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Gamma-aminobutyric acid uptake by rat kidney brush-border membrane vesicles (1989)

Sidhu, H. S. ; Wood, J. D.

Springer

Cellular and molecular life sciences 45 (1989), S. 726-728

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ISSN: 1420-9071

Keywords: GABA ; transport ; kidney ; brush-border membrane vesicles

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Brush-border membrane vesicles (BBMV) from rat kidney cortex possessed two uptake systems for γ-aminobutyric acid (GABA), a high affinity system (Km=10.9 μM) and a low affinity system (Km=1203 μM). Both uptake systems were inhibited by p-hydroxymercuribenzoic acid and ouabain, and by the action of neuraminidase, whereas the GABA analogs nipecotic acid, β-alanine, 2,4-diaminobutyric acid and 4,5,6,7-tetrahydroisoxazolo-[4,5c]-pyridin-3-ol had no effect on the GABA uptake activity. The BBMW uptake systems were clearly different from the GABA transport systems present in brain tissue.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01974569

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