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  • GEOPHYSICS  (6)
  • pharmacokinetics  (3)
  • 1985-1989  (9)
  • 1930-1934
  • 1
    Electronic Resource
    Electronic Resource
    The effect of cimetidine on the pharmacokinetics, pharmacodynamics and alpha1-adrenoceptor responsiveness of trimazosin in man (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 301-306 
    Details
    ISSN: 1432-1041
    Keywords: trimazosin ; cimetidine ; pharmacokinetics ; alpha-adrenoceptor antagonism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of cimetidine treatment on the pharmacokinetics and pharmacodynamics of single doses of trimazosin was studied in 6 normotensive volunteers. Co-administration of cimetidine did not significantly affect the overall magnitude of the hypotensive effect of trimazosin. However, the time profile of the blood pressure response was significantly modified particularly with attenuation of the delayed component. Co-administration of cimetidine did not alter alpha1-adrenoceptor antagonism by trimazosin. There was no significant change in the clearnace and volume of distribution of trimazosin but there was a significant reduction in the area under the concentration-time curve for the metabolite, 1-hydroxytrimazosin. The reduction in the AUC of 1-hydroxy-trimazosin corresponds in time with the attenuation of the delayed hypotensive response. This is consistent with the suggestion that the delayed hypotensive response is related to an active metabolite, probably 1-hydroxytrimazosin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544084
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The pharmacokinetics of low-dose dexamethasone in congenital adrenal hyperplasia (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 75-77 
    Details
    ISSN: 1432-1041
    Keywords: dexamethasone ; congenital adrenal hyperplasia ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of dexamethasone, given at low dose, were studied in 13 patients with congenital adrenal hyperplasia (CAH) to ascertain whether kinetics differed in this inherited disorder of cortisol metabolism from those seen in healthy individuals. Changes in plasma dexamethasone concentration after intravenous bolus, measured using a simple novel radioimmunoassay, were well described by a two-compartment open model with first-order kinetics. Values for λ2: 0.206 h−1, t1/2: 3.53 h, Vc: 24.41 and f: 0.64 were similar to those previously reported for normal subjects. There were considerable interindividual differences in parameter values and Cmaxp.o. (range 22–67 nmol/l). As suppression of the hypothalamo-pituitary-adrenal axis correlates with plasma dexamethasone levels, this variability may partly explain the differing dose and dose schedule requirements necessary to achieve adequate therapeutic control in the clinical management of CAH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609429
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Antisecretory effect and oral pharmacokinetics of omeprazole in patients with chronic renal failure (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 637-640 
    Details
    ISSN: 1432-1041
    Keywords: omeprazole ; renal failure ; gastric secretion ; pharmacokinetics ; haemodialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The inhibitory effect of omeprazole on gastric acid secretion was tested in a group of patients on haemodialysis for chronic renal failure. Single 30 mg doses almost totally inhibited basal acid output on both dialysis and non-dialysis days. Plateau acid output was reduced by a mean of 77% and 90% on non-dialysis and dialysis days respectively. The absorption and pharmacokinetic profile of omeprazole were not affected by dialysis. Omeprazole was not recoverable from dialysis fluid. It is concluded that omeprazole is a potent inhibitor of gastric acid secretion in patients with chronic renal failure, and its effect is not influenced by haemodialysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607907
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  • 4
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    Enhancements of energetic ions associated with travelling compression regions in the deep geomagnetic tail (1987)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: This paper presents a representative example of an enhancement in energetic ion flux associated with the International Sun-Earth Explorer 3 (ISEE 3) spacecraft's encounter with a traveling compression region (TCR). Data from the energetic particle anisotropy spectrometer (EPAS) instrument on ISEE 3 are studied, along with magnetic field data from the vector helium magnetometer. It is concluded that the ion enhancements seen are spatial in nature, thus supporting the idea that TCRs are the lobe signatures of plasmoids moving along the magnetotail, away from earth.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 92; 64-70
    Format: text
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  • 5
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    CDAW 8 observations of plasmoid signatures in the geomagnetic tail - An assessment (1989)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: Magnetotail observations from the ISEE 3 distant (1983) tail mission taken during the Coordinated Data Analysis Workshop 8 (CDAW 8) A and G events are investigated. The ISEE 3 magnetic field, plasma, and energetic particle measurements taken in these two plasmoids have been analyzed and compared with various equilibrium structures and propagating waves/tail oscillation modes. Results indicate general agreement with either the closed-loop (Hones, 1977) or very small pitch angle flux rope (Hughes and Sibeck, 1987; Birn et al., 1989) models of plasmoid structure and poorer agreement with other hypotheses. Calculations based upon typical plasmoid and tail parameters are presented, indicating that the J and B force associated with the disconnected lobe field lines may be sufficient to accelerate plasmoids up to the speeds observed by ISEE 3. Overall, the energy expended in accelerating the plasmoids down the tail appears comparable to that dissipated in the inner magnetosphere and ionosphere. The study produces strong evidence in favor of the plasmoid model of substorm tail dynamics.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 94; 15153-15
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  • 6
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    On the 3-dimensional structure of plasmoids (1987)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: The hypothesis that the IMF penetrates plasmoids causing them to be three- rather than two-dimensional is tested by comparing observations of By within plasmoids and related tail structures to upstream IMF By data. The magnetic topologies that result from the mergings of closed plasma sheet flux tubes and open tail lobe flux tubes at a near-earth neutral line, and merging near the tail flanks are described and studied. The particle signals and isotropic electron distributions are examined. It is observed that the IMF By penetrates plasmoids and that their structure is three-dimensional. In the three-dimensional model of plasmoids the reconnected plasma sheet field lines form a magnetic flux-ropelike structure. The three-dimensional model is utilized to analyze stagnant, slowly moving and earthward moving structures.
