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  • HIV pharmacology  (1)
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    Electronic Resource
    Electronic Resource
    The HIV gp120-CD4 interaction: A target for pharmacological or immunological intervention? (1993)
    Springer
    Perspectives in drug discovery and design 1 (1993), S. 235-250 
    Details
    ISSN: 1573-9023
    Keywords: HIV ; gp120 ; CD4 ; gp120-CD4 interaction ; Anti-gp120 antibodies ; HIV pharmacology ; HIV therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The gp120-CD4 interaction is the initial stage in the infection cycle of CD4+ cells by HIV. It is therefore a logical target for pharmacological or immunological intervention. We review what is known about the gp120-CD4 binding reaction and the structures of the interacting ligands. We then discuss previous attempts to inhibit this interaction using antibodies and drugs, assess why such attempts have failed so far in vivo, and suggest future strategems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02171665
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