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  • Animals  (13)
  • General Relativity and Gravitation
  • Electronic structure and strongly correlated systems
  • 1
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    Towards the Cardy formula for hyperscaling violation black holes (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-06-12
    Description: Author(s): Moisés Bravo-Gaete, Sebastián Gómez, and Mokhtar Hassaïne The aim of this paper is to propose a generalized Cardy formula for three-dimensional hyperscaling violation black holes. We first note that for the hyperscaling violation metrics, the scaling of the entropy in terms of the temperature (defined as the effective spatial dimensionality divided by the ... [Phys. Rev. D 91, 124038] Published Thu Jun 11, 2015
    Keywords: General Relativity and Gravitation
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    Theory of lasing action in plasmonic crystals (2015)
    American Physical Society (APS)
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    Publication Date: 2015-01-27
    Description: Author(s): J. Cuerda, F. Rüting, F. J. García-Vidal, and J. Bravo-Abad In the context of plasmonic nanolasers, it has been previously recognized that systems with physically extended modes (as opposed to isolated cavity modes) can support lasing, and plasmonic crystals are a platform for such effects. In the present paper the authors present a general study that explores, from a unified perspective, the lasing properties of plasmonic crystals incorporating optically pumped four-level gain media. [Phys. Rev. B 91, 041118] Published Mon Jan 26, 2015
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 3
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    Cardy formula for charged black holes with anisotropic scaling (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-12-03
    Description: Author(s): Moisés Bravo-Gaete, Sebastián Gómez, and Mokhtar Hassaïne We first observe that for Lifshitz black holes of which the only charge is the mass, the resulting Smarr relation is a direct consequence of the Lifshitz Cardy formula. From this observation, we propose to extend the Cardy formula to the case of electrically charged Lifshitz black holes satisfying a… [Phys. Rev. D 92, 124002] Published Tue Dec 01, 2015
    Keywords: General Relativity and Gravitation
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    Lifshitz black holes with a time-dependent scalar field in a Horndeski theory (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-05-17
    Description: Author(s): Moisés Bravo Gaete and Mokhtar Hassaine In arbitrary dimensions, we consider a particular Horndeski action given by the Einstein-Hilbert Lagrangian with a cosmological constant term, while the source part is described by a real scalar field with its usual kinetic term together with a nonminimal kinetic coupling. In order to evade the no-h... [Phys. Rev. D 89, 104028] Published Fri May 16, 2014
    Keywords: General Relativity and Gravitation
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 5
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    Thermodynamics of a BTZ black hole solution with a Horndeski source (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-07-02
    Description: Author(s): Moises Bravo-Gaete and Mokhtar Hassaine In three dimensions, we consider a particular truncation of the Horndeski action that reduces to the Einstein-Hilbert Lagrangian with a cosmological constant Λ and a scalar field whose dynamics is governed by its usual kinetic term together with a nonminimal kinetic coupling. Requiring the radial co... [Phys. Rev. D 90, 024008] Published Tue Jul 01, 2014
    Keywords: General Relativity and Gravitation
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 6
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    Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-07-03
    Description: Reprogramming of somatic cells is a valuable tool to understand the mechanisms of regaining pluripotency and further opens up the possibility of generating patient-specific pluripotent stem cells. Reprogramming of mouse and human somatic cells into pluripotent stem cells, designated as induced pluripotent stem (iPS) cells, has been possible with the expression of the transcription factor quartet Oct4 (also known as Pou5f1), Sox2, c-Myc and Klf4 (refs 1-11). Considering that ectopic expression of c-Myc causes tumorigenicity in offspring and that retroviruses themselves can cause insertional mutagenesis, the generation of iPS cells with a minimal number of factors may hasten the clinical application of this approach. Here we show that adult mouse neural stem cells express higher endogenous levels of Sox2 and c-Myc than embryonic stem cells, and that exogenous Oct4 together with either Klf4 or c-Myc is sufficient to generate iPS cells from neural stem cells. These two-factor iPS cells are similar to embryonic stem cells at the molecular level, contribute to development of the germ line, and form chimaeras. We propose that, in inducing pluripotency, the number of reprogramming factors can be reduced when using somatic cells that endogenously express appropriate levels of complementing factors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, Jeong Beom -- Zaehres, Holm -- Wu, Guangming -- Gentile, Luca -- Ko, Kinarm -- Sebastiano, Vittorio -- Arauzo-Bravo, Marcos J -- Ruau, David -- Han, Dong Wook -- Zenke, Martin -- Scholer, Hans R -- England -- Nature. 2008 Jul 31;454(7204):646-50. doi: 10.1038/nature07061. Epub 2008 Jun 29.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Rontgenstrasse 20, 48149 Munster, NRW, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18594515" target="_blank"〉PubMed〈/a〉
