Publication Date:
2002-07-06
Description:
Recent advances in the realization of individual molecular-scale electronic devices emphasize the need for novel tools and concepts capable of assembling such devices into large-scale functional circuits. We demonstrated sequence-specific molecular lithography on substrate DNA molecules by harnessing homologous recombination by RecA protein. In a sequence-specific manner, we patterned the coating of DNA with metal, localized labeled molecular objects and grew metal islands on specific sites along the DNA substrate, and generated molecularly accurate stable DNA junctions for patterning the DNA substrate connectivity. In our molecular lithography, the information encoded in the DNA molecules replaces the masks used in conventional microelectronics, and the RecA protein serves as the resist. The molecular lithography works with high resolution over a broad range of length scales from nanometers to many micrometers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keren, Kinneret -- Krueger, Michael -- Gilad, Rachel -- Ben-Yoseph, Gdalyahu -- Sivan, Uri -- Braun, Erez -- New York, N.Y. -- Science. 2002 Jul 5;297(5578):72-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, Solid State Institute, Technion-Israel Institute of Technology, Haifa 32000, Israel.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12098693" target="_blank"〉PubMed〈/a〉
Keywords:
Antibodies
;
Biopolymers
;
Biotin
;
DNA/chemistry/genetics/*metabolism
;
DNA, Single-Stranded/*metabolism
;
Electric Conductivity
;
*Electronics
;
Glutaral
;
Gold
;
Microscopy, Atomic Force
;
Microscopy, Electron, Scanning
;
*Nanotechnology
;
Nucleic Acid Hybridization
;
Rec A Recombinases/chemistry/immunology/*metabolism
;
Recombination, Genetic
;
Silver
;
Streptavidin
;
Templates, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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