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  • 1
    Electronic Resource
    Electronic Resource
    Effects of isoproterenol on the dense core and perigranular membrane of atrial specific granules (1979)
    Springer
    Cell & tissue research 199 (1979), S. 213-224 
    Details
    ISSN: 1432-0878
    Keywords: Atrial myocardium ; Ultrahistochemistry ; Membrane permeability ; Horseradish peroxidase ; Glandular release
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Following subcutaneous injections of isoproterenol hydrochloride (ISO), atrial cells present a large number of partly degranulated or completely clear “specific granules” enclosed by an intact membrane. Such profiles were never encountered in normal controls and might suggest ISO-induced release of a secretory product. Permeability of perigranular membrane was tested using the extracellular macromolecular tracer horseradish peroxidase (HRP). Reaction product was entirely absent within granules of atrial cells in which the sarcolemma was made permeable to HRP molecules by the ISO injections. This seemed to be the case even in heavily labelled cells in which the peroxidase had penetrated the mitochondrial membranes. In atrial cells impermeable to the tracer, the specific granules closely apposed to the sarcolemma were always HRP-negative. The release mechanism of a possible secretory substance from the specific granules is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236133
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  • 2
    Electronic Resource
    Electronic Resource
    The T-tubule system in the myocardia of the sand rat and mouse as demonstrated by horseradish peroxidase (1978)
    Springer
    Cell & tissue research 192 (1978), S. 205-213 
    Details
    ISSN: 1432-0878
    Keywords: Myocardium ; T-tubule system ; Horseradish peroxidase ; Sand rat ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The transverse tubule (T-tubule) system in papillary muscles of the sand rat and the mouse were studied with the aid of a diffusion tracer (horseradish peroxidase). The T-tubule system in the sand rat showed a typical mammalian pattern with sarcolemmal tubules invaginating at the Z-band level of the sarcomere. These tubules follow a transverse direction in the cell with frequent longitudinal side-branches which connect tubules at different Z-band levels. In the mouse myocardium, the T-tubules also start as lateral invaginations from the sarcolemma at the Z-band levels. In the cell interior, however, the tubules ramify and brake up into a complicated system of spirally running tubules. These spirals, of relative small diameter (400Å–700Å), frequently expand and form lobulated cisternae at the Z-band levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220739
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    Paper (German National Licenses)
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