Publication Date:
2010-05-15
Description:
Lombardi et al. (Reports, 23 October 2009, p. 585) reported an association between the human gammaretrovirus XMRV and chronic fatigue syndrome. However, their results may be misleading because of various potential sources of bias and confounding. If real, the association may lack generalizability because of the specific characteristics of the cases studied and could be due to reverse causality.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sudlow, Cathie -- Macleod, Malcolm -- Al-Shahi Salman, Rustam -- Stone, Jon -- G108/613/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2010 May 14;328(5980):825; author reply 825. doi: 10.1126/science.1183545.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK. cathie.sudlow@ed.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20466906" target="_blank"〉PubMed〈/a〉
Keywords:
Bias (Epidemiology)
;
Blood Cells/*virology
;
Case-Control Studies
;
Confounding Factors (Epidemiology)
;
Epidemiologic Research Design
;
Fatigue Syndrome, Chronic/epidemiology/immunology/*virology
;
Gammaretrovirus/*isolation & purification
;
Humans
;
Retroviridae Infections/*virology
;
Specimen Handling
;
Tumor Virus Infections/*virology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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