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  • 1
    Publication Date: 2013-04-05
    Description: FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential Cell Death and Disease 4, e578 (April 2013). doi:10.1038/cddis.2013.109 Authors: S Romano, S Staibano, A Greco, A Brunetti, G Nappo, G Ilardi, R Martinelli, A Sorrentino, A Di Pace, M Mascolo, R Bisogni, M Scalvenzi, B Alfano & M F Romano
    Keywords: melanomametastasiscancer stem cellepithelial to mesenchymal transitionFKBP51
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 2
    Publication Date: 2020-10-22
    Description: We applied the method for Probabilistic Tsunami Hazard Analysis (PTHA), first introduced by Rikitake and Aida (1988), to the coasts of eastern Sicily (Italy), and focusing on important cities such as Messina, Catania, and Augusta. The method has been very recently improved by Gonzàlez et al. (2009) to explicitly include inundation. Our approach considers both far- and near-field sources. Based on the approach described by Lorito et al. (2008), we identified a few Source Zones (SZ), each of which is characterized by a Typical Fault (TF) floating within it and capable of generating the Maximum Credible Earthquake (MCE). Some of the MCE recall historical events such as the 1908 Messina, the 1693 Catania and the 365 AD Crete earthquakes. We calculated the combined probability for all considered SZs by assigning a recurrence interval to each of them and a Poisson distribution of the inter-event times. We performed the PTHA for different damage metrics, such as runup, current speed, momentum and Froude number, with probability of exceedance of given thresholds being evaluated for different time intervals.
    Description: Published
    Description: San Francisco
    Description: 4.2. TTC - Modelli per la stima della pericolosità sismica a scala nazionale
    Description: open
    Keywords: Tsunami ; Hazard ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: Conference paper
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  • 3
    Publication Date: 2017-04-04
    Description: Probabilistic tsunami hazard analysis (PTHA) relies on computationally demanding numerical simulations of tsunami generation, propagation, and non-linear inundation on high-resolution topo-bathymetric models. Here we focus on tsunamis generated by co-seismic sea floor dis- placement, that is, on Seismic PTHA (SPTHA). A very large number of tsunami simulations are typically needed to incorporate in SPTHA the full expected variability of seismic sources (the aleatory uncertainty). We propose an approach for reducing their number. To this end, we (i) introduce a simplified event tree to achieve an effective and consistent exploration of the seismic source parameter space; (ii) use the computationally inexpensive linear approximation for tsunami propagation to construct a preliminary SPTHA that calculates the probability of maximum offshore tsunami wave height (H Max) at a given target site; (iii) apply a two-stage filtering procedure to these ‘linear’ SPTHA results, for selecting a reduced set of sources and (iv) calculate ‘non-linear’ probabilistic inundation maps at the target site, using only the selected sources. We find that the selection of the important sources needed for approximating probabilistic inundation maps can be obtained based on the offshore HMax values only. The filtering procedure is semi-automatic and can be easily repeated for any target sites. We describe and test the performances of our approach with a case study in the Mediterranean that considers potential subduction earthquakes on a section of the Hellenic Arc, three target sites on the coast of eastern Sicily and one site on the coast of southern Crete. The comparison between the filtered SPTHA results and those obtained for the full set of sources indicates that our approach allows for a 75–80 per cent reduction of the number of the numerical simulations needed, while preserving the accuracy of probabilistic inundation maps to a reasonable degree.
    Description: Published
    Description: 574-588
    Description: 3T. Pericolosità sismica e contributo alla definizione del rischio
    Description: JCR Journal
    Description: restricted
    Keywords: Tsunami ; Hazard ; Probabilistic ; Subduction ; Mediterranean ; SPTHA ; 04. Solid Earth::04.06. Seismology::04.06.02. Earthquake interactions and probability ; 04. Solid Earth::04.07. Tectonophysics::04.07.04. Plate boundaries, motion, and tectonics ; 04. Solid Earth::04.07. Tectonophysics::04.07.06. Subduction related processes
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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