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  • 1
    Electronic Resource
    Electronic Resource
    Clearance of ceftriaxone during haemodialysis using cuprophane, haemophane and polysulfone dialysers (1997)
    Springer
    European journal of clinical pharmacology 53 (1997), S. 123-126 
    Details
    ISSN: 1432-1041
    Keywords: Key wordsCeftriaxone ; Haemodialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The purpose of the present study was to investigate whether the clearance of ceftriaxone during haemodialysis is influenced by the type of membrane used (cuprophane, haemophane or polysulphone). Methods: After administration of a single 2-g dose of ceftriaxone, the half-life of the drug during haemodialysis and the clearance of the dialyser were measured. Results: The mean dialysis clearance normalised for square metre of membrane surface was significantly different for the three dialysers (haemophane 24  ml · min−1 · m−2; cuprophane 32 ml · min−1 · m−2; polysul phone 42 ml · min−1· m−2). Conclusions: Polysulphone membranes are more permeable and increase the extraction of ceftriaxone more than the other dialysers studied (haemophane and cuprophane membranes). These results, taken together with previous data, show that an increase of the dose in dialysis patients treated with large surface (〉0.8 m2) and high permeability membranes might be necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050349
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and dialysability of isradipine in chronic haemodialysis patients (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 231-233 
    Details
    ISSN: 1432-1041
    Keywords: Isradipine ; Haemodialysis ; pharmacokinetics ; dialysability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of isradipine, a calcium-channel blocker, have been studied in eight patients on chronic haemodialysis. A single oral dose of 5 mg was administered on both a non-haemodialysis and a haemodialysis day and the plasma concentrations of isradipine were analyzed. The mean cmax, tmax, AUC, and t1/2 in plasma on the non-haemodialysis day were 5.2 ng·ml−1, 1.4 h, 23.8 ng·h·ml−1, and 3.1 h, respectively. The dialysis clearance of isradipine was negligible (5.0 ml·min−1). The t1/2 values during haemodialysis were not significantly different from those observed during the same period post dose on the non-haemodialysis day. The study demonstrates that supplemental doses of isradipine are not necessary in these patients since isradipine is not significantly removed by haemodialysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00278492
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    Paper (German National Licenses)
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