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Synthese eines mit D-Glucuronsäure konjugierten Metaboliten von Ciamexon (1989)

Schultz, Michael ; Zörkler, Günter

Weinheim : Wiley-Blackwell

Liebigs Annalen 1989 (1989), S. 393-395

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ISSN: 0170-2041

Keywords: Glucuronidation ; Invertomers ; Esterase ; Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Synthesis of a Metabolite of Ciamexon Conjugated with D-Glucuronic AcidReaction of the alcohol 2 with the glucuronic acid derivative 6 in the presence of Ag triflate yields the protected β-D-glucuronide 8 by rearrangement of the orthoester 7. After deacetylation and saponification with pig liver esterase, the deblocked glucuronide 3 can be isolated. Due to the aziridine ring the glucuronic acid derivatives of 2 consist of a mixture of invertomers, as shown by 1H-NMR spectroscopy.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/jlac.198919890168

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