ISSN:
1432-1041
Keywords:
Key words Genetic polymorphism
;
CYP2D6
;
GSTM1
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Objective: The aim of the present study was to investigate the distribution of the CYP2D6 and GSTM1 genotypes in a Polish population. Methods: One hundred and forty-five unrelated healthy individuals from the western region of Poland were studied. The CYP2D6 genotype was analysed by means of polymerase chain reaction (PCR) amplification for the CYP2D6 * 3 and CYP2D6 * 4 alleles. The GSTM1 genotype was also analysed by means of a PCR assay to determine two genotypes: GSTM1-1 (positive) and GSTM1-0 (negative). Results: Fourteen subjects (9.6%) were classified as poor metabolisers. The frequency of CYP2D6 * 4 and CYP2D6 * 3 was 23.1% and 2.1%, respectively. The frequency of GSTM1 nulled genotype in a Polish population came to 49%. Conclusion: The frequencies of poor metabolisers for CYP2D6 and GSTM1 nulled genotype among a Polish population were similar to those observed in other Caucasian populations.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002280050645
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