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  • 1
    Electronic Resource
    Electronic Resource
    Histogenesis of the semilunar valves: an immunohistochemical analysis of tenascin and type-I collagen distribution in developing chick heart valves (1990)
    Springer
    Cell & tissue research 259 (1990), S. 299-304 
    Details
    ISSN: 1432-0878
    Keywords: Semilunar valves ; Extracellular matrix ; Tenascin ; Type-I collagen ; Heart morphogenesis ; Domestic fowl
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The development of the semilunar valves takes place in association with septation of the outflow tract in the embryonic heart. Although numerous studies have focused on this process, the causal mechanisms of valvular development remain obscure. This paper reports an immunohistochemical analysis of tenascin and type-I collagen distribution in developing chick heart valves. Tenascin is a glycoprotein that is present on some embryonic extracellular matrices. It plays several significant roles in tissue differentiation, cell growth, and tissue interactions; it is also important for the formation of specific zones of connective tissue that fulfill mechanical functions. Our results show that tenascin is present during valvular morphogenesis and histogenesis, and that its distribution is associated with zones specialized in bearing mechanical loads.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318452
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of colchicine administration on the endothelial cells of the developing semilunar heart valves of the chick embryo (1987)
    Springer
    Cell & tissue research 250 (1987), S. 595-598 
    Details
    ISSN: 1432-0878
    Keywords: Endothelial cells ; Heart morphogenesis ; Semilunar valves ; Colchicine ; Chick embryo
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Recent ultrastructural studies have revealed that differences exist in endothelial cell shape and cytoskeletal architecture between the arterial and ventricular faces of developing semilunar valves. In the present work we analyzed the morphologic response of the valvular endothelial cells of chick embryos to colchicine by light microscopy, scanning electron microscopy and transmission electron microscopy. The results show that colchicine administration during the stages of valve morphogenesis causes a very conspicuous disruption of the endothelial layer of the arterial face of the valves. The cells appear rounded and show massive surface blebbing. These alterations were not present in the endothelial cells on the ventricular face of the valves at the same stages. On the basis of these results we suggest that a difference in the degree of cell differentiation exists between the endothelial cells of the arterial and ventricular faces of the cusps and that this difference may have morphogenetic significance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218952
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    Paper (German National Licenses)
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