ISSN:
1434-193X
Keywords:
Enzymes
;
Kinetic resolution
;
Sulfoxides
;
Chiral resolution
;
Hydrolyses
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Selected racemic trans-2-alkoxycarbonyl-3,6-dihydro-2H-thiopyran S-oxides 2a-h have been subjected to enzyme-assisted hydrolysis under conditions of kinetic resolution to give the corresponding acids and recovered esters with moderate to high enantiomeric purities (up to 95%). The enantioselectivity of the reaction was found to be strongly dependent on the structures of the substrates used.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
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