Publication Date:
2008-02-16
Description:
Bacterial infection often results in the formation of tissue abscesses, which represent the primary site of interaction between invading bacteria and the innate immune system. We identify the host protein calprotectin as a neutrophil-dependent factor expressed inside Staphylococcus aureus abscesses. Neutrophil-derived calprotectin inhibited S. aureus growth through chelation of nutrient Mn2+ and Zn2+: an activity that results in reprogramming of the bacterial transcriptome. The abscesses of mice lacking calprotectin were enriched in metal, and staphylococcal proliferation was enhanced in these metal-rich abscesses. These results demonstrate that calprotectin is a critical factor in the innate immune response to infection and define metal chelation as a strategy for inhibiting microbial growth inside abscessed tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Corbin, Brian D -- Seeley, Erin H -- Raab, Andrea -- Feldmann, Joerg -- Miller, Michael R -- Torres, Victor J -- Anderson, Kelsi L -- Dattilo, Brian M -- Dunman, Paul M -- Gerads, Russell -- Caprioli, Richard M -- Nacken, Wolfgang -- Chazin, Walter J -- Skaar, Eric P -- 5R01 GM58008-09/GM/NIGMS NIH HHS/ -- F32 AI071487/AI/NIAID NIH HHS/ -- P50 CA068485/CA/NCI NIH HHS/ -- R01 GM62112/GM/NIGMS NIH HHS/ -- T32 GM008320/GM/NIGMS NIH HHS/ -- T32 GM08320/GM/NIGMS NIH HHS/ -- T32 HL069765/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2008 Feb 15;319(5865):962-5. doi: 10.1126/science.1152449.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18276893" target="_blank"〉PubMed〈/a〉
Keywords:
Abscess/immunology/metabolism/*microbiology
;
Animals
;
Calcium/metabolism
;
Chelating Agents/*metabolism/pharmacology
;
Dimerization
;
Gene Expression Profiling
;
Kidney Diseases/immunology/metabolism/microbiology
;
Leukocyte L1 Antigen Complex/genetics/*metabolism/pharmacology
;
Liver Abscess/metabolism/microbiology/pathology
;
Manganese/*metabolism
;
Mass Spectrometry
;
Mice
;
Neutrophils/*metabolism
;
Staphylococcal Infections/immunology/metabolism/*microbiology
;
Staphylococcus aureus/drug effects/genetics/*growth & development
;
Zinc/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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