mean velocity and intensity of periodic velocity fluctuations in the turbine impeller discharge flow. From the analysis of forces acting on the trailing vortex, it follows that geometric similarity in the impeller discharge flow can be expected for the Reynolds number range Re ε 〈1.5 × 104; 9.0 × 104〉 and for the radial distance up to one-tenth of the impeller diameter. The calculated profiles of mean velocity and intensity of periodic velocity fluctuations agree with published data and permit the declaration of boundary conditions for the impeller discharge flow for numerical modeling of turbulent fluid flow in turbine impeller agitated tanks.
    Zusätzliches Material: 12 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aic.690310709
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  • 6
    Digitale Medien
    Digitale Medien
    Hydrodeoxygenation of 1-naphthol catalyzed by sulfided Ni-Mo/γ-Al2O3: Reaction network (1985)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 31 (1985), S. 170-174 
    Details
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aic.690310125
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  • 7
    Digitale Medien
    Digitale Medien
    Mass transfer in a liquid-liquid CFSTR (1985)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 31 (1985), S. 659-666 
    Details
    ISSN: 0001-1541
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The performance of a two-phase liquid-liquid continuous flow stirred tank reactor (CFSTR) was evaluated experimentally by simultaneous determination of dispersed phase drop size distribution and extraction efficienty as a function of reactor operating conditions. The results provided a basis against which predictions made by a previously developed simulation technique (Bapat et al., 1984) were compared. The close agreement between the experimental and the simulation results validates the drop rate models and the simulation algorithm employed in this work.
    Zusätzliches Material: 7 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aic.690310416
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  • 8
    Digitale Medien
    Digitale Medien
    Surface embrittlement of ductile polymers: A fracture mechanics analysis (1985)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 25 (1985), S. 207-211 
    Details
    ISSN: 0032-3888
    Schlagwort(e): Chemistry ; Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: The embrittlement of ductile polymers resulting from outdoor weathering or aging or from the application of brittle surface coatings is explained using fracture mechanics principles. It is shown that in order for surface embrittlement to occur, the brittle surface should have a dynamic stress intensity factor at the brittle/ductile interface that exceeds the arrest toughness of the ductile polymer. This phenomenon is modeled using duplex tensile specimens fabricated from poly(methylmethacrylate) (brittle layer) and polycarbonate (ductile substrate) as well as from styrene-acrylonitrile and acrylonitrile-butadiene-styrene copolymers.
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/pen.760250404
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  • 9
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    Immunogenicity of synthetic peptides from circumsporozoite protein of Plasmodium falciparum (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-05-24
    Beschreibung: In a study of recombinant proteins that might be useful in developing a vaccine against malaria, synthetic peptides from the circumsporozoite (CS) protein of Plasmodium falciparum were found to be immunogenic for mice and rabbits. Antibody to peptides from the repeating region of the CS protein recognized native CS protein and blocked sporozoite invasion of human hepatoma cells in vitro. Antibodies to peptides from regions I and II had no biologic activity, although antibody to region I recognized processed CS protein by Western blot analysis. These data support the feasibility of developing a vaccine against the sporozoite stage of the malaria parasite by using synthetic peptides of the repeating region of the CS protein conjugated to a carrier protein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ballou, W R -- Rothbard, J -- Wirtz, R A -- Gordon, D M -- Williams, J S -- Gore, R W -- Schneider, I -- Hollingdale, M R -- Beaudoin, R L -- Maloy, W L -- New York, N.Y. -- Science. 1985 May 24;228(4702):996-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2988126" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Antibodies/immunology ; Antibody Formation ; Antigens, Surface/*immunology ; Carcinoma, Hepatocellular ; Cell Line ; Cross Reactions ; Fluorescent Antibody Technique ; Humans ; Immune Sera/immunology ; Liver Neoplasms ; Malaria/prevention & control ; Mice ; Peptides/chemical synthesis/*immunology ; Plasmodium/immunology ; Plasmodium falciparum/*immunology/physiology ; Precipitin Tests ; *Protozoan Proteins ; Rabbits ; Vaccines/immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    Genotoxicity of formaldehyde in cultured human bronchial fibroblasts (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1985-04-05
    Beschreibung: Formaldehyde, a common environmental pollutant, inhibits repair of O6-methylguanine and potentiates the mutagenicity of an alkylating agent, N-methyl-N-nitrosourea, in normal human fibroblasts. Because formaldehyde alone also causes mutations in human cells, the compound may cause genotoxicity by a dual mechanism of directly damaging DNA and inhibiting repair of mutagenic and carcinogenic DNA lesions caused by other chemical and physical carcinogens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grafstrom, R C -- Curren, R D -- Yang, L L -- Harris, C C -- New York, N.Y. -- Science. 1985 Apr 5;228(4695):89-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3975633" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Bronchi/cytology ; Cells, Cultured ; DNA Repair/*drug effects ; Drug Synergism ; Fibroblasts/drug effects ; Formaldehyde/*adverse effects/pharmacology ; Guanine/analogs & derivatives/metabolism ; Humans ; Methylnitrosourea/pharmacology ; Mutagens/*pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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