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  • H-2 Antigens/immunology  (2)
  • Mice, Transgenic  (2)
  • 1
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    Immunology. Hide and seek in the peptidome (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-09-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yewdell, Jonathan W -- New York, N.Y. -- Science. 2003 Sep 5;301(5638):1334-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0440, USA. jyewdell@nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12958347" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antigen Presentation ; CD8-Positive T-Lymphocytes/immunology ; Codon ; Cysteine Endopeptidases/metabolism ; Epstein-Barr Virus Nuclear Antigens/chemistry/*genetics/*immunology/metabolism ; Herpesvirus 4, Human/physiology ; Histocompatibility Antigens Class I/*immunology ; Humans ; Mice ; Mice, Transgenic ; Multienzyme Complexes/metabolism ; Peptides/genetics/*immunology/*metabolism ; Proteasome Endopeptidase Complex ; *Protein Biosynthesis ; Reading Frames ; Ribosomes/metabolism ; Self Tolerance ; Virus Latency
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Brefeldin A specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1989-06-02
    Beschreibung: Cytotoxic T lymphocytes (CTLs) recognize foreign antigens, including viral proteins, in association with major histocompatibility complex (MHC) class I molecules. Brefeldin A, a specific inhibitor of exocytosis, completely and reversibly inhibited the presentation of viral proteins, but not exogenous peptides, to MHC class I-restricted CTLs directed against influenza virus antigens. The effect of brefeldin A on antigen presentation correlated with its inhibition of intracellular transport of newly synthesized class I molecules. Brefeldin A is thus a specific inhibitor of antigen processing for class I-restricted T cell recognition. Its effect on antigen presentation supports the idea that exogenous peptide antigens associate with cell surface class I molecules, whereas protein antigens processed via the cytosolic route associate with nascent class I molecules before they leave the trans-Golgi complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yewdell, J W -- Bennink, J R -- New York, N.Y. -- Science. 1989 Jun 2;244(4908):1072-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Viral Diseases, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2471266" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antigen-Presenting Cells/*drug effects/immunology ; Antigens, Viral/*immunology ; Biological Transport/drug effects ; Brefeldin A ; Cell Membrane/immunology ; Cyclopentanes/*pharmacology ; Endoplasmic Reticulum/immunology ; Epitopes/immunology ; Exocytosis/drug effects ; Golgi Apparatus/immunology ; H-2 Antigens/immunology ; Hemagglutinins/genetics/immunology ; Histocompatibility Antigens Class I/immunology ; Mice ; Nucleoproteins/immunology ; Orthomyxoviridae/immunology ; T-Lymphocytes, Cytotoxic/drug effects/*immunology ; Transfection ; Viral Proteins/*immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Antigen presentation requires transport of MHC class I molecules from the endoplasmic reticulum (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1990-02-09
    Beschreibung: The role of exocytosis of major histocompatibility complex (MHC) class I molecules in the presentation of antigens to mouse cytotoxic T lymphocytes (CTLs) was examined by use of a recombinant vaccinia virus that expresses the E19 glycoprotein from adenovirus. E19 blocked the presentation of vaccinia and influenza virus proteins to CTLs in a MHC class I allele-specific manner identical to its inhibition of MHC class I transport from the endoplasmic reticulum. This finding indicates that (i) the relevant parameter for antigen presentation is the rate of MHC class I molecule exocytosis, not the level of class I cell surface expression, and (ii) association of class I molecules with antigen is likely to occur within the endoplasmic reticulum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cox, J H -- Yewdell, J W -- Eisenlohr, L C -- Johnson, P R -- Bennink, J R -- New York, N.Y. -- Science. 1990 Feb 9;247(4943):715-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2137259" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenovirus Early Proteins ; Animals ; Antigen-Presenting Cells/drug effects/immunology/*ultrastructure ; Antigens/*immunology ; Antigens, Viral/immunology ; Antiviral Agents ; Biological Transport ; Brefeldin A ; Cell Line ; Cyclopentanes/pharmacology ; Endoplasmic Reticulum/*immunology ; Exocytosis ; Glycoproteins/analysis ; H-2 Antigens/immunology ; Histocompatibility Antigens Class I/immunology/*metabolism ; Mice ; Mice, Inbred A ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Mice, Inbred CBA ; Oncogene Proteins, Viral/analysis ; Orthomyxoviridae Infections/immunology ; Recombinant Proteins/immunology ; T-Lymphocytes, Cytotoxic/*immunology ; Vaccinia virus/immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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    AKTUELLE ARTIKEL
  • 4
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    CD8+ T cell cross-priming via transfer of proteasome substrates (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2004-05-29
    Beschreibung: "Cross-priming" describes the activation of naive CD8+ T cells by professional antigen-presenting cells that have acquired viral or tumor antigens from "donor" cells. Antigen transfer is believed to be mediated by donor cell-derived molecular chaperones bearing short peptide ligands generated by proteasome degradation of protein antigens. We show here that cross-priming is based on the transfer of proteasome substrates rather than peptides. These findings are potentially important for the rational design of vaccines that elicit CD8+ T cell responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norbury, Christopher C -- Basta, Sameh -- Donohue, Keri B -- Tscharke, David C -- Princiotta, Michael F -- Berglund, Peter -- Gibbs, James -- Bennink, Jack R -- Yewdell, Jonathan W -- AI-056094-01/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2004 May 28;304(5675):1318-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892-0440, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15166379" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acetylcysteine/*analogs & derivatives/pharmacology ; Animals ; *Antigen Presentation ; Antigens/*immunology/metabolism ; Antigens, Viral/immunology/metabolism ; CD8-Positive T-Lymphocytes/*immunology ; Cell Line ; *Cross-Priming ; Cysteine Endopeptidases/*metabolism ; Cysteine Proteinase Inhibitors/pharmacology ; Endoplasmic Reticulum/metabolism ; Humans ; Immunization ; Influenza A virus/immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Molecular Chaperones/metabolism ; Multienzyme Complexes/*metabolism ; Ovalbumin/immunology/metabolism ; Peptide Fragments/immunology ; Proteasome Endopeptidase Complex ; Recombinant Fusion Proteins/immunology/metabolism ; Vaccines/immunology ; Vaccinia virus/genetics/physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
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