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  • 1
    Electronic Resource
    Electronic Resource
    Unique genomic sequences in human chromosome 16p are conserved in the great apes (1997)
    Springer
    Molecular genetics and genomics 253 (1997), S. 512-514 
    Details
    ISSN: 1617-4623
    Keywords: Key words Human chromosome 16 ; Chimpanzee ; Gorilla ; Orangutan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In humans, acute myelomonocytic leukemia (AMML) with abnormal bone marrow eosinophilia is diagnosed by the presence of a pericentric inversion in chromosome 16, involving breakpoints p13;q23 [i.e., inv(16)(p13;q23)]. A pericentric inversion involves breaks that have occurred on the p and q arms and the segment in between is rotated 180° and reattaches. The recent development of a “human micro-coatasome” painting probe for 16p contains unique DNA sequences that fluorescently label only the short arm of chromosome 16, which facilitates the identification of such inversions and represents an ideal tool for analyzing the “divergence/convergence” of the equivalent human chromosome 16 (PTR 18, GGO 17 and PPY 19) in the great apes, chimpanzee, gorilla and orangutan. When the probe is used on the type of pericentric inversion characteristic of AMML, signals are observed on the proximal portions (the regions closest to the centromere) of the long and short arms of chromosome 16. The probe hybridized to only the short arm of all three ape chromosomes and signals were not observed on the long arms, suggesting that a pericentric inversion similar to that seen in AMML has not occurred in any of these great apes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380050351
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  • 2
    Electronic Resource
    Electronic Resource
    Molecular phylogenetics of the hominoid Y chromosome (1998)
    Springer
    Journal of human genetics 43 (1998), S. 185-186 
    Details
    ISSN: 1435-232X
    Keywords: Key words Chimpanzee ; Gorilla ; Orangutan ; Human Y-chromosome ; Amelogenin gene ; Telomeric sequences ; Evolution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The Human Y-chromosome plays a central role in sex determination, and is composed of DNA sequences homologous to the Y-chromosome, families of Y-specific repetitive DNA sequences, and single copy sequences. We investigated the chromosomal location of Y-specific DNA sequences, in the chimpanzee (Pan troglodytes), gorilla (Gorilla gorilla), and orangutan (Pongo pygmaeus) by the fluorescence in situ hybridization (FISH) technique. The Yq subtelomeric DNA sequences (DYS427) have been observed to be intact at the presumed loci. Also, the amelogenin gene (AMELY, Yp11.2) revealed sequence homology and positional conservation in the higher primates, except in gorilla where positional divergence was observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380050066
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  • 3
    Electronic Resource
    Electronic Resource
    Localization of human midisatellite and macrosatellite DNA sequences on chromosomes 1 and X in the great apes (1999)
    Springer
    Journal of human genetics 44 (1999), S. 57-59 
    Details
    ISSN: 1435-232X
    Keywords: Key words Chimpanzee ; Gorilla ; Orangutan ; Chromosomes 1 and X ; Midisatellite and macrosatellite DNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The mechanism of speciation has remained largely unresolved, and hominoid evolutionary history based on chromosome rearrangements has been continuously challenged. The recent availability of the human-derived chromosome 1-specific midisatellite (D1Z2) and chromosome X-specific macrosatellite (DXZ4) DNA sequence probes has prompted us to hybridize the aforementioned to the members of the hominoid clade (chimpanzee, gorilla, and orangutan), using the fluorescence in-situ hybridization technique. Inconsistencies in the hybridization pattern for the D1Z2 DNA probe in the great ape species suggests that changes in this sequence have apparently taken place during the evolutionary process. No hybridization signal was observed in the orangutan chromosome 1, suggesting that a homologous D1Z2 DNA sequence may not be present in its genome, or that the sequence may be altered, rendering itself undetectable by human-derived DNA probes. Homology in the hybridization patterns for the DXZ4 probe in all three ape species illustrates that the sequence is apparently conserved. Such hybridization data provide some level of phylogenetic information on the recent ancestry of higher primates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380050108
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