    Keywords: Adult Stem Cells/*cytology/metabolism ; Animals ; Cell Differentiation/genetics ; Cells, Cultured ; *Cellular Reprogramming ; Chimera ; DNA-Binding Proteins/genetics/metabolism ; Female ; Gene Expression Profiling ; Genes, myc/genetics ; HMGB Proteins/genetics/metabolism ; Homeodomain Proteins/genetics ; Kruppel-Like Transcription Factors/genetics/metabolism ; Male ; Mice ; Mice, Nude ; Mice, Transgenic ; Neurons/*cytology ; Octamer Transcription Factor-3/genetics/metabolism ; Pluripotent Stem Cells/*cytology/*metabolism ; Proteins/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; RNA, Untranslated ; SOXB1 Transcription Factors ; Transcription Factors/genetics/metabolism ; Transduction, Genetic
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 7
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    Direct reprogramming of human neural stem cells by OCT4 (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-09-01
    Description: Induced pluripotent stem (iPS) cells have been generated from mouse and human somatic cells by ectopic expression of four transcription factors (OCT4 (also called POU5F1), SOX2, c-Myc and KLF4). We previously reported that Oct4 alone is sufficient to reprogram directly adult mouse neural stem cells to iPS cells. Here we report the generation of one-factor human iPS cells from human fetal neural stem cells (one-factor (1F) human NiPS cells) by ectopic expression of OCT4 alone. One-factor human NiPS cells resemble human embryonic stem cells in global gene expression profiles, epigenetic status, as well as pluripotency in vitro and in vivo. These findings demonstrate that the transcription factor OCT4 is sufficient to reprogram human neural stem cells to pluripotency. One-factor iPS cell generation will advance the field further towards understanding reprogramming and generating patient-specific pluripotent stem cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, Jeong Beom -- Greber, Boris -- Arauzo-Bravo, Marcos J -- Meyer, Johann -- Park, Kook In -- Zaehres, Holm -- Scholer, Hans R -- England -- Nature. 2009 Oct 1;461(7264):649-3. doi: 10.1038/nature08436.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology, Rontgenstrasse 20, 48149 Munster, NRW, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19718018" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomarkers/analysis ; *Cell Dedifferentiation ; Cell Differentiation ; Cell Line ; *Cellular Reprogramming ; DNA Methylation ; Embryonic Stem Cells/cytology/metabolism ; Epigenesis, Genetic ; Fetus/*cytology ; Gene Expression Profiling ; Germ Layers/cytology/metabolism ; Humans ; Mice ; Neurons/*cytology/metabolism ; Octamer Transcription Factor-3/genetics/*metabolism ; Pluripotent Stem Cells/*cytology/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
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    Engineering modified Bt toxins to counter insect resistance (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-11-03
    Description: The evolution of insect resistance threatens the effectiveness of Bacillus thuringiensis (Bt) toxins that are widely used in sprays and transgenic crops. Resistance to Bt toxins in some insects is linked with mutations that disrupt a toxin-binding cadherin protein. We show that susceptibility to the Bt toxin Cry1Ab was reduced by cadherin gene silencing with RNA interference in Manduca sexta, confirming cadherin's role in Bt toxicity. Native Cry1A toxins required cadherin to form oligomers, but modified Cry1A toxins lacking one alpha-helix did not. The modified toxins killed cadherin-silenced M. sexta and Bt-resistant Pectinophora gossypiella that had cadherin deletion mutations. Our findings suggest that cadherin promotes Bt toxicity by facilitating toxin oligomerization and demonstrate that the modified Bt toxins may be useful against pests resistant to standard Bt toxins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soberon, Mario -- Pardo-Lopez, Liliana -- Lopez, Idalia -- Gomez, Isabel -- Tabashnik, Bruce E -- Bravo, Alejandra -- 1R01 AI066014/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2007 Dec 7;318(5856):1640-2. Epub 2007 Nov 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Apartado Postal 510-3, Cuernavaca 62250, Morelos, Mexico. mario@ibt.unam.mx〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17975031" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacterial Proteins/chemistry/*genetics/metabolism/*toxicity ; Bacterial Toxins/chemistry/*genetics/metabolism/*toxicity ; Cadherins/genetics/metabolism ; Endotoxins/chemistry/*genetics/metabolism/*toxicity ; Genetic Engineering ; Hemolysin Proteins/chemistry/*genetics/metabolism/*toxicity ; *Insecticide Resistance ; Larva ; *Manduca/genetics/metabolism ; *Moths/genetics/metabolism ; Mutation ; *Pest Control, Biological ; RNA Interference
