ISSN:
1434-4475
Keywords:
Gastro-intestinal hormones
;
Human-Big-Gastrin
;
Peptide synthesis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Human-Big-Gastrin I, a peptide hormone of 34 amino acid residues, and the 32-leucine analogue were synthesized. For this purpose six suitable peptide fragments were prepared at first, which subsequently were condensed to the total sequence. In this paper we describe the syntheses of four suitably protected peptide fragments corresponding to the sequences 28–34, 23–27, 21–22 and 15–20 of human-big-gastrin I. For the protection of the side-chain functionstert-butanol derived groups removable in the final step by acidolytic cleavage were used. The α-amino-functions were selectively blocked as benzyloxycarbonyl-and 2-nitrophenylsulfenyl-derivatives, respectively.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00938288
Permalink