Publication Date:
2012-06-08
Description:
The human-microbial ecosystem plays a variety of important roles in human health and disease. Each person can be viewed as an island-like "patch" of habitat occupied by microbial assemblages formed by the fundamental processes of community ecology: dispersal, local diversification, environmental selection, and ecological drift. Community assembly theory, and metacommunity theory in particular, provides a framework for understanding the ecological dynamics of the human microbiome, such as compositional variability within and between hosts. We explore three core scenarios of human microbiome assembly: development in infants, representing assembly in previously unoccupied habitats; recovery from antibiotics, representing assembly after disturbance; and invasion by pathogens, representing assembly in the context of invasive species. Judicious application of ecological theory may lead to improved strategies for restoring and maintaining the microbiota and the crucial health-associated ecosystem services that it provides.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208626/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208626/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Costello, Elizabeth K -- Stagaman, Keaton -- Dethlefsen, Les -- Bohannan, Brendan J M -- Relman, David A -- DP1 OD000964/OD/NIH HHS/ -- DP1OD000964/OD/NIH HHS/ -- R01 GM095385/GM/NIGMS NIH HHS/ -- R01 OD011116/OD/NIH HHS/ -- R01GM095385/GM/NIGMS NIH HHS/ -- T32 GM007413/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2012 Jun 8;336(6086):1255-62. doi: 10.1126/science.1224203. Epub 2012 Jun 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22674335" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Anti-Bacterial Agents/pharmacology/*therapeutic use
;
Bacterial Infections/*microbiology
;
Biodiversity
;
Ecology
;
*Ecosystem
;
Gastrointestinal Tract/*microbiology
;
*Host-Pathogen Interactions
;
Humans
;
Infant, Newborn
;
*Metagenome
;
Selection, Genetic
;
Symbiosis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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