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    An update of Wallace's zoogeographic regions of the world (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-12-22
    Description: Modern attempts to produce biogeographic maps focus on the distribution of species, and the maps are typically drawn without phylogenetic considerations. Here, we generate a global map of zoogeographic regions by combining data on the distributions and phylogenetic relationships of 21,037 species of amphibians, birds, and mammals. We identify 20 distinct zoogeographic regions, which are grouped into 11 larger realms. We document the lack of support for several regions previously defined based on distributional data and show that spatial turnover in the phylogenetic composition of vertebrate assemblages is higher in the Southern than in the Northern Hemisphere. We further show that the integration of phylogenetic information provides valuable insight on historical relationships among regions, permitting the identification of evolutionarily unique regions of the world.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holt, Ben G -- Lessard, Jean-Philippe -- Borregaard, Michael K -- Fritz, Susanne A -- Araujo, Miguel B -- Dimitrov, Dimitar -- Fabre, Pierre-Henri -- Graham, Catherine H -- Graves, Gary R -- Jonsson, Knud A -- Nogues-Bravo, David -- Wang, Zhiheng -- Whittaker, Robert J -- Fjeldsa, Jon -- Rahbek, Carsten -- New York, N.Y. -- Science. 2013 Jan 4;339(6115):74-8. doi: 10.1126/science.1228282. Epub 2012 Dec 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Macroecology, Evolution, and Climate, Department of Biology, University of Copenhagen, 2100 Copenhagen O, Denmark.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23258408" target="_blank"〉PubMed〈/a〉
    Keywords: Amphibians/classification ; Animals ; Birds/classification ; *Climate ; Mammals/classification ; *Phylogeny ; Phylogeography
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Control of Drosophila endocycles by E2F and CRL4(CDT2) (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-11-01
    Description: Endocycles are variant cell cycles comprised of DNA synthesis (S)- and gap (G)-phases but lacking mitosis. Such cycles facilitate post-mitotic growth in many invertebrate and plant cells, and are so ubiquitous that they may account for up to half the world's biomass. DNA replication in endocycling Drosophila cells is triggered by cyclin E/cyclin dependent kinase 2 (CYCE/CDK2), but this kinase must be inactivated during each G-phase to allow the assembly of pre-Replication Complexes (preRCs) for the next S-phase. How CYCE/CDK2 is periodically silenced to allow re-replication has not been established. Here, using genetic tests in parallel with computational modelling, we show that the endocycles of Drosophila are driven by a molecular oscillator in which the E2F1 transcription factor promotes CycE expression and S-phase initiation, S-phase then activates the CRL4(CDT2) ubiquitin ligase, and this in turn mediates the destruction of E2F1 (ref. 7). We propose that it is the transient loss of E2F1 during S phases that creates the window of low Cdk activity required for preRC formation. In support of this model overexpressed E2F1 accelerated endocycling, whereas a stabilized variant of E2F1 blocked endocycling by deregulating target genes, including CycE, as well as Cdk1 and mitotic cyclins. Moreover, we find that altering cell growth by changing nutrition or target of rapamycin (TOR) signalling impacts E2F1 translation, thereby making endocycle progression growth-dependent. Many of the regulatory interactions essential to this novel cell cycle oscillator are conserved in animals and plants, indicating that elements of this mechanism act in most growth-dependent cell cycles.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330263/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330263/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zielke, Norman -- Kim, Kerry J -- Tran, Vuong -- Shibutani, Shusaku T -- Bravo, Maria-Jose -- Nagarajan, Sabarish -- van Straaten, Monique -- Woods, Brigitte -- von Dassow, George -- Rottig, Carmen -- Lehner, Christian F -- Grewal, Savraj S -- Duronio, Robert J -- Edgar, Bruce A -- 5 P50GM66050/GM/NIGMS NIH HHS/ -- GM51186/GM/NIGMS NIH HHS/ -- GM57859/GM/NIGMS NIH HHS/ -- MOP-86622/Canadian Institutes of Health Research/Canada -- R01 GM051186/GM/NIGMS NIH HHS/ -- R01 GM051186-14A1/GM/NIGMS NIH HHS/ -- England -- Nature. 2011 Oct 30;480(7375):123-7. doi: 10.1038/nature10579.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉German Cancer Research Center (DKFZ)-Zentrum fur Molekulare Biologie der Universitat Heidelberg Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22037307" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Cycle/*physiology ; Drosophila Proteins/*metabolism ; Drosophila melanogaster/*cytology/*enzymology/growth & development/metabolism ; E2F Transcription Factors/*metabolism ; Female ; Male ; S Phase/physiology ; Salivary Glands/cytology ; Ubiquitin-Protein Ligases/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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