    Keywords: GEOPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 14; 636-639
    Format: text
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  • 7
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    Magnetic disturbances in the vicinity of synchronous orbit and the substorm current wedge - A case study (1985)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: It is pointed out that magnetospheric substorms have been referred to as the 'fundamental instability' of the magnetosphere which results from coupling between the solar wind and the earth's magnetic and plasma environment. The present paper is mainly concerned with magnetic observations made by the midlatitude Air Force Geophysics Laboratory (AFGL) Magnetometer Network, the GOES 2 and 3 synchronous satellites, and the near-geosynchronous P78-2 Spacecraft Charging at High Altitudes (SCATHA) satellite. Ground-based Pi 2 and magnetic bay observations are used to detect a clear substorm onset. An idealized model of the substorm current system is utilized to relate the observations to the spatial location and temporal development of the substorm disturbance near synchronous orbit.
    Keywords: GEOPHYSICS
    Type: AD-A161938 , AFGL-TR-85-0284 , Journal of Geophysical Research (ISSN 0148-0227); 90; 9583-958
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  • 8
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    Observations of field-aligned currents, waves, and electric fields at substorm onset (1986)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: Substorm onsets, identified Pi 2 pulsations observed on the Air Force Geophysics Laboratory Magnetometer Network, are studied using magnetometer and electric field data from ISEE 1 as well as magnetometer data from the geosynchronous satellites GOES 2 and 3. The mid-latitude magnetometer data provides the means of both timing and locating the substorm onset so that the spacecraft locations with respect to the substorm current systems are known. During two intervals, each containing several onsets or intensifications, ISEE 1 observed field-aligned current signatures beginning simultaneously with the mid-latitude Pi 2 pulsation. Close to the earth broadband bursts of wave noise were observed in the electric field data whenever field-aligned currents were detected. One onset occurred when ISEE 1 and GOES 2 were on the same field line but in opposite hemispheres. During this onset ISEE 1 and GOES 2 saw magnetic signatures which appear to be due to conjugate field-aligned currents flowing out of the western end of the westward auroral electrojets. The ISEE 1 signature is of a line current moving westward past the spacecraft. During the other interval, ISEE 1 was in the near-tail region near the midnight meridian. Plasma data confirms that the plasma sheet thinned and subsequently expanded at onset. Electric field data shows that the plasma moved in the opposite direction to the plasma sheet boundary as the boundary expanded which implies that there must have been an abundant source of hot plasma present. The plasma motion was towards the center of the plasma sheet and earthwards and consisted of a series of pulses rather than a steady flow.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 91; 121-134
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  • 9
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    Dispersive ducting of MHD waves in the plasma sheet - A source of Pi2 wave bursts (1986)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: Fast magnetoacoustic waves can be ducted by plasma inhomogeneities such as the plasma sheet. As this ducting is dispersive an impulsive source will give rise to a well-defined, quasi-periodic wave packet with time-scales determined by the width of the inhomogeneity and characteristic speeds in the wave duct and surrounding medium. The duration of the wave packet depends upon the distance from the source. It is argued that an impulsive source in the plasma sheet at substorm onset will produce a wave packet near earth with characteristics similar to pi2 wave bursts and put this idea forward as a mechanism for the generation of pi2 pulsations.
    Keywords: GEOPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 13; 373-376
    Format: text
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