ISSN:
1432-0983
Keywords:
DNA translocations
;
Electrophoretic karyotype
;
Candida albicans
;
Gene mapping
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Rotating-gel electrophoresis and DNA hybridization were used to compare the electrophoretic karyotype of six Candida albicans isolates. The hybridization pattern for 22 cloned sequences, including eight previously unmapped genes, indicates that there are eight pair of homologous chromosomes in each strain. However, since homologous chromosomes can differ in length, it is possible to resolve more than eight bands in some strains. The mapping data demonstrate that linkage groups are generally conserved suggesting that, in spite of gross karyotype differences, there is an underlying similarity in the genome organization of different isolates. The hybridization data also provide direct evidence that DNA translocations and reciprocal translocations contribute to chromosome length polymorphisms in C. albicans.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00351467
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