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  • 1
    Keywords: Sedimentology. ; Geomorphology. ; Geochemistry. ; Paleontology . ; Paleoecology. ; Environment. ; Sedimentology. ; Geomorphology. ; Geochemistry. ; Paleontology. ; Paleoecology. ; Environmental Sciences.
    Description / Table of Contents: Part1. Introduction -- Chapter1. Introduction to limnogeology: progress, challenges, and opportunities—A tribute to Elizabeth Gierlowski Kordesch -- Part2. African Lake -- Chapter2. Modern and ancient animal traces in the extreme environments of Lake Magadi and Nasikie Engida, Kenya rift valley -- Part3. European lakes -- Chapter3. Lake level fluctuations and allochthonous lignite deposition in the Eocene pull-apart basin “Prinz von Hessen” (Hesse, Germany) - A palynological study -- Chapter4. How changes of past vegetation and human impact are documented in lake sediments: Paleoenvironmental research in Southwestern Germany, a review -- Chapter5. Large-scale slumps and associated resedimented deposits in Miocene lake basins from SE Spain -- Chapter6. Lacustrine and fluvial microbialites in the Neogene of the Ebro Basin, Spain: a summary of up to date knowledge -- Part4. North America -- Chapter7. Ecological response of ostracodes (Arthropoda, Crustacea) to lake level fluctuations in the Eocene Green River Formation, Fossil Basin, Wyoming, USA -- Chapter8. History of Great Salt Lake, Utah, USA, since the termination of Lake Bonneville -- Chapter9. What’s new about the old Bonneville Basin? Fresh insights about the modern Limnogeology of Great Salt Lake -- Chapter10. Middle Holocene hydrologic changes catalyzed by river avulsion in Big Soda Lake, Nevada, USA -- Chapter11. Diatom record of Holocene moisture variability in the San Bernardino Mountains, California, USA -- Chapter12. A 12,000 year diatom-based palaeoenvironmental record from Lago de Zirahuén, Mexico -- Chapter13. Sedimentary record of the Zacapu Basin, Michoacán, México and implications for P’urhépecha Culture during the Pre-Classic and Post-Classic Periods -- Chapter14. Stratigraphy and Sedimentology of the Upper Pleistocene to Holocene Lake Chalco drill cores (Mexico Basin) -- Chapter15. Submarine groundwater discharge as a catalyst for eodiagenetic carbonate cements within marine sedimentary basins -- Part5. South America -- Chapter16. Reconstructing paleoenvironmental conditions through integration of paleogeography, stratigraphy, sedimentology, mineralogy, and stable isotope data of lacustrine carbonates—an example from early Middle Triassic strata of southwest Gondwana, Cuyana Rift, Argentina -- Part6. Asia -- Chapter17. Modern sedimentary systems of Qinghai Lake -- Chapter18. Freshwater microbialites in Early Jurassic fluvial strata of the Pranhita-Godavari Gondwana Basin, India.
    Abstract: This book honors the career of Professor Elizabeth Gierlowski-Kordesch who was a pioneer and leader in the field of limnogeology since the 1980s. Her work was instrumental in guiding students and professionals in the field until her untimely death in 2016. This collection of chapters was written by her colleagues and students and recognize the important role that Professor Gierlowski-Kordesch had in advancing the field of limnogeology. The chapters show the breadth of her reach as these have been contributed from virtually every continent. This book will be a primary reference for scientists, professionals and graduate students who are interested in the latest advances in limnogeologic processes and basin descriptions in North and South America, Europe, Africa, and China. *Free supplementary material available online for chapters 3,11,12 and 13. Access by searching for the book on link.springer.com.
    Type of Medium: Online Resource
    Pages: XV, 592 p. 230 illus., 196 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030665760
    Series Statement: Syntheses in Limnogeology,
    DDC: 551.3
    Language: English
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  • 2
    ISSN: 1573-5001
    Keywords: FKBP12 ; NMR detection ; sensitivity enhancement ; side chain–side chain hydrogen bonds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract We describe the direct observation of side chain–side chain hydrogen bonding interactions in proteins with sensitivity-enhanced NMR spectroscopy. Specifically, the remote correlation between the guanidinium nitrogen 15Nε of arginine 71, which serves as the hydrogen donor, and the acceptor carboxylate carbon 13CO2 γ of aspartate 100 in a 12 kDa protein, human FKBP12, is detected via the trans-hydrogen bond 3h J Nε CO2γ coupling by employing a novel HNCO-type experiment, soft CPD-HNCO. The 3h J Nε CO2γ coupling constant appears to be even smaller than the average value of backbone 3h J NC′ couplings, consistent with more extensive local dynamics in protein side chains. The identification of trans-hydrogen bond J-couplings between protein side chains should provide useful markers for monitoring hydrogen bonding interactions that contribute to the stability of protein folds, to alignments within enzyme active sites and to recognition events at macromolecular interfaces.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-5001
    Keywords: FKBP12 ; NMR detection ; sensitivity enhancement ; side chain–main chain hydrogen bonds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract We describe the direct observation of very weak side chain–main chain hydrogen bonding interactions in medium-size 13C/15N-labeled proteins with sensitivity-enhanced NMR spectroscopy. Specifically, the remote correlation between the hydrogen acceptor side chain carboxylate carbon 13CO2 δ of glutamate 54 and the hydrogen donor backbone amide 15N of methionine 49 in a 12 kDa protein, human FKBP12, is detected via the trans-hydrogen bond 3h J NCO2δ coupling by employing a novel sensitivity-enhanced HNCO-type experiment, CPD-HNCO. The 3h J NCO2δ coupling constant appears to be even smaller than the average value of backbone 3h J NC′ couplings, consistent with more extensive local dynamics in protein side chains.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 31 (1992), S. 384-400 
    ISSN: 0570-0833
    Keywords: Natural products ; Immunophilins ; Signal transduction ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: One of the great mysteries of cell biology remains the mechanism of information transfer, or signaling, through the cytoplasm of the cell. Natural products that inhibit this process offer a unique window into fundamental aspects of cytoplasmic signal transduction, the means by which extracellular molecules influence intracellular events. Thus, natural products chemistry, including organic synthesis, conformational analysis, and methods of structure elucidation, is a powerful tool in the study of cell function. This article traces our understanding of a group of natural products from the finding that they inhibit cytoplasmic signaling to their current recognition as mediators of the interaction between widely distributed protein targets. The emphasis of the discussion is primarily structural. The interactions between the natural-product ligands and their protein receptors are analyzed at a molecular level in order to shed light on the molecular mechanisms of the biological functions of these compounds. In the process we hope to illustrate the power of chemical analysis as applied to biological systems. Through chemistry we can understand the molecular basis of biological phenomena.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
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